{"id":1046205,"date":"2021-12-05T11:52:11","date_gmt":"2021-12-05T16:52:11","guid":{"rendered":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/uncategorized\/investigating-genetically-mimicked-effects-of-statins-via-hmgcr-inhibition-on-immune-related-diseases-in-men-and-women-using-mendelian-randomization\/"},"modified":"2021-12-05T11:52:11","modified_gmt":"2021-12-05T16:52:11","slug":"investigating-genetically-mimicked-effects-of-statins-via-hmgcr-inhibition-on-immune-related-diseases-in-men-and-women-using-mendelian-randomization","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/transhuman-news-blog\/eczema\/investigating-genetically-mimicked-effects-of-statins-via-hmgcr-inhibition-on-immune-related-diseases-in-men-and-women-using-mendelian-randomization\/","title":{"rendered":"Investigating genetically mimicked effects of statins via HMGCR inhibition on immune-related diseases in men and women using Mendelian randomization |&#8230;"},"content":{"rendered":"<p><p>Byrne, P., Cullinan, J. & Smith, S. M. Statins for primary prevention of cardiovascular disease. BMJ (Clin. Res. Ed.) 367, l5674. <a href=\"https:\/\/doi.org\/10.1136\/bmj.l5674\" rel=\"nofollow\">https:\/\/doi.org\/10.1136\/bmj.l5674<\/a> (2019).<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Sirtori, C. R. The pharmacology of statins. Pharmacol. Res. 88, 311. <a href=\"https:\/\/doi.org\/10.1016\/j.phrs.2014.03.002\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.phrs.2014.03.002<\/a> (2014).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Zhang, Q., Dong, J. & Yu, Z. Pleiotropic use of statins as non-lipid-lowering drugs. Int. J. Biol. Sci. 16, 27042711. <a href=\"https:\/\/doi.org\/10.7150\/ijbs.42965\" rel=\"nofollow\">https:\/\/doi.org\/10.7150\/ijbs.42965<\/a> (2020).<\/p>\n<p>Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Bedi, O., Dhawan, V., Sharma, P. L. & Kumar, P. Pleiotropic effects of statins: New therapeutic targets in drug design. Naunyn Schmiedeb. Arch. Pharmacol. 389, 695712. <a href=\"https:\/\/doi.org\/10.1007\/s00210-016-1252-4\" rel=\"nofollow\">https:\/\/doi.org\/10.1007\/s00210-016-1252-4<\/a> (2016).<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Khattri, S. & Zandman-Goddard, G. Statins and autoimmunity. Immunol. Res. 56, 348357. <a href=\"https:\/\/doi.org\/10.1007\/s12026-013-8409-8\" rel=\"nofollow\">https:\/\/doi.org\/10.1007\/s12026-013-8409-8<\/a> (2013).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Dehnavi, S. et al. Statins and autoimmunity: State-of-the-art. Pharmacol. Ther. 214, 107614. <a href=\"https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107614\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107614<\/a> (2020).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Li, G. M. et al. The anti-inflammatory effects of statins on patients with rheumatoid arthritis: A systemic review and meta-analysis of 15 randomized controlled trials. Autoimmun. Rev. 17, 215225. <a href=\"https:\/\/doi.org\/10.1016\/j.autrev.2017.10.013\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.autrev.2017.10.013<\/a> (2018).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Lv, S. et al. The impact of statins therapy on disease activity and inflammatory factor in patients with rheumatoid arthritis: A meta-analysis. Clin. Exp. Rheumatol. 33, 6976 (2015).<\/p>\n<p>PubMed                        Google Scholar                <\/p>\n<p>Naing, C. & Ni, H. Statins for asthma. Cochrane Database Syst. Rev. 7, 013268. <a href=\"https:\/\/doi.org\/10.1002\/14651858.CD013268.pub2\" rel=\"nofollow\">https:\/\/doi.org\/10.1002\/14651858.CD013268.pub2<\/a> (2020).<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Mammen, A. L. Statin-associated autoimmune myopathy. N. Engl. J. Med. 374, 664669. <a href=\"https:\/\/doi.org\/10.1056\/NEJMra1515161\" rel=\"nofollow\">https:\/\/doi.org\/10.1056\/NEJMra1515161<\/a> (2016).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Mammen, A. L. et al. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 63, 713721. <a href=\"https:\/\/doi.org\/10.1002\/art.30156\" rel=\"nofollow\">https:\/\/doi.org\/10.1002\/art.30156<\/a> (2011).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>de Jong, H. J. et al. Use of statins is associated with an increased risk of rheumatoid arthritis. Ann. Rheum. Dis. 71, 648654. <a href=\"https:\/\/doi.org\/10.1136\/ard.2011.155622\" rel=\"nofollow\">https:\/\/doi.org\/10.1136\/ard.2011.155622<\/a> (2012).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Smeeth, L., Douglas, I., Hall, A. J., Hubbard, R. & Evans, S. Effect of statins on a wide range of health outcomes: A cohort study validated by comparison with randomized trials. Br. J. Clin. Pharmacol. 67, 99109. <a href=\"https:\/\/doi.org\/10.1111\/j.1365-2125.2008.03308.x\" rel=\"nofollow\">https:\/\/doi.org\/10.1111\/j.1365-2125.2008.03308.x<\/a> (2009).<\/p>\n<p>Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Hippisley-Cox, J. & Coupland, C. Unintended effects of statins in men and women in England and Wales: Population based cohort study using the QResearch database. BMJ (Clin. Res. Ed.) 340, c2197. <a href=\"https:\/\/doi.org\/10.1136\/bmj.c2197\" rel=\"nofollow\">https:\/\/doi.org\/10.1136\/bmj.c2197<\/a> (2010).<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Jick, S. S., Choi, H., Li, L., McInnes, I. B. & Sattar, N. Hyperlipidaemia, statin use and the risk of developing rheumatoid arthritis. Ann. Rheum. Dis. 68, 546551. <a href=\"https:\/\/doi.org\/10.1136\/ard.2008.091967\" rel=\"nofollow\">https:\/\/doi.org\/10.1136\/ard.2008.091967<\/a> (2009).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Moon, J., Cohen Sedgh, R. & Jackevicius, C. Examining the nocebo effect of statins through statin adverse events reported in the FDA adverse event reporting system (FAERS). Circ. Cardiovasc. Qual. Outcomes. <a href=\"https:\/\/doi.org\/10.1161\/circoutcomes.120.007480\" rel=\"nofollow\">https:\/\/doi.org\/10.1161\/circoutcomes.120.007480<\/a> (2020).<\/p>\n<p>Article    PubMed                        Google Scholar                <\/p>\n<p>Ngo, S. T., Steyn, F. J. & McCombe, P. A. Gender differences in autoimmune disease. Front. Neuroendocrinol. 35, 347369. <a href=\"https:\/\/doi.org\/10.1016\/j.yfrne.2014.04.004\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.yfrne.2014.04.004<\/a> (2014).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Trigunaite, A., Dimo, J. & Jrgensen, T. N. Suppressive effects of androgens on the immune system. Cell. Immunol. 294, 8794. <a href=\"https:\/\/doi.org\/10.1016\/j.cellimm.2015.02.004\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.cellimm.2015.02.004<\/a> (2015).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Schooling, C. M., Au Yeung, S. L., Freeman, G. & Cowling, B. J. The effect of statins on testosterone in men and womenA systematic review and meta-analysis of randomized controlled trials. BMC Med. 11, 57. <a href=\"https:\/\/doi.org\/10.1186\/1741-7015-11-57\" rel=\"nofollow\">https:\/\/doi.org\/10.1186\/1741-7015-11-57<\/a> (2013).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Schooling, C. M., Zhao, J. V., Au Yeung, S. L. & Leung, G. M. Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation. Elife. <a href=\"https:\/\/doi.org\/10.7554\/eLife.58567\" rel=\"nofollow\">https:\/\/doi.org\/10.7554\/eLife.58567<\/a> (2020).<\/p>\n<p>Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Lawlor, D. A., Harbord, R. M., Sterne, J. A., Timpson, N. & Davey Smith, G. Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology. Stat. Med. 27, 11331163. <a href=\"https:\/\/doi.org\/10.1002\/sim.3034\" rel=\"nofollow\">https:\/\/doi.org\/10.1002\/sim.3034<\/a> (2008).<\/p>\n<p>MathSciNet    Article    PubMed                        Google Scholar                <\/p>\n<p>Cheung, K., Powers, E. M., McKillip, J. & Powers, J. G. Effect of statin use on incidence of eczema and atopic dermatitis: A retrospective cohort study. J. Am. Acad. Dermatol. <a href=\"https:\/\/doi.org\/10.1016\/j.jaad.2020.05.015\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.jaad.2020.05.015<\/a> (2020).<\/p>\n<p>Article    PubMed                        Google Scholar                <\/p>\n<p>Yuan, C. et al. Statins as potential therapeutic drug for asthma? Respir. Res. 13, 108. <a href=\"https:\/\/doi.org\/10.1186\/1465-9921-13-108\" rel=\"nofollow\">https:\/\/doi.org\/10.1186\/1465-9921-13-108<\/a> (2012).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Mehrpooya, M., Ghaed-Amini, F., Firozian, F., Mohammadi, Y. & Alirezaei, P. Beneficial effects of adding topical atorvastatin 5% cream to topical betamethasone 1% ointment on chronic hand eczema. Arch. Iran. Med. 23, 605613. <a href=\"https:\/\/doi.org\/10.34172\/aim.2020.71\" rel=\"nofollow\">https:\/\/doi.org\/10.34172\/aim.2020.71<\/a> (2020).<\/p>\n<p>Article    PubMed                        Google Scholar                <\/p>\n<p>Batty, G. D., Gale, C. R., Kivimki, M., Deary, I. J. & Bell, S. Comparison of risk factor associations in UK Biobank against representative, general population based studies with conventional response rates: Prospective cohort study and individual participant meta-analysis. BMJ (Clin. Res. Ed.) 368, m131. <a href=\"https:\/\/doi.org\/10.1136\/bmj.m131\" rel=\"nofollow\">https:\/\/doi.org\/10.1136\/bmj.m131<\/a> (2020).<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Nagai, A. et al. Overview of the BioBank Japan Project: Study design and profile. J. Epidemiol. 27, S2S8. <a href=\"https:\/\/doi.org\/10.1016\/j.je.2016.12.005\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.je.2016.12.005<\/a> (2017).<\/p>\n<p>Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Ishigaki, K. et al. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nat. Genet. 52, 669679. <a href=\"https:\/\/doi.org\/10.1038\/s41588-020-0640-3\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/s41588-020-0640-3<\/a> (2020).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Lopez, P. M., Subramanian, S. V. & Schooling, C. M. Effect measure modification conceptualized using selection diagrams as mediation by mechanisms of varying population-level relevance. J. Clin. Epidemiol. 113, 123128. <a href=\"https:\/\/doi.org\/10.1016\/j.jclinepi.2019.05.005\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.jclinepi.2019.05.005<\/a> (2019).<\/p>\n<p>Article    PubMed                        Google Scholar                <\/p>\n<p>Swerdlow, D. I. et al. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials. Lancet (London, England) 385, 351361. <a href=\"https:\/\/doi.org\/10.1016\/s0140-6736(14)61183-1\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/s0140-6736(14)61183-1<\/a> (2015).<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Khalid, F. & Holguin, F. A review of obesity and asthma across the life span. J. Asthma 55, 12861300. <a href=\"https:\/\/doi.org\/10.1080\/02770903.2018.1424187\" rel=\"nofollow\">https:\/\/doi.org\/10.1080\/02770903.2018.1424187<\/a> (2018).<\/p>\n<p>Article    PubMed                        Google Scholar                <\/p>\n<p>Fukutomi, Y. et al. Association between body mass index and asthma among Japanese adults: Risk within the normal weight range. Int. Arch. Allergy Immunol. 157, 281287. <a href=\"https:\/\/doi.org\/10.1159\/000327555\" rel=\"nofollow\">https:\/\/doi.org\/10.1159\/000327555<\/a> (2012).<\/p>\n<p>Article    PubMed                        Google Scholar                <\/p>\n<p>Glymour, M. M., Tchetgen Tchetgen, E. J. & Robins, J. M. Credible Mendelian randomization studies: Approaches for evaluating the instrumental variable assumptions. Am. J. Epidemiol. 175, 332339. <a href=\"https:\/\/doi.org\/10.1093\/aje\/kwr323\" rel=\"nofollow\">https:\/\/doi.org\/10.1093\/aje\/kwr323<\/a> (2012).<\/p>\n<p>Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Ference, B. A. et al. Mendelian randomization study of ACLY and cardiovascular disease. N. Engl. J. Med. 380, 10331042. <a href=\"https:\/\/doi.org\/10.1056\/NEJMoa1806747\" rel=\"nofollow\">https:\/\/doi.org\/10.1056\/NEJMoa1806747<\/a> (2019).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Schooling, C. M. et al. Use of multivariable Mendelian randomization to address biases due to competing risk before recruitment. Front Genet. 11, 610852. <a href=\"https:\/\/doi.org\/10.3389\/fgene.2020.610852\" rel=\"nofollow\">https:\/\/doi.org\/10.3389\/fgene.2020.610852<\/a> (2020).<\/p>\n<p>Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Ahmadi, M. et al. Pleiotropic effects of statins: A focus on cancer. Biochim. Biophys. Acta 1866, 165968. <a href=\"https:\/\/doi.org\/10.1016\/j.bbadis.2020.165968\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.bbadis.2020.165968<\/a> (2020).<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Kanai, M. et al. Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. Nat. Genet. 50, 390400. <a href=\"https:\/\/doi.org\/10.1038\/s41588-018-0047-6\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/s41588-018-0047-6<\/a> (2018).<\/p>\n<p>CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Han, Y. et al. Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma. Nat. Commun. 11, 1776. <a href=\"https:\/\/doi.org\/10.1038\/s41467-020-15649-3\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/s41467-020-15649-3<\/a> (2020).<\/p>\n<p>ADS    CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Okada, Y. et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, 376381. <a href=\"https:\/\/doi.org\/10.1038\/nature12873\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/nature12873<\/a> (2014).<\/p>\n<p>ADS    CAS    Article    PubMed                        Google Scholar                <\/p>\n<p>Tsoi, L. C. et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat. Genet. 44, 13411348. <a href=\"https:\/\/doi.org\/10.1038\/ng.2467\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/ng.2467<\/a> (2012).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Onengut-Gumuscu, S. et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat. Genet. 47, 381386. <a href=\"https:\/\/doi.org\/10.1038\/ng.3245\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/ng.3245<\/a> (2015).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Bentham, J. et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat. Genet. 47, 14571464. <a href=\"https:\/\/doi.org\/10.1038\/ng.3434\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/ng.3434<\/a> (2015).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Beecham, A. H. et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat. Genet. 45, 13531360. <a href=\"https:\/\/doi.org\/10.1038\/ng.2770\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/ng.2770<\/a> (2013).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>de Lange, K. M. et al. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat. Genet. 49, 256261. <a href=\"https:\/\/doi.org\/10.1038\/ng.3760\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/ng.3760<\/a> (2017).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Lloyd-Jones, L. R., Robinson, M. R., Yang, J. & Visscher, P. M. Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio. Genetics 208, 13971408. <a href=\"https:\/\/doi.org\/10.1534\/genetics.117.300360\" rel=\"nofollow\">https:\/\/doi.org\/10.1534\/genetics.117.300360<\/a> (2018).<\/p>\n<p>CAS    Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Bowden, J. et al. Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: The role of the I2 statistic. Int. J. Epidemiol. 45, 19611974. <a href=\"https:\/\/doi.org\/10.1093\/ije\/dyw220\" rel=\"nofollow\">https:\/\/doi.org\/10.1093\/ije\/dyw220<\/a> (2016).<\/p>\n<p>Article    PubMed    PubMed Central                        Google Scholar                <\/p>\n<p>Freeman, G., Cowling, B. J. & Schooling, C. M. Power and sample size calculations for Mendelian randomization studies using one genetic instrument. Int. J. Epidemiol. 42, 11571163. <a href=\"https:\/\/doi.org\/10.1093\/ije\/dyt110\" rel=\"nofollow\">https:\/\/doi.org\/10.1093\/ije\/dyt110<\/a> (2013).<\/p>\n<p>Article    PubMed                        Google Scholar                <\/p>\n<p><!-- Auto Generated --><\/p>\n<p>Read this article:<br \/>\n<a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41598-021-02981-x\" title=\"Investigating genetically mimicked effects of statins via HMGCR inhibition on immune-related diseases in men and women using Mendelian randomization |...\" rel=\"noopener\">Investigating genetically mimicked effects of statins via HMGCR inhibition on immune-related diseases in men and women using Mendelian randomization |...<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p> Byrne, P., Cullinan, J. &#038; Smith, S. M <a href=\"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/transhuman-news-blog\/eczema\/investigating-genetically-mimicked-effects-of-statins-via-hmgcr-inhibition-on-immune-related-diseases-in-men-and-women-using-mendelian-randomization\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[],"class_list":["post-1046205","post","type-post","status-publish","format-standard","hentry","category-eczema"],"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts\/1046205"}],"collection":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/comments?post=1046205"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts\/1046205\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/media?parent=1046205"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/categories?post=1046205"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/tags?post=1046205"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}