{"id":1119323,"date":"2023-11-15T03:03:01","date_gmt":"2023-11-15T08:03:01","guid":{"rendered":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/uncategorized\/clinically-relevant-antibiotic-resistance-genes-are-linked-to-a-limited-nature-com\/"},"modified":"2023-11-15T03:03:01","modified_gmt":"2023-11-15T08:03:01","slug":"clinically-relevant-antibiotic-resistance-genes-are-linked-to-a-limited-nature-com","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/transhuman-news-blog\/human-genetics\/clinically-relevant-antibiotic-resistance-genes-are-linked-to-a-limited-nature-com\/","title":{"rendered":"Clinically relevant antibiotic resistance genes are linked to a limited &#8230; &#8211; Nature.com"},"content":{"rendered":"<p><p>        Murray, C. J. et al. Global burden of bacterial        antimicrobial resistance in 2019: a systematic analysis.        Lancet 399, 629655 (2022).      <\/p>\n<p>        Article        CAS         Google Scholar      <\/p>\n<p>        Brito, I. L. et al. Mobile genes in the human microbiome        are structured from global to individual scales.        Nature 535, 435439 (2016).      <\/p>\n<p>        Article ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Pehrsson, E. C. et al. Interconnected microbiomes and        resistomes in low-income human habitats. Nature        533, 212216 (2016).      <\/p>\n<p>        Article ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Zhang, Z. et al. Assessment of global health risk of        antibiotic resistance genes. Nat. Commun. 13,        1553 (2022).      <\/p>\n<p>        Article        ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Zhou, H., Beltrn, J. F. & Brito, I. L. Functions predict        horizontal gene transfer and the emergence of antibiotic        resistance. Sci. Adv. 7, eabj5056 (2021).      <\/p>\n<p>        Article ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Smillie, C. S. et al. Ecology drives a global network of        gene exchange connecting the human microbiome.        Nature 480, 241244 (2011).      <\/p>\n<p>        Article ADS CAS PubMed                Google Scholar      <\/p>\n<p>        Maier, L. et al. Unravelling the collateral damage of        antibiotics on gut bacteria. Nature 599,        120124 (2021).      <\/p>\n<p>        Article        ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Lamberte, L. E. & van Schaik, W. Antibiotic resistance in        the commensal human gut microbiota. Curr. Opin.        Microbiol. 68, 102150 (2022).      <\/p>\n<p>        Article        CAS PubMed                Google Scholar      <\/p>\n<p>        Ghosh, T. S., Gupta, S. S., Nair, G. B. & Mande, S. S. In        silico analysis of antibiotic resistance genes in the gut        microflora of individuals from diverse geographies and        age-groups. PLoS ONE 8, e83823 (2013).      <\/p>\n<p>        Article        ADS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Rahman, S. F., Olm, M. R., Morowitz, M. J. & Banfield, J.        F. Machine learning leveraging genomes from metagenomes        identifies influential antibiotic resistance genes in the        infant gut microbiome. mSystems 3, e0012317        (2018).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Gibson, M. K. et al. Developmental dynamics of the preterm        infant gut microbiota and antibiotic resistome. Nat.        Microbiol. 1, 110 (2016).      <\/p>\n<p>        Article                Google Scholar      <\/p>\n<p>        Hu, Y. et al. Metagenome-wide analysis of antibiotic        resistance genes in a large cohort of human gut microbiota.        Nat. Commun. 4, 2151 (2013).      <\/p>\n<p>        Article ADS PubMed                Google Scholar      <\/p>\n<p>        Yassour, M. et al. Natural history of the infant gut        microbiome and impact of antibiotic treatment on bacterial        strain diversity and stability. Sci. Transl. Med.        8, 343ra81343ra81 (2016).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Forster, S. C. et al. Strain-level characterization of        broad host range mobile genetic elements transferring        antibiotic resistance from the human microbiome. Nat.        Commun. 13, 1445 (2022).      <\/p>\n<p>        Article        ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Jiang, X. et al. Dissemination of antibiotic resistance        genes from antibiotic producers to pathogens. Nat.        Commun. 8, 15784 (2017).      <\/p>\n<p>        Article ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Ronda, C., Chen, S. P., Cabral, V., Yaung, S. J. & Wang, H.        H. Metagenomic engineering of the mammalian gut microbiome        in situ. Nat. Methods 16, 167170 (2019).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Munck, C., Sheth, R. U., Freedberg, D. E. & Wang, H. H.        Recording mobile DNA in the gut microbiota using an        Escherichia coli CRISPR-Cas spacer acquisition platform.        Nat. Commun. 11, 95 (2020).      <\/p>\n<p>        Article        ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Sawa, T., Kooguchi, K. & Moriyama, K. Molecular diversity        of extended-spectrum -lactamases and carbapenemases, and        antimicrobial resistance. J. Intensive Care        8, 13 (2020).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Pasolli E, Schiffer L, Manghi P, Renson A, Obenchain V,        Truong DT, Beghini F, Malik F, Ramos M, Dowd JB,        Huttenhower C, Morgan M, Segata N, Waldron L. Accessible,        curated metagenomic data through ExperimentHub. Nat        Methods. 14, 10231024 (2017).      <\/p>\n<p>        Alcock, B. P. et al. CARD 2023: expanded curation, support        for machine learning, and resistome prediction at the        Comprehensive Antibiotic Resistance Database. Nucleic        Acids Res. 51, D690D699 (2023).      <\/p>\n<p>        Article CAS PubMed                Google Scholar      <\/p>\n<p>        WHO model list of essential medicines  22nd list.         <a href=\"https:\/\/www.who.int\/publications-detail-redirect\/WHO-MHP-HPS-EML-2021.02\" rel=\"nofollow\">https:\/\/www.who.int\/publications-detail-redirect\/WHO-MHP-HPS-EML-2021.02<\/a>        (2021)      <\/p>\n<p>        Du, D. et al. Multidrug efflux pumps: structure, function        and regulation. Nat. Rev. Microbiol. 16,        523539 (2018).      <\/p>\n<p>        Article        CAS PubMed                Google Scholar      <\/p>\n<p>        Nielsen, T. K., Browne, P. D. & Hansen, L. H. Antibiotic        resistance genes are differentially mobilized according to        resistance mechanism. GigaScience 11, giac072        (2022).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Lopatkin, A. J. et al. Clinically relevant mutations in        core metabolic genes confer antibiotic resistance.        Science 371, eaba0862 (2021).      <\/p>\n<p>        Article CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Pasolli, E. et al. Accessible, curated metagenomic data        through ExperimentHub. Nat. Methods 14,        10231024 (2017).      <\/p>\n<p>        Article CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Hendriksen, R. S. et al. Global monitoring of antimicrobial        resistance based on metagenomics analyses of urban sewage.        Nat. Commun. 10, 1124 (2019).      <\/p>\n<p>        Article        ADS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Munk, P. et al. Genomic analysis of sewage from 101        countries reveals global landscape of antimicrobial        resistance. Nat. Commun. 13, 7251 (2022).      <\/p>\n<p>        Article        ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Maugeri, A., Barchitta, M., Puglisi, F. & Agodi, A.        Socio-economic, governance and health indicators shaping        antimicrobial resistance: an ecological analysis of 30        european countries. Glob. Health 19, 12        (2023).      <\/p>\n<p>        Article                Google Scholar      <\/p>\n<p>        Collignon, P., Beggs, J. J., Walsh, T. R., Gandra, S. &        Laxminarayan, R. Anthropological and socioeconomic factors        contributing to global antimicrobial resistance: a        univariate and multivariable analysis. Lancet Planet.        Health 2, e398e405 (2018).      <\/p>\n<p>        Article        PubMed                Google Scholar      <\/p>\n<p>        Zhang, Z. et al. Genetic diversity and characteristics of        blaNDM-positive plasmids in Escherichia coli.        Front. Microbiol. 12, 729952 (2021).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Philippon, A., Arlet, G. & Jacoby, G. A. Plasmid-determined        AmpC-type -lactamases. Antimicrob. Agents        Chemother. 46, 111 (2002).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Wexler, A. G. & Goodman, A. L. An insiders perspective:        bacteroides as a window into the microbiome. Nat.        Microbiol. 2, 111 (2017).      <\/p>\n<p>        Article                Google Scholar      <\/p>\n<p>        Montassier, E. et al. Probiotics impact the antibiotic        resistance gene reservoir along the human GI tract in a        person-specific and antibiotic-dependent manner. Nat.        Microbiol. 6, 10431054 (2021).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Anthony, W. E. et al. Acute and persistent effects of        commonly used antibiotics on the gut microbiome and        resistome in healthy adults. Cell Rep. 39,        110649 (2022).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        WHO report on surveillance of antibiotic consumption.                <a href=\"https:\/\/www.who.int\/publications-detail-redirect\/who-report-on-surveillance-of-antibiotic-consumption\" rel=\"nofollow\">https:\/\/www.who.int\/publications-detail-redirect\/who-report-on-surveillance-of-antibiotic-consumption<\/a>.      <\/p>\n<p>        Feng, Y. et al. Rapid detection of new delhi        metallo--lactamase gene using recombinase-aided        amplification directly on clinical samples from children.        Front. Microbiol. 12, 691289 (2021).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Day, K. M. et al. Prevalence and molecular characterization        of Enterobacteriaceae producing NDM-1 carbapenemase at a        military hospital in Pakistan and evaluation of two        chromogenic media. Diagn. Microbiol. Infect. Dis.        75, 187191 (2013).      <\/p>\n<p>        Article        CAS PubMed                Google Scholar      <\/p>\n<p>        Yong, D. et al. Characterization of a new        metallo-beta-lactamase gene, bla(NDM-1), and a novel        erythromycin esterase gene carried on a unique genetic        structure in Klebsiella pneumoniae sequence type 14 from        India. Antimicrob. Agents Chemother. 53,        50465054 (2009).      <\/p>\n<p>        Article CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Moquet, O. et al. Class D OXA-48 Carbapenemase in        Multidrug-Resistant Enterobacteria, Senegal. Emerg.        Infect. Dis. 17, 143144 (2011).      <\/p>\n<p>        Article PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Evans, B. A. & Amyes, S. G. B. OXA -Lactamases. Clin.        Microbiol. Rev. 27, 241263 (2014).      <\/p>\n<p>        Article PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Zaheer, R. et al. Comparative diversity of microbiomes and        resistomes in beef feedlots, downstream environments and        urban sewage influent. BMC Microbiol. 19, 197        (2019).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Zaheer, R. et al. Impact of sequencing depth on the        characterization of the microbiome and resistome. Sci.        Rep. 8, 5890 (2018).      <\/p>\n<p>        Article        ADS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Yokoyama, M. et al. Microbial diversity and antimicrobial        resistance in faecal samples from acute medical patients        assessed through metagenomic sequencing. PLoS ONE        18, e0282584 (2023).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Yan, J. et al. A compilation of fecal microbiome shotgun        metagenomics from hematopoietic cell transplantation        patients. Sci. Data 9, 219 (2022).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Xiao, L. et al. A reference gene catalogue of the pig gut        microbiome. Nat. Microbiol. 1, 16 (2016).      <\/p>\n<p>        Article                Google Scholar      <\/p>\n<p>        Wu, D. et al. Inhalable antibiotic resistomes emitted from        hospitals: metagenomic insights into bacterial hosts,        clinical relevance, and environmental risks.        Microbiome 10, 19 (2022).      <\/p>\n<p>        Article        CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Talat, A., Blake, K. S., Dantas, G. & Khan, A. U.        Metagenomic insight into microbiome and antibiotic        resistance genes of high clinical concern in urban and        rural hospital wastewater of northern India origin: a major        reservoir of antimicrobial resistance. Microbiol.        Spectr. 11, e04102e04122 (2023).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Takahashi, E. et al. Metagenomic analysis of diarrheal        stools in Kolkata, India, indicates the possibility of        subclinical infection of Vibrio cholerae O1. Sci.        Rep. 12, 19473 (2022).      <\/p>\n<p>        Article        ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Schneider, D., Amann, N., Wicke, D., Poehlein, A. &        Daniel, R. Metagenomes of wastewater at different treatment        stages in central Germany. Microbiol. Resour.        Announc. 9, e00201e00220 (2020).      <\/p>\n<p>        Article PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Majeed, H. J. et al. Evaluation of metagenomic-enabled        antibiotic resistance surveillance at a conventional        wastewater treatment plant. Front. Microbiol.        12, 657954 (2021).      <\/p>\n<p>        Article        PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        Lira, F., Vaz-Moreira, I., Tamames, J., Manaia, C. M. &        Martnez, J. L. Metagenomic analysis of an urban resistome        before and after wastewater treatment. Sci. Rep.        10, 8174 (2020).      <\/p>\n<p>        Article        ADS CAS PubMed        PubMed        Central         Google Scholar      <\/p>\n<p>        King, P. et al. Longitudinal metagenomic analysis of        hospital air identifies clinically relevant microbes.        PLoS ONE 11, e0160124 (2016).      <\/p>\n<p><!-- Auto Generated --><\/p>\n<p>Read more here:<br \/>\n<a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41467-023-42998-6\" title=\"Clinically relevant antibiotic resistance genes are linked to a limited ... - Nature.com\" rel=\"noopener\">Clinically relevant antibiotic resistance genes are linked to a limited ... - Nature.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p> Murray, C. J. et al <a href=\"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/transhuman-news-blog\/human-genetics\/clinically-relevant-antibiotic-resistance-genes-are-linked-to-a-limited-nature-com\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[],"class_list":["post-1119323","post","type-post","status-publish","format-standard","hentry","category-human-genetics"],"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts\/1119323"}],"collection":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/comments?post=1119323"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts\/1119323\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/media?parent=1119323"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/categories?post=1119323"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/tags?post=1119323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}