{"id":82584,"date":"2012-11-11T07:44:32","date_gmt":"2012-11-11T07:44:32","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/longevity-medicine\/promoting-remyelination-by-blocking-hyaluronidase.php"},"modified":"2024-08-17T16:55:51","modified_gmt":"2024-08-17T20:55:51","slug":"promoting-remyelination-by-blocking-hyaluronidase","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/promoting-remyelination-by-blocking-hyaluronidase.php","title":{"rendered":"Promoting Remyelination by Blocking Hyaluronidase"},"content":{"rendered":"

Myelin<\/a> is the material sheathing axons<\/a> in nerve cells. A number of conditions involve loss of myelin, such as multiple sclerosis (MS)<\/a>, but loss of myelin integrity occurs to a lesser degree for all of us as we age<\/a>, and is thought to contribute to the characteristic cognitive decline of later years. Thus research into ways to regenerate myelin sheathing<\/a> has broad potential application and is worth keeping an eye on:<\/p>\n

\n

We have identified a whole new target for drugs that might promote repair of the damaged brain in any disorder in which demyelination occurs<\/a>. Any kind of therapy that can promote remyelination could be an absolute life-changer for the millions of people suffering from MS and other related disorders.<\/p>\n

In 2005, [researchers] discovered that a sugar molecule, called hyaluronic acid<\/a>, accumulates in areas of damage in the brains of humans and animals with demyelinating brain and spinal cord lesions<\/a>. Their findings at the time [suggested] that hyaluronic acid itself prevented remyelination by preventing cells that form myelin from differentiating<\/a> in areas of brain damage. The new study shows that the hyaluronic acid itself does not prevent the differentiation of myelin-forming cells. Rather, breakdown products generated by a specific enzyme<\/a> that chews up hyaluronic acid – called a hyaluronidase<\/a> – contribute to the remyelination failure.<\/p>\n

This enzyme is highly elevated in MS patient brain lesions and in the nervous systems of animals with an MS-like disease. The research team [found] that by blocking hyaluronidase activity, they could promote myelin-forming cell differentiation and remyelination in the mice with the MS-like disease. Most significantly, the drug that blocked hyaluronidase activity led to improved nerve cell function. The next step is to develop drugs that specifically target this enzyme.<\/i><\/p>\n<\/blockquote>\n

Link: http:\/\/www.sciencedaily.com\/releases\/2012\/10\/121031151611.htm<\/a><\/span><\/p>\n

Source:
http:\/\/www.fightaging.org\/archives\/2012\/11\/promoting-remyelination-by-blocking-hyaluronidase.php<\/a><\/p>\n

Source:
http:\/\/www.longevitymedicine.tv\/promoting-remyelination-by-blocking-hyaluronidase\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Myelin is the material sheathing axons in nerve cells. A number of conditions involve loss of myelin, such as multiple sclerosis (MS), but loss of myelin integrity occurs to a lesser degree for all of us as we age, and … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-82584","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/82584"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=82584"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/82584\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=82584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=82584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=82584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}