02.05.2012 - (idw) Max-Delbrck-Centrum fr Molekulare Medizin (MDC) Berlin-Buch <\/p>\n
People with good hearing also have a keen sense of touch; people with impaired hearing generally have an impaired sense of touch. Data supporting this hypothesis was presented by Dr. Henning Frenzel and Prof. Gary R. Lewin (Max Delbrck Center, MDC, Berlin). They showed that both senses have a common genetic basis. In patients with Usher syndrome, a hereditary form of deafness accompanied by impaired vision, they discovered a gene mutation that is also causative for the patients impaired touch sensitivity (PloS Biology doi:10.1371\/journal.pbio.1001318)*. The examination was preceded by various studies, including twin studies. In total, they assessed sensory function in 518 volunteers. People with good hearing also have a keen sense of touch; people with impaired hearing generally have an impaired sense of touch. Extensive data supporting this hypothesis was presented by Dr. Henning Frenzel and Professor Gary R. Lewin of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany. The two researchers showed that both senses hearing and touch have a common genetic basis. In patients with Usher syndrome, a hereditary form of deafness accompanied by impaired vision, they discovered a gene mutation that is also causative for the patients impaired touch sensitivity. The examination was preceded by various studies, including studies with healthy identical and non-identical human twins (PloS Biology, doi:10.1371\/journal.pbio.1001318)*. In total, the researchers assessed sensory function in 518 volunteers. <\/p>\n
In all vertebrates, and consequently also in humans, hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. When we hear, sound waves trigger vibrations that stimulate the hair-like nerve endings in the cochlea in the inner ear. These then transform the mechanical stimuli into electrical signals, which are transmitted to the brain via the auditory nerve. When we touch something a similar process takes place: The mechanical stimulus - sliding the fingers over a rough or smooth surface, the perception of vibrations - is taken up via sensors in the skin, converted into an electrical stimulus and transmitted to the brain. <\/p>\n
Twin study with 100 pairs of twins In recent years about 70 genes have been identified in humans, mutations in which trigger hearing loss or deafness. Surprisingly, no genes have been found that negatively influence the sense of touch, Professor Lewin said. To see whether the sense of touch also has a hereditary component, the researchers first studied 100 pairs of twins - 66 pairs of monozygotic twins and 34 dizygotic pairs of twins. Monozygotic twins are genetically completely identical; dizygotic twins are genetically identical to 50 percent. The tests showed that the touch sensitivity of the subjects was determined to more than 50 percent by genes. Furthermore, hearing and touch tests showed that there is a correlation between the sense of hearing and touch. <\/p>\n
The researchers therefore suspected that genes that influence the sense of hearing may also have an influence on the sense of touch. In a next step, they recruited test subjects at a school in Berlin for students with hearing impairments. There they assessed the touch sensitivity in a cohort of 39 young people who suffered from severe congenital hearing impairment. The researchers compared these findings with the data from their twin study and discovered that not all of the young people with hearing loss had impaired tactile acuity. Strikingly, however, many of these young people did indeed have poor tactile acuity, Professor Lewin explained. <\/p>\n
The researchers examined one cohort of patients in a special consultation at the Charit - Universittsmedizin Berlin for Usher patients from all over Germany. A second cohort was recruited at the university hospital La Fe in Valencia, Spain. The studies revealed that not all patients with Usher-syndrome have poor tactile acuity and touch sensitivity. The researchers showed that only patients with Usher syndrome who have a mutation in the gene USH2A have poor touch sensitivity. This mutation is also responsible for the impaired hearing of 19 patients. The 29 Usher-syndrome patients in whom the mutation could not be detected had a normal sense of touch. The researchers thus demonstrated that there is a common genetic basis for the sense of hearing and touch. They suspect that even more genes will be discovered in the future that influence both mechanosensory traits. <\/p>\n
Women hear better than men and have a finer sense of touch The researchers discovered another interesting detail during their five-year study. When women complain that their men are not really listening to them, there is some truth in that, Professor Lewin said. The studies with a total of 518 individuals including 295 women have actually shown that women hear better and they also have a finer sense of touch than men; in short woman hear and feel more than men! <\/p>\n
*A genetic basis for mechanosensory traits in humans Henning Frenzel1, Jrg Bohlender2, Katrin Pinsker2, Brbel Wohlleben2, Jens Tank3, Stefan G. Lechner1, Daniela Schiska2, Teresa Jaijo5, Franz Rueschendorf4, Kathrin Saar4, Jens Jordan3, Jos M. Milln5 and Manfred Gross2, Gary R. Lewin1,6 <\/p>\n
1Department of Neuroscience, Max Delbrck Center for Molecular Medicine, Robert-Rssle-Str. 10, Berlin-Buch D-13092 Germany, 2Department of Audiology and Phoniatrics, Charit, Universittsmedizin, Berlin, Augustenburger Platz 1, Berlin D-13353 Germany. 3Institute of Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover D-30625, Germany, 4Experimental genetics of cardiovascular disease, Max Delbrck Center for Molecular Medicine, Robert-Rssle-Str. 10, Berlin-Buch D-13092 Germany, 5Genetics Unit, Hospital Universitario La Fe, Avda. de Campanar, 21, 46009 and CIBERER, Valencia, Spain 6Author for Correspondence <\/p>\n
Contact: Press Department Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch in the Helmholtz Association Robert-Rssle-Strae 10; 13125 Berlin; Germany Phone: +49 (0) 30 94 06 - 38 96 Fax: +49 (0) 30 94 06 - 38 33 e-mail: presse@mdc-berlin.de<\/a> http:\/\/www.mdc-berlin.de\/<\/a> jQuery(document).ready(function($) { $(\"fb_share\").attr(\"share_url\") = encodeURIComponent(window.location); }); Weitere Informationen: http:\/\/www.nature.com\/neuro\/journal\/v15\/n1\/pdf\/nn.2985.pdf<\/a> <\/p>\n<\/p>\n See the original post here: 02.05.2012 - (idw) Max-Delbrck-Centrum fr Molekulare Medizin (MDC) Berlin-Buch People with good hearing also have a keen sense of touch; people with impaired hearing generally have an impaired sense of touch. Data supporting this hypothesis was presented by Dr. Henning Frenzel and Prof Continue reading
\nGene Mutation Leads to Impairment of Two Senses: Touch and Hearing<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"