Sharma, A. et al. Global trends in pesticides: A looming threat and viable alternatives. Ecotoxicol. Environ. Safe 201, 110812. https:\/\/doi.org\/10.1016\/j.ecoenv.2020.110812<\/a> (2020).<\/p>\n CAS Article Google Scholar <\/p>\n Morillo, E. & Villaverde, J. Advanced technologies for the remediation of pesticide-contaminated soils. Sci. Total Environ. 586, 576597. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.02.020<\/a> (2017).<\/p>\n ADS CAS Article PubMed Google Scholar <\/p>\n Bind, V. & Kumar, A. Pesticides toxicity may causes adverse effects to our health-a review. MOJ Toxicol. 5, 1718 (2019).<\/p>\n Google Scholar <\/p>\n Giordano, G. et al. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol. Appl. Pharmacol. 219(23), 181189. https:\/\/doi.org\/10.1016\/j.taap.2006.09.016<\/a> (2007).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Wang, C. et al. Enantioselective interaction with acetylcholinesterase of an organophosphate insecticide fenamiphos. Chiral. Pharmacol. Biol. Chem. Conseq. Mole. Asym. 22(6), 612617. https:\/\/doi.org\/10.1002\/chir.20800<\/a> (2010).<\/p>\n CAS Article Google Scholar <\/p>\n European Commission implementing regulation (EU) 2020\/18. Off J Eur U 13.1.2020: L7\/14-L7\/16. http:\/\/data.europa.eu\/eli\/reg_impl\/2020\/18\/oj<\/a> (2020).<\/p>\n Lee, W. et al. Pesticide use and colorectal cancer risk in the Agricultural Health Study. Int. J. Cancer. 121(2), 339346. https:\/\/doi.org\/10.1002\/ijc.22635<\/a> (2007).<\/p>\n CAS Article PubMed PubMed Central Google Scholar <\/p>\n Alavanja, M. C. et al. A Pesticides and lung cancer risk in the agricultural health study cohort. Am. J. Epidemiol. 160(9), 876885. https:\/\/doi.org\/10.1093\/aje\/kwh290<\/a> (2004).<\/p>\n Article PubMed Google Scholar <\/p>\n Madrigal, J. M. et al. Residential exposure to carbamate, organophosphate, and pyrethroid insecticides in house dust and risk of childhood acute lymphoblastic leukemia. Environ. Res. https:\/\/doi.org\/10.1016\/j.envres.2021.111501<\/a> (2021).<\/p>\n Article PubMed Google Scholar <\/p>\n IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Some organophosphate insecticides and herbicides. PMID:31829533 (2017).<\/p>\n Guyton, K. Z. et al. International agency for research on cancer monograph working group ILF. Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. Lancet Oncol. 16(5), 490491. https:\/\/doi.org\/10.1016\/S1470-2045(15)70134-8<\/a> (2015).<\/p>\n Article PubMed Google Scholar <\/p>\n Koureas, M., Tsakalof, A., Tsatsakis, A. & Hadjichristodoulou, C. Systematic review of biomonitoring studies to determine the association between exposure to organophosphorus and pyrethroid insecticides and human health outcomes. Toxicol. Lett. 210(2), 155168. https:\/\/doi.org\/10.1016\/j.toxlet.2011.10.007<\/a> (2012).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Chen, S. et al. Exposure to pyrethroid pesticides and the risk of childhood brain tumors in East China. Environ Pollut 218, 11281134. https:\/\/doi.org\/10.1016\/j.envpol.2016.08.066<\/a> (2016).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Kannarkat, G. T. et al. Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinsons disease: An observational and casecontrol study. NPJ. Parkinsons Disease 1, 19. https:\/\/doi.org\/10.1038\/npjparkd.2015.2<\/a> (2015).<\/p>\n CAS Article Google Scholar <\/p>\n Paul, K. C. et al. Organophosphate pesticides and PON1 L55M in Parkinsons disease progression. Environ. Int. 107, 7581. https:\/\/doi.org\/10.1016\/j.envint.2017.06.018<\/a> (2017).<\/p>\n CAS Article PubMed PubMed Central Google Scholar <\/p>\n Javeres, M. N. L. et al. Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations. Environ. Res. 191, 110210. https:\/\/doi.org\/10.1016\/j.envres.2020.110210<\/a> (2020).<\/p>\n CAS Article Google Scholar <\/p>\n Li, H. L., Liu, D. P. & Liang, C. C. Paraoxonase gene polymorphisms, oxidative stress, and diseases. J. Mol. Med. 81(12), 766779. https:\/\/doi.org\/10.1007\/s00109-003-0481-4<\/a> (2003).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Czajka, M. et al. Organophosphorus pesticides can influence the development of obesity and type 2 diabetes with concomitant metabolic changes. Environ. Res. 178, 108685. https:\/\/doi.org\/10.1016\/j.envres.2019.108685<\/a> (2019).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Gutirrez-Jara, J. P., Crdova-Lepe, F. D., Muoz-Quezada, M. T. & Chowell, G. Susceptibility to organophosphates pesticides and the development of infectious-contagious respiratory diseases. J. Theor. Biol. 488, 110133. https:\/\/doi.org\/10.1016\/j.jtbi.2019.110133<\/a> (2020).<\/p>\n MathSciNet CAS Article PubMed MATH Google Scholar <\/p>\n Abreu-Villaca, Y. & Levin, E. D. Developmental neurotoxicity of succeeding generations of insecticides. Environ. Int. 99, 5577. https:\/\/doi.org\/10.1016\/j.envint.2016.11.019<\/a> (2017).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Demirel, T. et al. Association of paraoxonase (PON1) polymorphisms and activity with colorectal cancer predisposition. Biotechnol. Biotechnol. Equip. 35, 232238. https:\/\/doi.org\/10.1080\/13102818.2020.1867006<\/a> (2021).<\/p>\n CAS Article Google Scholar <\/p>\n Abolhassani, M. et al. Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study. Ecotoxicol. Environ. Saf. 178, 168177. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.04.030<\/a> (2019).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Littlefield, J. W. NIH 3T3 cell line. Science 218(4569), 214216. https:\/\/doi.org\/10.1126\/science.218.4569.214.c<\/a> (1982).<\/p>\n ADS CAS Article PubMed Google Scholar <\/p>\n Kahl, V. F. S. et al. Role of PON1, SOD2, OGG1, XRCC1, and XRCC4 polymorphisms on modulation of DNA damage in workers occupationally exposed to pesticides. Ecotox. Environ. Saf. 159, 164171. https:\/\/doi.org\/10.1016\/j.ecoenv.2018.04.052<\/a> (2018).<\/p>\n CAS Article Google Scholar <\/p>\n Medina-Daz, I. M. et al. Downregulation of human paraoxonase 1 (PON1) by organophosphate pesticides in HepG2 cells. Environ. Toxicol. 32(2), 490500. https:\/\/doi.org\/10.1002\/tox.22253<\/a> (2017).<\/p>\n ADS CAS Article PubMed Google Scholar <\/p>\n Dardiotis, E. et al. Paraoxonase-1 genetic polymorphisms in organophosphate metabolism. Toxicology 411, 2431. https:\/\/doi.org\/10.1016\/j.tox.2018.10.012<\/a> (2019).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Mackness, M. & Mackness, B. Human paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological roles. Gene 567, 1221. https:\/\/doi.org\/10.1016\/j.gene.2015.04.088<\/a> (2015).<\/p>\n CAS Article PubMed PubMed Central Google Scholar <\/p>\n Tsatsakis, A. M., Zafiropoulos, A., Tzatzarakis, M. N., Tzanakakis, G. N. & Kafatos, A. Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides. Toxicol. Lett. 186, 6672. https:\/\/doi.org\/10.1016\/j.toxlet.2008.10.018<\/a> (2009).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Costa, L. G., Cole, T. B., Vitalone, A. & Furlong, C. E. Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Clin. Chim. Acta 352(12), 3747. https:\/\/doi.org\/10.1016\/j.cccn.2004.09.019<\/a> (2005).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Kaur, G., Jain, A. K. & Kaur, S. CYP\/PON genetic variations as determinant of organophosphate pesticides toxicity. J. Genet. 96, 187201. https:\/\/doi.org\/10.1007\/s12041-017-0741-7<\/a> (2017).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Szmen, B., Peker, , Kaya, ., Erkan, M. & Szmen, E. Y. Markers of long-term exposure to organophosphorus pesticides in farmers who work in viniculture and tobacco production in Turkey. Toxicol. Mech. Methods 17(7), 379384. https:\/\/doi.org\/10.1080\/15376510601094115<\/a> (2007).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Imran, I., Saleem, S., Azhar, A. & Zehra, S. Pyrethroid exposure: as determinant of CYP1A1 and GSTP1 genetic variations in occupationally exposed Sindh farmers. Biologia https:\/\/doi.org\/10.1007\/s11756-021-00698-w<\/a> (2021).<\/p>\n Article Google Scholar <\/p>\n Wadani, Z. H., Azam, I., Irfan, M. & Fatmi, Z. Pesticides use and impaired lung function among male agricultural farmers in rural Sindh, Pakistan. Asia Pac J Public Health https:\/\/doi.org\/10.1177\/10105395211065647<\/a> (2021).<\/p>\n Article PubMed Google Scholar <\/p>\n Ahmed, H., Sharif, A., Bakht, S., Javed, F. & Hassan, W. Persistent organic pollutants and neurological disorders: from exposure to preventive interventions. In Environmental Contaminants and Neurological Disorders (pp. 231247). Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-030-66376-6_11<\/a> (2021).<\/p>\n Ali, T. et al. Pesticide genotoxicity in cotton picking women in Pakistan evaluated using comet assay. Drug Chem. Toxicol. 41(2), 213220. https:\/\/doi.org\/10.1080\/01480545.2017.1343342<\/a> (2018).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Sandal, S. & Yilmaz, B. Genotoxic effects of chlorpyrifos, cypermethrin, endosulfan and 2,4-D on human peripheral lymphocytes cultured from smokers and nonsmokers. Environ. Toxicol. 26, 433442. https:\/\/doi.org\/10.1002\/tox.20569<\/a> (2011).<\/p>\n ADS CAS Article PubMed Google Scholar <\/p>\n Ambali, S. F. & Aliyu, M. B. Short-term sensorimotor and cognitive changes induced by acute chlorpyrifos exposure in Wistar rats: Ameliorative effect of vitamin E. Pharmacologia 3(2), 3138. https:\/\/doi.org\/10.5567\/pharmacologia2012.31.38<\/a> (2012).<\/p>\n CAS Article Google Scholar <\/p>\n Badr, A. M. Organophosphate toxicity: Updates of Malathion potential toxic effects in mammals and potential treatments. Environ. Sci. Pollut. Res. Int. 27, 2603626057. https:\/\/doi.org\/10.1007\/s11356-020-08937-4<\/a> (2020).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Ozkan, U. et al. Effects of intralipid and caffeic acid phenethyl ester on neurotoxicity, oxidative stress, and acetylcholinesterase activity in acute chlorpyriphos intoxication. Int. J. Clin. Exp. Med. 7(4), 837 (2014).<\/p>\n PubMed PubMed Central Google Scholar <\/p>\n Mehmood, Y., Arshad, M., Mahmood, N., Kchele, H. & Kong, R. Occupational hazards, health costs, and pesticide handling practices among vegetable growers in Pakistan. Environ. Res 200, 111340. https:\/\/doi.org\/10.1016\/j.envres.2021.111340<\/a> (2021).<\/p>\n CAS Article PubMed Google Scholar <\/p>\n Berridge, M. V., Herst, P. M. & Tan, A. S. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotech. Ann. Rev. 11, 127152. https:\/\/doi.org\/10.1016\/S1387-2656(05)11004-7<\/a> (2005).<\/p>\n CAS Article Google Scholar <\/p>\n Mathew, C. G. P. The isolation of high molecular weight eukaryotic DNA in nucleic acids methods in molecular Biology. Springer 9, 3134. https:\/\/doi.org\/10.1385\/0-89603-064-4:31<\/a> (1984).<\/p>\n ADS Article Google Scholar <\/p>\n Fong, C. S., Cheng, C. W. & Wu, R. M. Pesticides exposure and genetic polymorphism of Paraoxonase in the susceptibility of Parkinsons disease. Acta Neurol. Taiwan 14(2), 5560 (2005).<\/p>\n PubMed Google Scholar <\/p>\n <\/p>\n See the original post here: Sharma, A. et al. Global trends in pesticides: A looming threat and viable alternatives Continue reading
\nInsights of OPs and PYR cytotoxic potential Invitro and genotoxic impact on PON1 genetic variant among exposed workers in Pakistan | Scientific...<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"