BACKGROUND:<\/p>\n
Plaquepsoriasiscan occur in all body regions, with the trunk and extremities among the most commonly affected areas. A fixed combination halobetasol propionate 0.01%\/tazarotene 0.045% (HP\/TAZ) lotion demonstrated efficacy and safety in patients with moderate-to-severe localized plaquepsoriasis. This analysis evaluated patients where a psoriatic target lesion was identified on the leg.<\/p>\n
In two phase 3, multicenter, double-blind studies, participants were randomized (2:1) to receive HP\/TAZ or vehicle lotion once-daily for 8 weeks. This pooled, post hoc analysis included a subset of participants who had a leg target lesion (HP\/TAZ, n=148; vehicle, n=71). Efficacy assessments included treatment success (2-grade improvement) inpsoriasissigns (erythema, plaque elevation, scaling) on the leg target lesion, and overall treatment outcomes, including overall treatment success (2-grade improvement in Investigators Global Assessment [IGA] score and score of clear\/almost clear), affected Body Surface Area (BSA), and IGAxBSA composite score.<\/p>\n
Psoriasissigns were reduced by week 8, with more HP\/TAZ treated participants achieving treatment success for erythema (41.6%), plaque elevation (58.5%), and scaling (59.5%) on the leg compared with vehicle (12.5%, 19.2%, and 21.0%, respectively; P<0.001 all). Significantly more participants achieved overall treatment success at week 8 with HP\/TAZ versus vehicle (36.4% vs 10.4%; P<0.001). The HP\/TAZ group also had a greater mean reduction in affected BSA and IGAxBSA score versus vehicle (P<0.001, both). The most frequently reported treatment-related adverse event (incidence, 3%) with HP\/TAZ was contact dermatitis.<\/p>\n
HP 0.01%\/TAZ 0.045% lotion was associated with significant reductions in disease severity and good tolerability following 8 weeks of treatment in patients where a psoriatic target lesion was identified on the leg. J Drugs Dermatol. 2020;19(4):389-396. doi:10.36849\/JDD.2020.4958.<\/p>\n
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See the article here: BACKGROUND: Plaquepsoriasiscan occur in all body regions, with the trunk and extremities among the most commonly affected areas. A fixed combination halobetasol propionate 0.01%\/tazarotene 0.045% (HP\/TAZ) lotion demonstrated efficacy and safety in patients with moderate-to-severe localized plaquepsoriasis. This analysis evaluated patients where a psoriatic target lesion was identified on the leg. Continue reading
\nHalobetasol Propionate 0.01%\/Tazarotene 0.045% Lotion for Moderate-to-Severe Psoriasis: Pooled Phase 3 Analysis of Lower Extremities - DocWire News<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"