{"id":1077573,"date":"2022-06-15T18:28:05","date_gmt":"2022-06-15T22:28:05","guid":{"rendered":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/uncategorized\/alcohol-use-disorder-is-associated-with-dna-methylation-based-shortening-of-telomere-length-and-regulated-by-tespa1-implications-for-aging\/"},"modified":"2022-06-15T18:28:05","modified_gmt":"2022-06-15T22:28:05","slug":"alcohol-use-disorder-is-associated-with-dna-methylation-based-shortening-of-telomere-length-and-regulated-by-tespa1-implications-for-aging","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/transhuman-news-blog\/dna\/alcohol-use-disorder-is-associated-with-dna-methylation-based-shortening-of-telomere-length-and-regulated-by-tespa1-implications-for-aging\/","title":{"rendered":"Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging |&#8230;"},"content":{"rendered":"<p><p>Griswold MG, Fullman N, Hawley C, Arian N, Zimsen SRM, Tymeson HD, et al. Alcohol use and burden for 195 countries and territories, 19902016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2018;392:101535.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Udo T, Vasquez E, Shaw BA. A lifetime history of alcohol use disorder increases risk for chronic medical conditions after stable remission. Drug Alcohol Depend. 2015;157:6874.<\/p>\n<p>PubMed    Article                        Google Scholar                <\/p>\n<p>Westman J, Wahlbeck K, Laursen TM, Gissler M, Nordentoft M, Hallgren J, et al. Mortality and life expectancy of people with alcohol use disorder in Denmark, Finland and Sweden. Acta Psychiatr Scand. 2015;131:297306.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Koh SH, Choi SH, Jeong JH, Jang JW, Park KW, Kim EJ, et al. Telomere shortening reflecting physical aging is associated with cognitive decline and dementia conversion in mild cognitive impairment due to Alzheimers disease. Aging-Us. 2020;12:440723.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Lindqvist D, Epel ES, Mellon SH, Penninx BW, Revesz D, Verhoeven JE, et al. Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging. Neurosci Biobehav R. 2015;55:33364.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Ma HX, Zhou ZY, Wei S, Liu ZS, Pooley KA, Dunning AM, et al. Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis. Plos One. 2011;6:e20466.<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Nilsson PM, Tufvesson H, Leosdottir M, Melander O. Telomeres and cardiovascular disease risk: an update 2013. Transl Res. 2013;162:37180.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Rosoff DB, Charlet K, Jung J, Lee J, Muench C, Luo A, et al. Association of High-Intensity Binge Drinking With Lipid and Liver Function Enzyme Levels. JAMA Netw Open. 2019;2:e195844.<\/p>\n<p>PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Rosoff DB, Smith GD, Mehta N, Clarke TK, Lohoff FW. Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study. Plos Med. 2020;17:e1003410.<\/p>\n<p>PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Wang JQ, Liu YR, Xia QR, Xia Q, Wang BS, Yang CC, et al. Potential roles of telomeres and telomerase in neurodegenerative diseases. Int J Biol Macromol. 2020;163:106078.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Luo A, Jung J, Longley M, Rosoff DB, Charlet K, Muench C, et al. Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2. Neuropsychopharmacology. 2020;45:32736.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Rosen AD, Robertson KD, Hlady RA, Muench C, Lee J, Philibert R, et al. DNA methylation age is accelerated in alcohol dependence. Transl Psychiatry. 2018;8:182.<\/p>\n<p>PubMed    PubMed Central    Article    CAS                        Google Scholar                <\/p>\n<p>Lohoff FW. Pharmacotherapies and personalized medicine for alcohol use disorder: a review. Pharmacogenomics. 2020;21:111738.<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Wang JF, Dong X, Cao L, Sun YY, Qiu Y, Zhang Y, et al. Association between telomere length and diabetes mellitus: A meta-analysis. J Int Med Res. 2016;44:115673.<\/p>\n<p>PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Xu C, Wang ZQ, Su XQ, Da M, Yang ZC, Duan WW, et al. Association between leucocyte telomere length and cardiovascular disease in a large general population in the United States. Sci Rep. 2020;10:80.<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Zhao JZ, Miao K, Wang HR, Ding H, Wang DW. Association between Telomere Length and Type 2 Diabetes Mellitus: A Meta-Analysis. Plos One. 2013;8:e79993.<\/p>\n<p>PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Shammas MA. Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care. 2011;14:2834.<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Chen BH, Carty CL, Kimura M, Kark JD, Chen W, Li SX, et al. Leukocyte telomere length, T cell composition and DNA methylation age. Aging-Us. 2017;9:198395.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Armanios M. Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Investig. 2013;123:9961002.<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Broer L, Codd V, Nyholt DR, Deelen J, Mangino M, Willemsen G, et al. Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet. 2013;21:11638.<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Hjelmborg JB, Dalgard C, Moller S, Steenstrup T, Kimura M, Christensen K, et al. The heritability of leucocyte telomere length dynamics. J Med Genet. 2015;52:297302.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Honig LS, Kang MS, Cheng R, Eckfeldt JH, Thyagarajan B, Leiendecker-Foster C, et al. Heritability of telomere length in a study of long-lived families. Neurobiol Aging. 2015;36:278590.<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>de Carvalho LM, Wiers CE, Manza P, Sun H, Schwandt M, Wang GJ, et al. Effect of alcohol use disorder on cellular aging. Psychopharmacology. 2019;236:324555.<\/p>\n<p>Article    CAS                        Google Scholar                <\/p>\n<p>Dixit S, Whooley MA, Vittinghoff E, Roberts JD, Heckbert SR, Fitzpatrick AL, et al. Alcohol consumption and leukocyte telomere length. Sci Rep. 2019;9:1404.<\/p>\n<p>PubMed    PubMed Central    Article    CAS                        Google Scholar                <\/p>\n<p>Navarro-Mateu F, Husky M, Cayuela-Fuentes P, Alvarez FJ, Roca-Vega A, Rubio-Aparicio M, et al. The association of telomere length with substance use disorders: a systematic review and meta-analysis of observational studies. Addiction. 2021;116:195472.<\/p>\n<p>PubMed    Article                        Google Scholar                <\/p>\n<p>Strandberg TE, Strandberg AY, Saijonmaa O, Tilvis RS, Pitkala KH, Fyhrquist F. Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study. Eur J Epidemiol. 2012;27:81522.<\/p>\n<p>PubMed    Article                        Google Scholar                <\/p>\n<p>Montpetit AJ, Alhareeri AA, Montpetit M, Starkweather AR, Elmore LW, Filler K, et al. Telomere Length A Review of Methods for Measurement. Nurs Res. 2014;63:28999.<\/p>\n<p>PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Lu AT, Seeboth A, Tsai PC, Sun D, Quach A, Reiner AP, et al. DNA methylation-based estimator of telomere length. Aging (Albany NY). 2019;11:5895923.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Lohoff FW, Roy A, Jung J, Longley M, Rosoff DB, Luo A, et al. Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation. Mol Psychiatr. 2021;26:222437.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Lohoff FW, Sorcher JL, Rosen AD, Mauro KL, Fanelli RR, Momenan R, et al. Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder. Mol Psychiatry. 2018;23:111.<\/p>\n<p>Article    CAS                        Google Scholar                <\/p>\n<p>Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY). 2019;11:30327.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Lu AT, Xue L, Salfati EL, Chen BH, Ferrucci L, Levy D, et al. GWAS of epigenetic aging rates in blood reveals a critical role for TERT. Nat Commun. 2018;9:387.<\/p>\n<p>PubMed    PubMed Central    Article    CAS                        Google Scholar                <\/p>\n<p>Sobell LC, Sobell MB Timeline Follow-Back. In: Litten RZ, Allen JP, editors. Measuring Alcohol Consumption: Psychosocial and Biochemical Methods. Totowa, NJ: Humana Press; 1992, pp 4172.<\/p>\n<p>Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom KO. The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br J Addict. 1991;86:111927.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Houseman EA, Kile ML, Christiani DC, Ince TA, Kelsey KT, Marsit CJ. Reference-free deconvolution of DNA methylation data and mediation by cell composition effects. BMC Bioinforma. 2016;17:259.<\/p>\n<p>Article    CAS                        Google Scholar                <\/p>\n<p>Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14:R115.<\/p>\n<p>PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018;10:57391.<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Horvath S, Oshima J, Martin GM, Lu AT, Quach A, Cohen H, et al. Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies. Aging (Albany NY). 2018;10:175875.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49:35967.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Tippmann S. Programming Tools: Adventures with R. Nature. 2015;517:10910.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Das S, Forer L, Schonherr S, Sidore C, Locke AE, Kwong A, et al. Next-generation genotype imputation service and methods. Nat Genet. 2016;48:12847.<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Genomes Project C, Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, et al. A global reference for human genetic variation. Nature. 2015;526:6874.<\/p>\n<p>Article    CAS                        Google Scholar                <\/p>\n<p>Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38:9049.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet. 2008;40:1619.<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, et al. Towards a knowledge-based Human Protein Atlas. Nat Biotechnol. 2010;28:124850.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Trabzuni D, Ryten M, Walker R, Smith C, Imran S, Ramasamy A, et al. Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies (vol 119, pg 275, 2011). J Neurochemistry. 2012;120:473473.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Fischl B. FreeSurfer. Neuroimage. 2012;62:77481.<\/p>\n<p>PubMed    Article                        Google Scholar                <\/p>\n<p>Destrieux C, Fischl B, Dale A, Halgren E. Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature. Neuroimage. 2010;53:115.<\/p>\n<p>PubMed    Article                        Google Scholar                <\/p>\n<p>Sled JG, Zijdenbos AP, Evans AC. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. Ieee T Med Imaging. 1998;17:8797.<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Segonne F, Dale AM, Busa E, Glessner M, Salat D, Hahn HK, et al. A hybrid approach to the skull stripping problem in MRI. Neuroimage. 2004;22:106075.<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Navrady LB, Wolters MK, MacIntyre DJ, Clarke TK, Campbell AI, Murray AD, et al. Cohort Profile: Stratifying Resilience and Depression Longitudinally (STRADL): a questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS:SFHS). Int J Epidemiol. 2018;47:1314g.<\/p>\n<p><!-- Auto Generated --><\/p>\n<p>Read the original here:<br \/>\n<a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41380-022-01624-5\" title=\"Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging |...\" rel=\"noopener\">Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging |...<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p> Griswold MG, Fullman N, Hawley C, Arian N, Zimsen SRM, Tymeson HD, et al. Alcohol use and burden for 195 countries and territories, 19902016: a systematic analysis for the Global Burden of Disease Study 2016.  <a href=\"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/transhuman-news-blog\/dna\/alcohol-use-disorder-is-associated-with-dna-methylation-based-shortening-of-telomere-length-and-regulated-by-tespa1-implications-for-aging\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-1077573","post","type-post","status-publish","format-standard","hentry","category-dna"],"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts\/1077573"}],"collection":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/comments?post=1077573"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts\/1077573\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/media?parent=1077573"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/categories?post=1077573"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/tags?post=1077573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}