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Pontzer, H., Wood, B. M. & Raichlen, D. A. Hunter-gatherers as models in public health. Obes. Rev. 19, 2435 (2018).<\/p>\n

PubMed Article Google Scholar <\/p>\n

Sonnenburg, J. L. & Sonnenburg, E. D. Vulnerability of the industrialized microbiota. Science 366, eaaw9255 (2019).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Kenyon, C. J. The genetics of ageing. Nature 464, 504512 (2010).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Lpez-Otn, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 11941217 (2013).<\/p>\n

PubMed PubMed Central Article CAS Google Scholar <\/p>\n

Wilson, K. A. et al. Evaluating the beneficial effects of dietary restrictions: a framework for precision nutrigeroscience. Cell Metab. 33, 21422173 (2021).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Rodgers, G. P. & Collins, F. S. Precision nutrition-the answer to what to eat to stay healthy. JAMA 324, 735736 (2020).<\/p>\n

PubMed Article Google Scholar <\/p>\n

Liu, G. Y. & Sabatini, D. M. mTOR at the nexus of nutrition, growth, ageing and disease. Nat. Rev. Mol. Cell Biol. 21, 183203 (2020).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Szwed, A., Kim, E. & Jacinto, E. Regulation and metabolic functions of mTORC1 and mTORC2. Physiol. Rev. 101, 13711426 (2021).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Harrison, D. E. et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392395 (2009).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Dorling, J. L., Martin, C. K. & Redman, L. M. Calorie restriction for enhanced longevity: the role of novel dietary strategies in the present obesogenic environment. Ageing Res. Rev. 64, 101038 (2020).<\/p>\n

PubMed PubMed Central Article Google Scholar <\/p>\n

Sowah, S. A. et al. Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial. Genome Med. 14, 30 (2022).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

O'Flanagan, C. H., Smith, L. A., McDonell, S. B. & Hursting, S. D. When less may be more: calorie restriction and response to cancer therapy. BMC Med. 15, 106 (2017).<\/p>\n

PubMed PubMed Central Article CAS Google Scholar <\/p>\n

Madeo, F., Carmona-Gutierrez, D., Hofer, S. J. & Kroemer, G. Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential. Cell Metab. 29, 592610 (2019).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Chong, C. R., Sallustio, B. & Horowitz, J. D. Drugs that affect cardiac metabolism: focus on perhexiline. Cardiovasc Drugs Ther. 30, 399405 (2016).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Schreiber, K. H. et al. A novel rapamycin analog is highly selective for mTORC1 in vivo. Nat. Commun. 10, 3194 (2019).<\/p>\n

PubMed PubMed Central Article CAS Google Scholar <\/p>\n

Lamming, D. W. et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335, 16381643 (2012).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Sarbassov, D. D. et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt\/PKB. Mol. Cell 22, 159168 (2006).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Gonzlez, A., Hall, M. N., Lin, S. C. & Hardie, D. G. AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control. Cell Metab. 31, 472492 (2020).<\/p>\n

PubMed Article CAS Google Scholar <\/p>\n

Lin, S. C. & Hardie, D. G. AMPK: sensing glucose as well as cellular energy status. Cell Metab. 27, 299313 (2018).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Fontana, L. & Partridge, L. Promoting health and longevity through diet: from model organisms to humans. Cell 161, 106118 (2015).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Kapahi, P., Kaeberlein, M. & Hansen, M. Dietary restriction and lifespan: lessons from invertebrate models. Ageing Res. Rev. 39, 314 (2017).<\/p>\n

PubMed Article Google Scholar <\/p>\n

Schulz, T. J. et al. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 6, 280293 (2007).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Ristow, M. & Zarse, K. How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis). Exp. Gerontol. 45, 410418 (2010).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Weir, H. J. et al. Dietary restriction and AMPK increase lifespan via mitochondrial network and peroxisome remodeling. Cell Metab. 26, 884896.e5 (2017).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Boccardi, V., Murasecco, I. & Mecocci, P. Diabetes drugs in the fight against Alzheimer's disease. Ageing Res. Rev. 54, 100936 (2019).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Calissi, G., Lam, E. W. & Link, W. Therapeutic strategies targeting FOXO transcription factors. Nat. Rev. Drug Disco. 20, 2138 (2021).<\/p>\n

CAS Article Google Scholar <\/p>\n

Greer, E. L. & Brunet, A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8, 113127 (2009).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Giannakou, M. E., Goss, M. & Partridge, L. Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell 7, 187198 (2008).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Miyauchi, T. et al. Up-regulation of FOXO1 and reduced inflammation by -hydroxybutyric acid are essential diet restriction benefits against liver injury. Proc. Natl Acad. Sci. USA 116, 1353313542 (2019).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Furuyama, T. et al. Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles. Microsc. Res. Tech. 59, 331334 (2002).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Shimokawa, I. et al. The life-extending effect of dietary restriction requires Foxo3 in mice. Aging Cell 14, 707709 (2015).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Xia, Y. et al. Neuronal C\/EBP\/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression. Sci. Adv. 8, eabj8658 (2022).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Zhu, S. et al. The roles of sirtuins family in cell metabolism during tumor development. Semin. Cancer Biol. 57, 5971 (2019).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Xie, N. et al. NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct. Target Ther. 5, 227 (2020).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Covarrubias, A. J., Perrone, R., Grozio, A. & Verdin, E. NAD(+) metabolism and its roles in cellular processes during ageing. Nat. Rev. Mol. Cell Biol. 22, 119141 (2021).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Lin, S. J., Defossez, P. A. & Guarente, L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 21262128 (2000).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Houtkooper, R. H., Pirinen, E. & Auwerx, J. Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell Biol. 13, 225238 (2012).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Cohen, H. Y. et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305, 390392 (2004).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Han, X. et al. Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy. Pharm. Ther. 229, 107983 (2022).<\/p>\n

CAS Article Google Scholar <\/p>\n

Civitarese, A. E. et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 4, e76 (2007).<\/p>\n

PubMed PubMed Central Article CAS Google Scholar <\/p>\n

Gomes, P. et al. The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders. Ageing Res. Rev. 57, 100983 (2020).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Nakagawa, T., Lomb, D. J., Haigis, M. C. & Guarente, L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137, 560570 (2009).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Bordone, L. et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6, 759767 (2007).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Herranz, D. et al. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat. Commun. 1, 3 (2010).<\/p>\n

PubMed Article CAS Google Scholar <\/p>\n

North, B. J. et al. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 33, 14381453 (2014).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Benigni, A. et al. Sirt3 deficiency shortens life span and impairs cardiac mitochondrial function rescued by Opa1 gene transfer. Antioxid. Redox Signal 31, 12551271 (2019).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Brown, K. et al. SIRT3 reverses aging-associated degeneration. Cell Rep. 3, 319327 (2013).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Kawahara, T. L. et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 136, 6274 (2009).<\/p>\n

CAS PubMed PubMed Central Article Google Scholar <\/p>\n

Vakhrusheva, O. et al. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 102, 703710 (2008).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

Korotkov, A., Seluanov, A. & Gorbunova, V. Sirtuin 6: linking longevity with genome and epigenome stability. Trends Cell Biol. 31, 9941006 (2021).<\/p>\n

CAS PubMed Article Google Scholar <\/p>\n

<\/p>\n

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