Silicon, which is less electronegative than carbon or hydrogen atoms, can significantly alter the electronic characteristics of an organic molecule. Replacing the hydrogen atoms of an aromatic C\u2013H group with silyl groups has emerged as an important strategy in industrial-scale chemical synthesis because these substituents can tune molecular reactivity, enabling construction of elaborate chemical frameworks. <\/p>\n
Chemists normally use transition metals such as platinum or rhodium to catalyze aromatic silylation reactions. But to achieve high conversions, these catalysts need to be mixed with additional hydrogen acceptor reagents, which can generate unwanted waste products, including alkanes. <\/p>\n
Hou and colleagues have pioneered studies into rare-earth metals, such as scandium, which have different catalytic properties to transition metals. Recently, they found that \u2018half-sandwich\u2019 scandium complexes, bonded on one side by a flat organic ring, showed unique activity and selectivity in the presence of carbon double bonds. This made investigations of unsaturated aromatic molecules a natural next step. <\/p>\n
When the researchers mixed a methoxy\u2013benzene compound called anisole with the half-sandwich scandium catalyst and a phenylsilane, they found that the silyl group substituted onto the aromatic ring with excellent selectivity and yields (Fig. 1). Furthermore, the catalyst did not require hydrogen acceptor reagents, and generated only H2 gas as a by-product. Hou notes that this reaction is highly advantageous in terms of atom economy. <\/p>\n
X-ray and spectroscopic measurements revealed that the working form of the catalyst, which contained a pair of \u2018bridging\u2019 hydrogen atoms, activated the reaction by coordinating the anisole\u2019s methoxy group to the rare-earth metal. According to Hou, this relatively strong interaction directs silylation to occur almost exclusively at the position adjacent to the methoxy unit on the aromatic ring\u2014a 'regioselectivity' that outshines that of transition metal catalysts, whose weak oxygen\u2013metal interactions often produce an undesirable mix of silylation isomers. <\/p>\n
The team will continue to explore new approaches to improving catalytic sustainability and selectivity by tapping into the extraordinary properties of rare-earth metals. <\/p>\n
More information: Oyamada, J., et al. Scandium-catalyzed silylation of aromatic C\u2013H bonds. Angewandte Chemie International Edition 50, 10720\u201310723 (2011). <\/p>\n
Takimoto, M., et al. Scandium-catalyzed regio- and stereospecific methylalumination of silyloxy\/alkoxy-substituted alkynes and alkenes. Journal of the American Chemical Society 131, 18266\u201318268 (2009). <\/p>\n
Provided by RIKEN (news : web) <\/p>\n<\/p>\n
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\nEconomizing chemistry, atom by atom<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"