PUBLIC RELEASE DATE: <\/p>\n
7-Jan-2014 <\/p>\n
Contact: Maria Jenmalm, Professor maria.jenmalm@liu.se<\/a> 46-702-378-970 Linkping University<\/p>\n Low gut microbial diversity in the intestines of infants can increase the risk for asthma development. These are the findings of the age 7 follow-up in a multi-year study led by researchers at Linkping University. <\/p>\n In 2011 the results of a comprehensive survey of the intestinal microbiota of allergic and healthy children were published. In the samples from the infancy period, the degree of variation and diversity of the bacteria strains was significantly lower among those who had developed allergic eczema when they were two years old. <\/p>\n A follow-up study was conducted when the 47 participating infants reached their seventh birthday. By then eight of them 17% were suffering from chronic asthma. 28% had hay fever, 26% still had eczema, and 34% reacted to the allergens in a skin prick test. But it was only the asthma cases that could be connected to low intestinal microbial diversity at the age of one week and one month, according to the results now being published in the scientific journal Clinical & Experimental Allergy. <\/p>\n It might seem a bit of a stretch to think the contents of the intestines could influence what happens in the airways. The results of this study, however, give further credence to this connection, which has previously been demonstrated in animal studies. <\/p>\n \"A high diversity of gut microbiota during the first months of life seems to be important for the maturation of the immune system,\" says Thomas Abrahamsson, paediatrician and researcher at Linkping University, and principal author of the article. The hypothesis is that in order to function effectively, the immune system needs to be \"trained\" by large numbers of different microorganisms. In the absence of sufficient stimulation from large numbers of different bacteria, the system may overreact to innocuous antigens it encounters. <\/p>\n A high gut microbial diversity has also been shown to strengthen the barrier function of the mucous membrane. <\/p>\n \"We are speculating that a deficient maturity of the immune system at an earlier age and a less efficient mucosa barrier function can open the way to certain types of viral infection that can be linked to the development of asthma,\" says senior author Maria Jenmalm, professor of experimental allergology. <\/p>\n <\/p>\n More: PUBLIC RELEASE DATE: 7-Jan-2014 Contact: Maria Jenmalm, Professor maria.jenmalm@liu.se<\/a> 46-702-378-970 Linkping University Low gut microbial diversity in the intestines of infants can increase the risk for asthma development. Continue reading
\nLow diversity of bacteria may increase the risk for asthma<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"