King, M. C. & Wilson, A. C. Evolution at two levels in humans and chimpanzees. Science 188, 107116 (1975). <\/p>\n
Article ADS CAS PubMed Google Scholar <\/p>\n
Konopka, G. et al. Human-specific transcriptional networks in the brain. Neuron 75, 601617 (2012). <\/p>\n
Article CAS PubMed PubMed Central Google Scholar <\/p>\n
Liu, X. et al. Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. 22, 611622 (2012). <\/p>\n
Article CAS PubMed PubMed Central Google Scholar <\/p>\n
Sousa, A. M. M. et al. Molecular and cellular reorganization of neural circuits in the human lineage. Science 358, 10271032 (2017). <\/p>\n
Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n
Zhu, Y. et al. Spatiotemporal transcriptomic divergence across human and macaque brain development. Science https:\/\/doi.org\/10.1126\/science.aat8077<\/a> (2018). <\/p>\n Hodge, R. D. et al. Conserved cell types with divergent features in human versus mouse cortex. Nature 573, 6168 (2019). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Bakken, T. E. et al. Comparative cellular analysis of motor cortex in human, marmoset and mouse. Nature 598, 111119 (2021). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Miller, D. J. et al. Prolonged myelination in human neocortical evolution. Proc. Natl Acad. Sci. USA 109, 1648016485 (2012). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Jakel, S. et al. Altered human oligodendrocyte heterogeneity in multiple sclerosis. Nature 566, 543547 (2019). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Jeong, H. et al. Evolution of DNA methylation in the human brain. Nat. Commun. 12, 2021 (2021). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Khrameeva, E. et al. Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains. Genome Res. 30, 776789 (2020). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Kozlenkov, A. et al. Evolution of regulatory signatures in primate cortical neurons at cell-type resolution. Proc. Natl Acad. Sci. USA 117, 2842228432 (2020). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Krienen, F. M. et al. Innovations present in the primate interneuron repertoire. Nature 586, 262269 (2020). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Ma, S. et al. Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science https:\/\/doi.org\/10.1126\/science.abo7257<\/a> (2022). <\/p>\n Mendizabal, I. et al. Comparative methylome analyses identify epigenetic regulatory loci of human brain evolution. Mol. Biol. Evol. 33, 29472959 (2016). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Li, W., Mai, X. & Liu, C. The default mode network and social understanding of others: what do brain connectivity studies tell us. Front. Hum. Neurosci. 8, 74 (2014). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Wang, D. et al. Altered functional connectivity of the cingulate subregions in schizophrenia. Transl. Psychiatry 5, e575 (2015). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Berto, S. et al. Accelerated evolution of oligodendrocytes in the human brain. Proc. Natl Acad. Sci. USA 116, 2433424342 (2019). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Franjic, D. et al. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Neuron 110, 452469 (2022). <\/p>\n Article CAS PubMed Google Scholar <\/p>\n Brown, T. L. & Verden, D. R. Cytoskeletal regulation of oligodendrocyte differentiation and myelination. J. Neurosci. 37, 77977799 (2017). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Caglayan, E., Liu, Y. & Konopka, G. Neuronal ambient RNA contamination causes misinterpreted and masked cell types in brain single-nuclei datasets. Neuron https:\/\/doi.org\/10.1016\/j.neuron.2022.09.010<\/a> (2022). <\/p>\n Lake, B. B. et al. Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain. Nat. Biotechnol. 36, 7080 (2018). <\/p>\n Article CAS PubMed Google Scholar <\/p>\n Velmeshev, D. et al. Single-cell genomics identifies cell type-specific molecular changes in autism. Science 364, 685689 (2019). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Fumagalli, M. et al. The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization. Glia 63, 23272339 (2015). <\/p>\n Article PubMed Google Scholar <\/p>\n den Hoed, J., Devaraju, K. & Fisher, S. E. Molecular networks of the FOXP2 transcription factor in the brain. EMBO Rep. 22, e52803 (2021). <\/p>\n Article Google Scholar <\/p>\n Konopka, G. et al. Human-specific transcriptional regulation of CNS development genes by FOXP2. Nature 462, 213217 (2009). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Doan, R. N. et al. Mutations in human accelerated regions disrupt cognition and social behavior. Cell 167, 341354 (2016). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Franchini, L. F. & Pollard, K. S. Human evolution: the non-coding revolution. BMC Biol. 15, 89 (2017). <\/p>\n Article PubMed PubMed Central Google Scholar <\/p>\n Capra, J. A., Erwin, G. D., McKinsey, G., Rubenstein, J. L. & Pollard, K. S. Many human accelerated regions are developmental enhancers. Philos. Trans. R. Soc. Lond. B 368, 20130025 (2013). <\/p>\n Article Google Scholar <\/p>\n Girskis, K. M. et al. Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions. Neuron https:\/\/doi.org\/10.1016\/j.neuron.2021.08.005<\/a> (2021). <\/p>\n Wagnon, J. L. et al. CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function. PLoS Genet. 8, e1003067 (2012). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Lundgaard, I. et al. Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes. PLoS Biol. 11, e1001743 (2013). <\/p>\n Article PubMed PubMed Central Google Scholar <\/p>\n Prufer, K. et al. The complete genome sequence of a Neanderthal from the Altai Mountains. Nature 505, 4349 (2014). <\/p>\n Article ADS PubMed Google Scholar <\/p>\n Arora, V. et al. Increased Grik4 gene dosage causes imbalanced circuit output and human disease-related behaviors. Cell Rep. 23, 38273838 (2018). <\/p>\n Article CAS PubMed Google Scholar <\/p>\n Kim, T. K. et al. Widespread transcription at neuronal activity-regulated enhancers. Nature 465, 182187 (2010). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Yap, E. L. & Greenberg, M. E. Activity-regulated transcription: bridging the gap between neural activity and behavior. Neuron 100, 330348 (2018). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Berto, S. et al. Gene-expression correlates of the oscillatory signatures supporting human episodic memory encoding. Nat. Neurosci. 24, 554564 (2021). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Ducker, G. S. & Rabinowitz, J. D. One-carbon metabolism in health and disease. Cell Metab. 25, 2742 (2017). <\/p>\n Article CAS PubMed Google Scholar <\/p>\n Yeung, M. S. et al. Dynamics of oligodendrocyte generation and myelination in the human brain. Cell 159, 766774 (2014). <\/p>\n Article CAS PubMed Google Scholar <\/p>\n Marques, S. et al. Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system. Science 352, 13261329 (2016). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Buchanan, J. et al. Oligodendrocyte precursor cells ingest axons in the mouse neocortex. Proc. Natl Acad. Sci. USA 119, e2202580119 (2022). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Jorstad, N. L. et al. Comparative transcriptomics reveals human-specific cortical features. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2022.09.19.508480<\/a> (2022). <\/p>\n Berg, M. et al. FastCAR: Fast Correction for Ambient RNA to facilitate differential gene expression analysis in single-cell RNA-sequencing datasets. Preprint at bioRxiv https:\/\/doi.org\/10.1101\/2022.07.19.500594<\/a> (2022). <\/p>\n McLean, C. Y. et al. Human-specific loss of regulatory DNA and the evolution of human-specific traits. Nature 471, 216219 (2011). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Hickey, S. L., Berto, S. & Konopka, G. Chromatin decondensation by FOXP2 promotes human neuron maturation and expression of neurodevelopmental disease genes. Cell Rep. 27, 16991711 (2019). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Yang, C. C. et al. Discovering chromatin motifs using FAIRE sequencing and the human diploid genome. BMC Genomics 14, 310 (2013). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Ataman, B. et al. Evolution of osteocrin as an activity-regulated factor in the primate brain. Nature 539, 242247 (2016). <\/p>\n Article ADS PubMed PubMed Central Google Scholar <\/p>\n Pruunsild, P., Bengtson, C. P. & Bading, H. Networks of cultured iPSC-derived neurons reveal the human synaptic activity-regulated adaptive gene program. Cell Rep. 18, 122135 (2017). <\/p>\n Article CAS PubMed PubMed Central Google Scholar <\/p>\n Qiu, J. et al. Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons. Elife https:\/\/doi.org\/10.7554\/eLife.20337<\/a> (2016). <\/p>\n Hrvatin, S. et al. Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat. Neurosci. 21, 120129 (2018). <\/p>\n Article CAS PubMed Google Scholar <\/p>\n Zheng, G. X. et al. Massively parallel digital transcriptional profiling of single cells. Nat. Commun. 8, 14049 (2017). <\/p>\n Article ADS CAS PubMed PubMed Central Google Scholar <\/p>\n Li, H. et al. The Sequence Alignment\/Map format and SAMtools. Bioinformatics 25, 20782079 (2009). <\/p>\n Article PubMed PubMed Central Google Scholar <\/p>\n Zhao, H. et al. CrossMap: a versatile tool for coordinate conversion between genome assemblies. Bioinformatics 30, 10061007 (2014). <\/p>\n Article PubMed Google Scholar <\/p>\n Liao, Y., Smyth, G. K. & Shi, W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30, 923930 (2014). <\/p>\n <\/p>\n Read the original: <\/p>\n Molecular features driving cellular complexity of human brain evolution - Nature.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" King, M. C. & Wilson, A. Continue reading