PUBLIC RELEASE DATE: <\/p>\n
8-Jan-2014 <\/p>\n
Contact: Nan Broadbent nbroadbe@sfsu.edu<\/a> 415-338-7108 San Francisco State University<\/p>\n SAN FRANCISCO -- A team of researchers including SF State Assistant Professor of Biology Scott Roy has sequenced the entire genome of the elephant shark, uncovering several features that may shed light on the evolution of bony vertebrates. <\/p>\n The study is the first whole-genome analysis of a cartilaginous fish. Cartilaginous fishes include sharks, rays and skates. Together with bony fish, birds, reptiles, amphibians and mammals, they make up the branch of jawed vertebrates on life's family tree. <\/p>\n The elephant shark genome is relatively small, consisting of slightly fewer than a billion DNA base pairs compared with 3 billion base pairs in humans. But this spare sequence has yielded some intriguing details, the researchers write. For instance, the elephant shark lacks the genes for secreted phosphoproteins, which may explain why their cartilage is not converted into bone as in the other jawed vertebrates. <\/p>\n They also lack the genes for several key immune system cells and protein receptors in the adaptive immune system, which provides carefully targeted defenses against specific disease threats. This finding, say the researchers, may suggest that the adaptive immune system in jawed vertebrates gradually became more elaborate over time. <\/p>\n One of the most notable features of the elephant shark's genome is its incredibly slow rate of evolution, said Roy. Even slower than in \"living fossils\" such as the coelacanth, the elephant shark's genome has not changed substantially in hundreds of millions of years. <\/p>\n This slow rate of evolution was uncovered in part by Roy's analysis of the genome's introns. Introns are the part of the genetic sequence that \"interrupts\" genes, and must be spliced out before the gene can be expressed. In vertebrates, these introns can be thousands of DNA letters long and must include their own splicing instructions. <\/p>\n There have been very few intron changes in the elephant shark genome, but this isn't entirely surprising, noted Roy, who has studied intron organization across a variety of organisms, including humans. \"It's pretty well established in vertebrates that very little of this intron loss and creation occurs.\" <\/p>\n <\/p>\n Read the original here: PUBLIC RELEASE DATE: 8-Jan-2014 Contact: Nan Broadbent nbroadbe@sfsu.edu<\/a> 415-338-7108 San Francisco State University SAN FRANCISCO -- A team of researchers including SF State Assistant Professor of Biology Scott Roy has sequenced the entire genome of the elephant shark, uncovering several features that may shed light on the evolution of bony vertebrates. The study is the first whole-genome analysis of a cartilaginous fish. Cartilaginous fishes include sharks, rays and skates. Continue reading
\nSlow-evolving elephant shark genome is first to be sequenced from cartilaginous fish<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"