Local treatment with topical creams featuring a mild alkaline pH could be helpful in reducing eczema-related skin inflammation in patients with mild atopic dermatitis (AD), a study published in the Journal of Cosmetic Dermatology suggests.<\/p>\n
The single-arm, open-label study enrolled 25 patients (median age, 22.5 years) with mild AD and eczema who were not using topical or systemic glucocorticoids and\/or antihistamines. Treatment consisted of Alkaline Build Up Caring Cream INTENSIVE and Alkaline Build Up Caring Cream PLUS+ (Siriderma) for 8 weeks. The patented INTENSIVE cream product contains 25% zinc oxide and 1% sulfur and are combined in a mild alkaline environment with high levels of multiunsaturated fatty acids. Likewise, the AC PLUS+ product contains small amounts of both zinc oxide and colloidal silver.<\/p>\n
At baseline and at 8 weeks, patients underwent dermatological, biochemical, and questionnaire-based examinations. Intensity and extension of AD were assessed using the objective SCORAD index, skin pH was measured using a skin planar glass electrode pH meter, and blood samples were taken to examine inflammatory markers.<\/p>\n
At baseline, the mean pH on the skin surface was 5.96. There was a small and insignificant 3.8% increase in pH after 8 weeks of treatment with the alkaline creams (P =.15). The researchers noted that this finding was important, given the role of pH in maintaining the outermost skin barrier function as well as the skin microbiome.<\/p>\n
At 8 weeks, there was an approximately 30% decrease in total eczematous-affected skin area (P =.025). There were also significant reductions in average severity scores for erythema (P <.001), desquamation (P <.001), and lichenification (P <.001) by 8 weeks. In addition, there was a small increase in interleukin-8 by 8 weeks (7.48 vs 8.52 pg\/mL; P =.037).<\/p>\n
Patients also reported a 62.8% decrease in itching (P <.001), a 68.1% decrease in redness (P <.001), a 59.6% decrease in skin dryness (P <.001), and a 66.7% decrease in skin cracking (P =.002) by the end of treatment.<\/p>\n
Limitations of this study included its lack of a control arm, the small sample size, and its open-label design.<\/p>\n
The investigators concluded that this topical local therapy alone or in combination with other anti-inflammatory drugs might represent an interesting and beneficial option for this diagnosis for which, to date, no curative treatment is available.<\/p>\n
Jurecek L, Rajcigelova T, Kozarova A, et al. Beneficial effects of an alkaline topical treatment in patients with mild atopic dermatitis. J Cosmet Dermatol. doi:10.1111\/jocd.13936<\/p>\n
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Originally posted here: Local treatment with topical creams featuring a mild alkaline pH could be helpful in reducing eczema-related skin inflammation in patients with mild atopic dermatitis (AD), a study published in the Journal of Cosmetic Dermatology suggests. The single-arm, open-label study enrolled 25 patients (median age, 22.5 years) with mild AD and eczema who were not using topical or systemic glucocorticoids and\/or antihistamines. Treatment consisted of Alkaline Build Up Caring Cream INTENSIVE and Alkaline Build Up Caring Cream PLUS+ (Siriderma) for 8 weeks. Continue reading
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