In Brief A study by a team from the Houston Methodist Research Institute showed the potential of a treatment that targets telomeres in chromosomes to reverse cellular aging. Lab tests using cells from patients with genetic disease causing accelerated aging proved to be promising. The Mechanisms of Aging <\/p>\n
For a phenomenon that affects all living beings, theres nothing simple about aging. Experimentsthat focus on understanding aging are as numerous and varied as the aspects of the subject itself. Some look at the roles that the brain or the mitochondria have on aging, while others examine some protein or another. A study from the Houston Methodist Research Institute(HMRI) is focusing on chromosomes. <\/p>\n
Specifically, the team led by cardiovascular sciences department chair John Cooke, looked at telomeres the region located at the tip of every chromosome, thelength of which supposedly corresponds to age. Cookes team studied the cells of children with a fatalgenetic disease called progeria that causes rapid aging. <\/p>\n
In their study, published in the Journal of the American College of Cardiology, the researchers discovered that extending the shortened telomeres effectively halted aging in the isolated sample cells taken from the patients with progeria. What weve shown is that when we reverse the process of the telomere shortening in the cells from these children and lengthen them, it can reverse a lot of the problems associated with aging, Cooke said in an HMRI press release. <\/p>\n
Cookes team isnt the first to associate telomeres with aging. The field, however, isnt considered that precise yet. Medical genetics professor Peter Lansdorp at the University of British Columbia told Motherboardthat theres still a lot to learn in this area. It is not hard to find a 70-year-old with longer telomeres than a teenager, he said, noting that the decline in telomeres works as a tumor suppression mechanism for the body. <\/p>\n
Furthermore, since the study was limited to cell samples taken from just 17 patients on a lab dish, the researchers still need to see if it could work in cells functioning inside the body. The next step is to deliver the same treatment directly into patients, beginning with children suffering from progeria. <\/p>\n
Still, Cooke is hopeful. We can at least stall or slow down accelerated aging, and thats what were working toward, he said in the press release. I want to develop a therapy for these children. Its an unmet need. <\/p>\n
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\nNew Research Suggests We Can Stop Human Cells From Aging - Futurism<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"