Beijing biotech lab Sinogene say they have successfully cloned a genetically-modified dog for medical research, and now plan to use the same technology to create "superdogs" for Chinese police.
The beagle puppy named Longlong, born in May, is a clone of a gene-edited beagle called Apple.
These two dogs are 99.9 per cent the same. We've observed their personality and appearance, even their facial expressions are identical. As you can see they're both very naughty and active. Even the way they walk, how they move around, says Mi Jidong, Sinogene General Manager.
Two other clone puppies Nuonuo and Qiqi followed Longlong in June. All were born from surrogate mothers in the lab.
Apple, the original beagle, was genetically modified last year using a gene-editing tool known as CRISPR/Cas9.
Clone puppies Nuonuo and Qiqi were born in May.
Its been more than 20 years since the first mammal, a sheep named Dolly, was cloned in 1996. Since then other animals, including horses and pigs, have since been cloned. The first dog, however, was only duplicated in 2005.
Dogs are extremely difficult to work with. Some cells are very complex and difficult to clone. Also its extremely hard for a dog embryo to survive in lab conditions, its very vulnerable, explains Mr Mi.
Another reason the cloning of dogs may be more difficult is that the animal is more genetically similar to humans than other animals. Approximately 400 out of 900 genetic illnesses in dogs are similar to human diseases.
Its for this reason that Apple, Longlong and his fellow-clones will be used primarily for medical research.
It's the first step in our future development to delve further into modifying dogs for medical research, says Mr Mi.
Apple was gene-edited to have several times higher levels of blood lipid a trait associated with high cholesterol. Sinogene say theyre cooperating with other labs in China to study gene-based diseases including heart disease and diabetes and develop medicines.
Scientist Mi Jidong plays with Sinogene's cloned puppies from a gene-edited beagle.
But thats not the only focus of the lab. Sinogene will also be using the same gene-editing and cloning technique to create super dogs for the police force as early as next year.
Were also exploring how we can use genetic modification and cloning to improve the specific qualities of different working dogs. For example to improve their stamina, their intelligence to make it easier to train them And also give them a better sense of smell, says Mr Mi.
China currently imports many of its police, search and rescue dogs. Mr Mi believes Sinogenes work could save money and improve the quality of Chinas police dog pack.
But the work has been condemned as cruel by animal welfare groups operating in China.
Cloning has many problems. Large numbers of animals are used as donors and surrogates. But the success rate is very small. So its a huge waste of animal life, says Peter Li, China Policy specialist at Humane Society International, and Associate Professor of East Asian Politics at the University of Houston-Downtown.
He says money would be better spent caring for Chinas millions of unwanted dogs.
I think this super dog work is suspect. Dogs are already very intelligent. We know that cloned dogs have health issues, they dont live long. It is a huge waste of public resources to clone dogs for the police force, says Professor Li.
Beijing-based animal rights activist Mary Peng believes medical testing on animals needs to be better regulated
Animal welfare activist and founder of Chinas first international animal hospital in Beijing, Mary Peng, says she doesnt feel animal medical testing should stop but says labs need to be better regulated. Cloning is really just another form of breeding, says Ms Peng. But I share concerns of how the animals are treated.
She says though China has progressed rapidly in recent years when it comes to the treatment and general attitude towards animals, protective laws lag behind international standards.
China is having the worlds biggest love affair with their pets in the history of the world, she says, but this is all very new, less than 25 years old maybe.
And this experimentation, medical research etc, are also really new industries for China, Ms Peng says. And Im not sure that the laws and regulations about how the animals are treated while theyre in these labs have been fully developed.
But Professor Li says the labs work also raises larger ethical questions. If we see cloned animals as a testing object, I wonder how soon this work will be applied to humans. If we have this level of audacity, this level of recklessness as a standard, then many other test labs will do things that should be stopped.
Sinogene scientist works with dog cells in their Beijing lab
Retired Tsinghua University artificial intelligence and ethics expert Professor Zhao Nanyuan dismisses the criticism of animal rights groups as foreign and irrelevant, saying Chinas scientific progress outweighs the cost.
To see human-animal relations as an ethical question is a concept borrowed from Western religion. In Chinese ethics we dont have this.
He says many in China, like him, will focus on the long-term benefit, rather than the individual treatment of an animal or embryo.
In China we have less problems developing genetically modified technology. Im pretty sure other countries will be behind China when it comes to human genetic research because of their concerns."
Read the rest here:
- Browns Odell Beckham Jr. said it was his dream to be teammates with Tom Brady - The Boston Globe - October 24th, 2019
- Aliens Already Invaded Earth With Tiny Probes, New Study Claims - International Business Times - October 24th, 2019
- The future of tequila: How clones, bats and biodiversity will help agave survive - The Dallas Morning News - October 22nd, 2019
- Tom Brady and Bob Kraft get the last laugh with quarterbacks cameo in Netflix series - The Boston Globe - October 22nd, 2019
- Living With Yourself Finale Recap: Me, Myself, and You - Vulture - October 20th, 2019
- Muskegon-area Week 8 football picks: With 2 blockbusters, cloning is appealing - MLive.com - October 20th, 2019
- Eminem 'cloned' conspiracy explodes after rapper releases track 'exposing theory' - Daily Star - October 20th, 2019
- Apple Card user says they were a victim of fraud despite never using their physical card - iMore - October 20th, 2019
- Intact Genomics Awarded the Patent of Fungal Artificial Chromosome Technologies - Suburban Journals - September 26th, 2019
- 'Star Wars 9' theory explains Snoke, Rey, and Palps return all at once - Inverse - September 26th, 2019
- Number plate cloning how you could get stung - RACQ Live - August 25th, 2017
- Crooks cloning number plates to lump innocent drivers with fines - 9news.com.au - August 25th, 2017
- Three arrested in Uttarakhand for withdrawing Rs 37 lakh by cloning ... - The New Indian Express - August 25th, 2017
- Cloning Couture | Exploring the world of couture sewing - August 20th, 2017
- Cloning of debit, credit cards: Key accused held, search on for 4 ... - The Indian Express - August 20th, 2017
- Ghana national held for withdrawing money by cloning ATM cards - India Today - August 18th, 2017
- Physicists measure complementary properties using quantum clones - Phys.Org - August 16th, 2017
- Nigerian held for duping Delhiites by cloning cards at ATMs | Delhi ... - Times of India - August 16th, 2017
- Disgraced Korean scientist Hwang Woo-suk loses legal battle over mammoth cloning tech - The Korea Herald - August 15th, 2017
- 'Card cloning' device puts key card entry at risk - WTHR - August 15th, 2017
- Using 'tap and go' will protect against fraud through 'ghost' EFTPOS terminals, police say - ABC Online - August 15th, 2017
- CRISPR-Cleaned Piglets Have Been Cloned for Organ Donation - Big Think - August 15th, 2017
- Fast facts about cloning - WPSD Local 6: Your news, weather, and sports authority - WPSD Local 6 - August 13th, 2017
- Orphan Black is ending, but how far has human cloning come? - The Verge - August 11th, 2017
- Over 50 Nalasopara residents lose Rs 10 lakh to debit card cloning - Times of India - August 11th, 2017
- Scientists are Getting Closer To Using Pig Organs For Human Transplants - TIME - August 11th, 2017
- Porsche 911-Look Fiat 500 Is Like A Cloning Experiment Gone Wrong - Motor1.com - August 8th, 2017
- VACC warns of number-plate cloning scam, motorists left to prove innocence - CarAdvice - August 8th, 2017
- How to clone a hard drive or SSD - PC Gamer - August 8th, 2017
- A natural gas boom in the Adriatic has created teeming nurseries of self-cloning baby jellyfish - Quartz - August 6th, 2017
- Here's the list of some of the famous living creatures that were patented - Economic Times - August 6th, 2017
- Playing with Fire: Trump's Iran Policy Risks Cloning North Korea - International Policy Digest (press release) (blog) - August 5th, 2017
- Trump's Iran Policy Risks Cloning North Korea - Fair Observer - August 4th, 2017
- That dream bike may not be the bargain you hoped for as the number plates may be cloned - Leicester Mercury - August 4th, 2017
- Cloning, Counterfeiting and Fraud in digital payments what to know to stay safe - Technology Zimbabwe - August 3rd, 2017
- The Extinct Horses of Great Abaco Island May Live Again - Atlas Obscura - July 31st, 2017
- LG vice president's phone SIM and credit cards cloned, duped of Rs 6 lakh - Hindustan Times - July 30th, 2017
- Competent Cells Market to Reach $2.2 Billion by 2022 - Analysis By Type, Application, End User & Region - PR Newswire (press release) - July 26th, 2017
- Date palm cloning ensures traditional UAE industry has a sweet future - The National - July 24th, 2017
- Asda Kingswood speak out after card cloning reports at store's petrol station - Hull Daily Mail - July 21st, 2017
- Men accused of cloning credit cards arrested in Bossier City | News ... - KTBS - July 21st, 2017
- Four including ex-employees of PVR arrested for card cloning - Hindustan Times - July 19th, 2017
- Nigerian held for cloning of debit cards - Times of India - July 18th, 2017
- Ukhand: Over 50 duped in ATM card cloning, STF to probe | Latest ... - Daily News & Analysis - July 18th, 2017
- How does cloning work, anyway? Your guide to real-world replication - Yahoo News - July 17th, 2017
- Midas, Cloning and the quest for eternal life - The New Indian Express - July 15th, 2017
- How does cloning work, anyway? Your guide to real-world replication - Digital Trends - July 15th, 2017
- Multiplex workers in card cloning racket - Times of India - Times of India - July 15th, 2017
- Former employees of multiplex arrested for cloning cards at ... - Hindustan Times - July 15th, 2017
- Two Nigerians with expired visas held for card cloning - Times of India - July 14th, 2017
- Genetically - Sputnik International - July 14th, 2017
- This is how to spot a card-cloning device at your ATM - JOE - July 12th, 2017
- Katie Price KNEW Jane Poutney was 'cloning into her' before she had affair with Kieran Hayler - Mirror.co.uk - July 12th, 2017
- First Gene-Edited Dog Cloned in China Raises Ethical Concerns - Sixth Tone - July 10th, 2017
- SilverStone TS12C Dual Docking and Cloning Station Review - eTeknix - July 10th, 2017
- Delhi gets 15 card cloning cases each month - Times of India - July 8th, 2017
- Better than CRISPR? LASSO Cloning ropes in Long-Read DNA - Labiotech.eu (blog) - July 8th, 2017
- Mumbai man booked for card cloning racket - Times of India - July 8th, 2017
- 5 Reasons to Think Twice About Animal Cloning - Care2.com - July 7th, 2017
- Farzi Cafe staff held for cloning cards, siphoning off Rs 6 Lakh - Daily News & Analysis - July 7th, 2017
- Facebook is reportedly cloning group video chat app Houseparty - TechSpot - July 7th, 2017
- Caf staff booked for cloning cards - The Hindu - The Hindu - July 5th, 2017
- Robotic Pig Cloning in China Considered Successful - China Christian Daily - July 5th, 2017
- Copy-Craps: The 15 Worst Comic Book Clones - CBR (blog) - July 4th, 2017
- Mumbaiites beware, your waiter might be cloning your card while you make payment at a hotel - Hindustan Times - July 4th, 2017
- Don't hand over your credit or debit card to waiters in Mumbai, some sell details for 1000 each - Hindustan Times - July 3rd, 2017
- Fraud Expert: Credit Card Cloning Trend "Going Skyward" - WFYI - June 30th, 2017
- Youth's arrest unearthed card cloning fraud - Times of India - June 30th, 2017
- Cloning Thousands of Genes for Massive Protein Libraries - Lab Manager Magazine - June 29th, 2017
- Yves Tumor's New Music Video is a Creepy Story of Cloning & Biohacking - Out Magazine - June 28th, 2017
- To find new drugs, make 'libraries' from DNA - Futurity: Research News - June 28th, 2017
- This powerful new tool for cloning genes could speed up drug discovery - Boston Business Journal - June 27th, 2017
- Three waiters arrested in Mumbai for fraud and cloning ATM cards ... - Hindustan Times - June 26th, 2017
- Puppies cloned from ears arrive in Russia for genetic research ... - RT - June 24th, 2017
- Cloning to the rescue - New Scientist - June 15th, 2017
- Cloning To Revive Abaco Wild Horses - Bahamas Tribune - June 15th, 2017
- Cloning Yourself in Photos or Videos - Fstoppers - June 10th, 2017
- Hackers caught cloning activist Twitter accounts to spread fake news ... - The Independent - June 10th, 2017
- Cloning Grapes Will Save Australian Wine - National Geographic Australia - June 8th, 2017
- Five Rules For Successful Marijuana Cloning - June 7th, 2017