Editor's Choice
Main Category: Neurology \/ Neuroscience
Article Date: 22 Feb 2012 - 5:00 PST <\/p>\n
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A study in rats has found that a new medication called clazosentan, may be effective in blocking the harmful effects of traumatic brain injury (TBI). The study will be presented at the American Academy of Neurology's 64th Annual Meeting in New Orleans April 21 to April 28, 2012. <\/p>\n
Michael Kaufman, study author, a second year medical student at Wayne State University School of Medicine in Detroit, and member of the American Academy of Neurology, explained: <\/p>\n
\"There are currently no primary treatments for TBI, so this research provides hope that effective treatments can be developed.\" <\/p>\n
Christian Kreipke, MD, also with Wayne State University School of Medicine, is lead researcher on the study. <\/p>\n
TBI results in restricted blood flow in the cerebrum of the brain, which can ultimately cause permanent cell dysfunction and death. As early as four hours following a brain injury, a receptor in the brain called endothelin receptor A (ETrA) contributes to decreasing blood flow. Scientists believe that the new drug clazosentan specifically blocks ETrA. <\/p>\n
Through an intravenous (IV) line, the team administered clazosentan to brain-injured rats at multiple time periods after TBI. The researchers then used an MRI brain scan to measure the rat's blood flow in the hippocampus and sensory motor cortex and examined their behavior in learning a maze. <\/p>\n
Four hours after TBI, results showed that the drug lowered the effects of the TBI on blood flow to the hippocampus by 25% and 23% at 48 hours. The researchers found that some rats improved when given the drug 12 hours post-TBI, while others remained the same or worsened. Results showed that the most effective time to administer clazosentan was 2 hours post-injury and again at 24 hours. When the medication was given at 2 and 24 hours post-injury, the rats also performed better on the maze test. <\/p>\n
Kaufman, said: <\/p>\n
\"This research is the foundation for future clinical trials that will investigate the possibilities of using clazosentan in the treatment of TBI.\" <\/p>\n
The study was funded by the American Academy of Neurology, the U.S. Department of Veterans Affairs, and the National Institutes of Health. <\/p>\n
To learn more about traumatic brain injury, click here. <\/p>\n
Written by Grace Rattue
Copyright: Medical News Today
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Grace Rattue. \"Traumatic Brain Injury - Clazosentan May Block Harmful Effects.\" Medical News Today. MediLexicon, Intl., 22 Feb. 2012. Web. APA <\/p>\n Please note: If no author information is provided, the source is cited instead. <\/p>\n Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information. <\/p>\n If you write about specific medications or operations, please do not name health care professionals by name. <\/p>\n All opinions are moderated before being included (to stop spam) <\/p>\n Contact Our News Editors <\/p>\n For any corrections of factual information, or to contact the editors please use our feedback form.<\/p>\n Please send any medical news or health news press releases to: <\/p>\n Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions. <\/p>\n Read more here: Editor's Choice Main Category: Neurology \/ Neuroscience Article Date: 22 Feb 2012 - 5:00 PST email to a friend printer friendly opinions Current Article Ratings: Patient \/ Public: Healthcare Prof: A study in rats has found that a new medication called clazosentan, may be effective in blocking the harmful effects of traumatic brain injury (TBI). The study will be presented at the American Academy of Neurology's 64th Annual Meeting in New Orleans April 21 to April 28, 2012. Michael Kaufman, study author, a second year medical student at Wayne State University School of Medicine in Detroit, and member of the American Academy of Neurology, explained: \"There are currently no primary treatments for TBI, so this research provides hope that effective treatments can be developed.\" Christian Kreipke, MD, also with Wayne State University School of Medicine, is lead researcher on the study. Continue reading
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