{"id":1024766,"date":"2021-08-18T07:48:56","date_gmt":"2021-08-18T11:48:56","guid":{"rendered":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/uncategorized\/the-prevalence-of-inorganic-mercury-in-human-cells-increases-during-aging-but-decreases-in-the-very-old-scientific-reports-nature-com\/"},"modified":"2021-08-18T07:48:56","modified_gmt":"2021-08-18T11:48:56","slug":"the-prevalence-of-inorganic-mercury-in-human-cells-increases-during-aging-but-decreases-in-the-very-old-scientific-reports-nature-com","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/transhuman-news-blog\/human-longevity\/the-prevalence-of-inorganic-mercury-in-human-cells-increases-during-aging-but-decreases-in-the-very-old-scientific-reports-nature-com\/","title":{"rendered":"The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old | Scientific Reports &#8211; Nature.com"},"content":{"rendered":"<p><p>Garagnani, P. et al. Whole-genome sequencing analysis of semi-supercentenarians. Elife 10, e57849 (2021).<\/p>\n<p>PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Sorrentino, J. A., Sanoff, H. K. & Sharpless, N. E. Defining the toxicology of aging. Trends Mol. Med. 20, 375384 (2014).<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Stohs, S. J. & Bagchi, D. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 18, 321336 (1995).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Crespo-Lopez, M. E. et al. Mercury and human genotoxicity: Critical considerations and possible molecular mechanisms. Pharmacol. Res. 60, 212220 (2009).<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Pollard, K. M., Cauvi, D. M., Toomey, C. B., Hultman, P. & Kono, D. H. Mercury-induced inflammation and autoimmunity. Biochim. Biophys. Acta Gen. Subj. 1863, 129299 (2019).<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Kennedy, B. K. et al. Geroscience: Linking aging to chronic disease. Cell 159, 709713 (2014).<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Franceschi, C. et al. The continuum of aging and age-related diseases: Common mechanisms but different rates. Front. Med. (Lausanne) 5, 61 (2018).<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Streets, D. G. et al. All-time releases of mercury to the atmosphere from human activities. Environ. Sci. Technol. 45, 1048510491 (2011).<\/p>\n<p>ADS    CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Clarkson, T. W. & Magos, L. The toxicology of mercury and its chemical compounds. Crit. Rev. Toxicol. 36, 609662 (2006).<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Charleston, J. S. et al. Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure. Toxicol. Appl. Pharmacol. 129, 196206 (1994).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Vahter, M. et al. Speciation of mercury in the primate blood and brain following long-term exposure to methyl mercury. Toxicol. Appl. Pharmacol. 124, 221229 (1994).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Vahter, M. E. et al. Demethylation of methyl mercury in different brain sites of Macaca fascicularis monkeys during long-term subclinical methyl mercury exposure. Toxicol. Appl. Pharmacol. 134, 273284 (1995).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Teixeira, F. B. et al. Exposure to inorganic mercury causes oxidative stress, cell death, and functional deficits in the motor cortex. Front. Mol. Neurosci. 11, 125 (2018).<\/p>\n<p>PubMed    PubMed Central    Article    CAS                        Google Scholar                <\/p>\n<p>Danscher, G. & Moller-Madsen, B. Silver amplification of mercury sulfide and selenide: A histochemical method for light and electron microscopic localization of mercury in tissue. J. Histochem. Cytochem. 33, 219228 (1985).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Pamphlett, R., Bishop, D. P., Kum Jew, S. & Doble, P. A. Age-related accumulation of toxic metals in the human locus ceruleus. PLoSOne 13, e0203627 (2018).<\/p>\n<p>PubMed    PubMed Central    Article    CAS                        Google Scholar                <\/p>\n<p>Pamphlett, R., Kum Jew, S., Doble, P. A. & Bishop, D. P. Elemental analysis of aging human pituitary glands implicates mercury as a contributor to the somatopause. Front. Endocrinol. (Lausanne) 10, 419 (2019).<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Pamphlett, R., Doble, P. A. & Bishop, D. P. Mercury in the human thyroid gland: Potential implications for thyroid cancer, autoimmune thyroiditis, and hypothyroidism. PLoSOne 16, e0246748 (2021).<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Pamphlett, R., Doble, P. A. & Bishop, D. P. The prevalence of inorganic mercury in human kidneys suggests a role for toxic metals in essential hypertension. Toxics 9, 67 (2021).<\/p>\n<p>PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Pamphlett, R., Kum Jew, S., Doble, P. A. & Bishop, D. P. Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging. Sci. Rep. 11, 2961 (2021).<\/p>\n<p>ADS    CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Pamphlett, R. & Png, F. Y. Shrinkage of motor axons following systemic exposure to inorganic mercury. J. Neuropathol. Exp. Neurol. 57, 360366 (1998).<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Pamphlett, R., Colebatch, A. J., Doble, P. A. & Bishop, D. P. Mercury in pancreatic cells of people with and without pancreatic cancer. Int. J. Environ. Res. Public Health 17, 8990 (2020).<\/p>\n<p>CAS    PubMed Central    Article    PubMed                        Google Scholar                <\/p>\n<p>Chang, A. Y., Skirbekk, V. F., Tyrovolas, S., Kassebaum, N. J. & Dieleman, J. L. Measuring population ageing: An analysis of the Global Burden of Disease Study 2017. Lancet Public Health 4, e159e167 (2019).<\/p>\n<p>PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Benarroch, E. E. Locus coeruleus. Cell Tissue Res. 373, 221232 (2018).<\/p>\n<p>PubMed    Article                        Google Scholar                <\/p>\n<p>Pamphlett, R. et al. Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus. PLoSOne 15, e0233300 (2020).<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Rudman, D. et al. Effects of human growth hormone in men over 60 years old. N. Engl. J. Med. 323, 16 (1990).<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Seravalle, G. & Grassi, G. Sympathetic nervous system, hypertension, obesity and metabolic syndrome. High Blood Press. Cardiovasc. Prev. 23, 175179 (2016).<\/p>\n<p>CAS    PubMed    Article                        Google Scholar                <\/p>\n<p>Barbi, E., Lagona, F., Marsili, M., Vaupel, J. W. & Wachter, K. W. The plateau of human mortality: Demography of longevity pioneers. Science 360, 14591461 (2018).<\/p>\n<p>ADS    MathSciNet    CAS    PubMed    PubMed Central    MATH    Article                        Google Scholar                <\/p>\n<p>Gampe, J. Mortality of Supercentenarians: Estimates from the Updated IDL. In Exceptional Lifespans (eds Maier, H., Jeune, B., & Vaupel, J. W.) Ch. 3, 2935 (Springer, 2021).<\/p>\n<p>Holland, D., Desikan, R. S., Dale, A. M. & McEvoy, L. K. Rates of decline in Alzheimer disease decrease with age. PLoSOne 7, e42325 (2012).<\/p>\n<p>ADS    CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Hirsch, L., Jette, N., Frolkis, A., Steeves, T. & Pringsheim, T. The incidence of Parkinsons disease: A systematic review and meta-analysis. Neuroepidemiology 46, 292300 (2016).<\/p>\n<p>PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Logroscino, G. et al. Incidence of amyotrophic lateral sclerosis in Europe. J. Neurol. Neurosurg. Psychiatry 81, 385390 (2010).<\/p>\n<p>PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Monnet-Tschudi, F., Zurich, M. G., Boschat, C., Corbaz, A. & Honegger, P. Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases. Rev. Environ. Health 21, 105117 (2006).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Smith, D. W. Cancer mortality at very old ages. Cancer 77, 13671372 (1996).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Harding, C., Pompei, F., Lee, E. E. & Wilson, R. Cancer suppression at old age. Cancer Res. 68, 44654478 (2008).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>International Agency for Research on Cancer. Mercury and mercury compounds. IARC Monogr. Eval. Carcinog. Risks Hum. 58, 239345 (1993).<\/p>\n<p>                    Google Scholar                <\/p>\n<p>Nersesyan, A. et al. Results of micronucleus assays with individuals who are occupationally and environmentally exposed to mercury, lead and cadmium. Mutat. Res. 770, 119139 (2016).<\/p>\n<p>CAS    Article                        Google Scholar                <\/p>\n<p>Noureldine, S. I. & Tufano, R. P. Association of Hashimotos thyroiditis and thyroid cancer. Curr. Opin. Oncol. 27, 2125 (2015).<\/p>\n<p>PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Kim, C. S. et al. Association of hypertension and blood pressure with kidney cancer risk: A nationwide population-based cohort study. Hypertension 75, 14391446 (2020).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Danscher, G. Light and electron microscopic localization of silver in biological tissue. Histochemistry 71, 177186 (1981).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Pamphlett, R. & Kum Jew, S. Age-related uptake of heavy metals in human spinal interneurons. PLoSOne 11, e0162260 (2016).<\/p>\n<p>PubMed    PubMed Central    Article    CAS                        Google Scholar                <\/p>\n<p>Pamphlett, R. & Kum Jew, S. Inorganic mercury in human astrocytes, oligodendrocytes, corticomotoneurons and the locus ceruleus: Implications for multiple sclerosis, neurodegenerative disorders and gliomas. Biometals 31, 807819 (2018).<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Pamphlett, R. et al. The distribution of toxic metals in the human retina and optic nerve head: Implications for age-related macular degeneration. PLoSOne 15, e0241054 (2020).<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Pamphlett, R., Kum Jew, S. & Cherepanoff, S. Mercury in the retina and optic nerve following prenatal exposure to mercury vapor. PLoSOne 14, e0220859 (2019).<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Pamphlett, R., Satgunaseelan, L., Kum Jew, S., Doble, P. A. & Bishop, D. P. Elemental bioimaging shows mercury and other toxic metals in normal breast tissue and in breast cancers. PLoSOne 15, e0228226 (2020).<\/p>\n<p>CAS    PubMed    PubMed Central    Article                        Google Scholar                <\/p>\n<p>Pamphlett, R. & Kum Jew, S. Mercury is taken up selectively by cells involved in joint, bone, and connective tissue disorders. Front. Med. (Lausanne) 6, 168 (2019).<\/p>\n<p>Article                        Google Scholar                <\/p>\n<p>Danscher, G., Horsted-Bindslev, P. & Rungby, J. Traces of mercury in organs from primates with amalgam fillings. Exp. Mol. Pathol. 52, 291299 (1990).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Warfvinge, K. & Bruun, A. Mercury distribution in the squirrel monkey retina after in Utero exposure to mercury vapor. Environ. Res. 83, 102109 (2000).<\/p>\n<p>CAS    PubMed    Article    PubMed Central                        Google Scholar                <\/p>\n<p>Parkin Kullmann, J. A. & Pamphlett, R. A comparison of mercury exposure from seafood consumption and dental amalgam fillings in people with and without amyotrophic lateral sclerosis (ALS): An international online case-control study. Int. J. Environ. Res. Public Health 15, 2874 (2018).<\/p>\n<p>CAS    PubMed Central    Article                        Google Scholar                <\/p>\n<p><!-- Auto Generated --><\/p>\n<p>More here:<br \/>\n<a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41598-021-96359-8\" title=\"The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old | Scientific Reports - Nature.com\" rel=\"noopener\">The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old | Scientific Reports - Nature.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p> Garagnani, P. et al. Whole-genome sequencing analysis of semi-supercentenarians <a href=\"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/transhuman-news-blog\/human-longevity\/the-prevalence-of-inorganic-mercury-in-human-cells-increases-during-aging-but-decreases-in-the-very-old-scientific-reports-nature-com\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-1024766","post","type-post","status-publish","format-standard","hentry","category-human-longevity"],"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts\/1024766"}],"collection":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/comments?post=1024766"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/posts\/1024766\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/media?parent=1024766"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/categories?post=1024766"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/prometheism-transhumanism-posthumanism\/wp-json\/wp\/v2\/tags?post=1024766"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}