Study question<\/p>\n
During controlled ovarian stimulation (COS), does the duration of premature serum progesterone (P) elevation before administration of hCG affect the outcomes of IVF\/ICSI embryo transfer (-ET) cycles?<\/p>\n
Summary answer<\/p>\n
The duration of the premature serum P elevation is inversely related to the clinical pregnancy rate of IVF\/ICSI-ET cycles.<\/p>\n
What is known and what this paper adds<\/p>\n
The majority of the previous studies only considered a single serum P measurement made on the day of hCG administration and the results of attempts to relate this to IVF\/ICSI-ET outcomes were controversial. However, the effect of the duration of premature serum P elevation before the hCG administration on the outcomes of IVF\/ICSI-ET cycles has not been studied well. Here we demonstrate that the duration of premature serum P elevation has a more significant inverse correlation than the absolute serum P concentration on the day of hCG administration with IVF\/ICSI-ET outcomes.<\/p>\n
Design<\/p>\n
It is a retrospective, single-centre cohort study. A total of 1784 IVF and\/or ICSI-ET cycles were included from October 2005 to June 2011.<\/p>\n
Participants and setting<\/p>\n
A total of 1784 patients underwent their IVF and\/or ICSI-ET cycles in a university hospital IVF unit. The inclusion criteria include (i) age between 20 and 42 years and (ii) eligible indications for COS before IVF\/ICSI.<\/p>\n
Main results and the role of chance<\/p>\n
The duration of premature serum P elevation to >1 ng\/ml is significantly inversely associated with the probability of clinical pregnancy (odds ratio = 0.773, 95% confidence interval: 0.660–0.891, P<\/I> < 0.001), after adjustment for possible confounders with multivariate logistic regression analysis. However, the significance of inverse correlation between the absolute serum P concentration on the day of hCG administration with clinical pregnancy rate decreased after adjustment.<\/p>\n
Bias, confounding and other reasons for caution<\/p>\n
The cutoff value we chose to define premature serum P elevation (P > 1.0 ng\/ml) might not be able to be applied to different immunoassay kits and study population. The retrospective nature of this study inevitably might be influenced by some selection bias.<\/p>\n
Generalizability to other populations<\/p>\n
Older patients (>42 years) are excluded from our study.<\/p>\n
Study funding\/competing interest(s)<\/p>\n
This study was supported in part by grants from the National Science Council (100-2314-B-002-022-MY3) and National Taiwan University Hospital (NTUH 100-S1555), Taipei, Taiwan. No competing interests are declared.<\/p>\n
Trial registration number<\/p>\n
nil.<\/p>\n
Source: Study question During controlled ovarian stimulation (COS), does the duration of premature serum progesterone (P) elevation before administration of hCG affect the outcomes of IVF\/ICSI embryo transfer (-ET) cycles? Summary answer The duration of the premature serum P elevation is … Continue reading
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