Recently, a DNA test appeared with a premise so far-fetched that its fate was profane and merciless ridicule. Soccer Genomics offers personalized, DNA-based training regimens to young players, and its goofy ad went viral amid internet outrage. It is, alas, only the most recent example of the growing field of sometimes-dubious lifestyle DNA tests. <\/p>\n
Its a jungle out there, says Eric Topol, a genomicist at the Scripps Research Institute. As DNA sequencing has gotten cheaper, a number of small companies have looked to fill niches around the two big consumer DNA-testing behemoths, 23andMe and AncestryDNA. These newer tests usually dont offer disease-risk information, which would bring the scrutiny of the FDA, but they skirt the boundaries by focusing on nutrition and fitness. Sometimes, they just aim for fun, like a DNA test for wine preferences. Ive likened these lifestyle tests to horoscopesvague, occasionally informative, sometimes amusing. <\/p>\n
The DNA Test as Horoscope <\/p>\n
Into this jungle now comes a new player with an impressive pedigree. Helix is a new venture from private equity firms and Illumina, the company that makes most of the DNA-sequencing machines in the United States. 23andMe and AncestryDNA use Illuminas machines, as do most research labs. On Monday, after two years of anticipation since the initial announcement, Helix officially launched a marketplace for products based on DNA tests. <\/p>\n
Helix has an innovative business model. Most DNA-testing companies only look for a set number of variants in DNA. Helix sequences all of the expressed genes in the bodya technique called whole-exome sequencing. This is very expensive, but Helix subsidizes most of the cost aside from one-time $80 sequencing fee. Then, it has third-party developers create products focused on specific genetic information. The products available now include everything from a National Geographic ancestry test, to personalized diet coaching, to a custom DNA-based scarf. You pay for each individual product, and the prices range from under $100 to a couple hundred. <\/p>\n
The companys CEO, Robin Thurston, likens Helix to the Apple app store, which is a very deliberate comparison. Unlike Google, which takes a fairly hands-off approach to apps in the Google Play store, Apple individually reviews every app. Helix has a 14-person team that reviews the science behind each of the products they feature, too, which is how the company plans to differentiate itself from the world of pseudoscientific DNA tests. Hopefully it will translate into us telling consumers that being on the Helix platform is different, says Thurston. You can trust Helix in the long run. (Just to be clear, Soccer Genomics has nothing to do with Helix.) <\/p>\n
Oleksandr Savsunenko, the CEO of Titanovo, whose DNA Diet Coach product was slated to be sold on the Helix platform, gave me a rundown of Helixs scientific review process. He says his company had originally submitted 200 scientific studies to back up the recommendations in their product60 to 70 percent of which did not meet Helixs standards. That includes a 68-person study that an earlier version of Titanovos product used to recommend cloudy apple juice for fat loss. Of course I was disappointed when they started to say this is bad, this is bad, this is bad, but in the end the product we have obtained is really strong, says Savsunenko. Titanovo is now discontinuing the earlier product, called DNA Lifestyle Coach, to focus exclusively on its DNA Diet Coach product through Helix. <\/p>\n
(Sometime after the interview with Savsunenko, a Helix spokesperson said DNA Diet Coach would no longer be included in Mondays marketplace launch: Titanovos beta testing identified some areas that need fine-tuning before broad release and hence decided to hold off launching on Monday.) <\/p>\n
Products currently available through Helix have gotten criticism though, especially a DNA test for wine preference, made by a company called Vinome. The gist of the skepticism goes like this: DNA can tell you what a person can taste, but it cant really tell you if that person will like it. Thurston says he thinks Vinome meets their scientific standard because the company makes clear that their taste algorithm is based on more than DNA. Vinome also uses an questionnaire, and sure, that can get at your personal taste preferences. <\/p>\n
At that point, though, how much value is the DNA test itself adding? Even when there is solid evidence linking a gene to a predisposition, the relationship is probabilistic. Its more like you are 30 percent more likely to grow blue hair than you will definitely grow blue hair. Genes and the environment interact to affect health outcomes. At least some of the products on Helixs platform seem to resolve this ambiguity by basing advice on things that have nothing to do with DNA. <\/p>\n
Another partner, EverlyWell, sells a number of tests for proteins and fats in the blood and breast milk. It is now selling through Helix a plus version of its food-sensitivity, metabolism, and breast-milk tests that also looks at DNA. If you already have the blood test that reveals what your body is doing now, whats the additional value of the DNA test that reveals what your body could potentially be doing? <\/p>\n
My perspective is that genetic data is valuable to give you a baseline, says EverlyWells CEO, Julia Cheek. She points out that someone who has low magnesium levels might want to know they have a predisposition to low magnesium so they can adjust their diet. Alternatively, one or two low magnesium tests might prompt the same diet adjustments. <\/p>\n
On one hand, this strategy of integrating DNA tests with other sources of information allows Helixs partners to hew closer to the established science of genetics. On the other, DNA sequencing is obviously the real draw of Helixs marketplace, and whole exome sequencing is orders of magnitude more expensive than a questionnaire or blood test. <\/p>\n
Topol, who follows genomic medicine closely, is skeptical that current direct-to-consumer DNA tests have much utility for healthy people. Helix was created to help Illumina sell more DNA-sequencing machines by growing the space for consumer tests. And if these new tests dont actually demonstrate the value of DNA sequencing, Topol says it could lead to backlash. It could lead to a lesser opinion of genomics, he says. Im afraid of that as well. <\/p>\n
Since Helix was announced in 2015 to fanfare and a $100 million investment, its unusual business model has been the subject of much speculation. Now its marketplace is finally here, and you can decide for yourself. <\/p>\n
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\nHow Do You Know When a DNA Test Is BS? - The Atlantic<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"