{"id":5310,"date":"2010-01-14T13:04:41","date_gmt":"2010-01-14T13:04:41","guid":{"rendered":"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/cetp-jewish-centenarians-and-alzheimers\/"},"modified":"2010-01-14T13:04:41","modified_gmt":"2010-01-14T13:04:41","slug":"cetp-jewish-centenarians-and-alzheimers","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/genetic-medicine\/cetp-jewish-centenarians-and-alzheimers.php","title":{"rendered":"CETP, Jewish Centenarians and Alzheimers"},"content":{"rendered":"<p><span>2005, I am at a lecture in a small conference room in the Annenberg building at Mount Sinai. You know the building, the huge black imposing tower at 101st and Madison Ave.<\/span><\/p><div><span><br><\/span><\/div><div><span>The speaker, Nir Barzilai. The topic: Living to 100. The take away, people that live to 100 have better defenses against the toxic exposure we ingest daily.<\/span><\/div><div><span><br><\/span><\/div><div><span>The biggest molecule I learned about CETP. Yup, CETP. So naturally when I learn about something I do a pretty big deep dive. Which is why I went out and bought huge amounts of Pfizer stock when I found out they were making a CETP inhibitor.....what a flop that was......goes to show, not all pleiomorphic effects or unexpected adverse effects are good.......<\/span><\/div><div><span><br><\/span><\/div><div><span>So imagine my surprise when <a href=\"http:\/\/jama.ama-assn.org\/cgi\/content\/abstract\/299\/23\/2777?maxtoshow=&amp;HITS=10&amp;hits=10&amp;RESULTFORMAT=&amp;searchid=1&amp;FIRSTINDEX=30&amp;resourcetype=HWFIG\">@lindaavey @dgmacarthur <\/a>mention that <a href=\"http:\/\/pubs.ama-assn.org\/media\/2010j\/0112.dtl#2\">JAMA <\/a>has a study on it....I listen.<\/span><\/div><div><span><br><\/span><\/div><div><span>But what do I find? Well, basically what the alzheimer association finds<\/span><\/div><div><span><br><\/span><\/div><div><span><span>This relatively small study suggests that variations in this particular gene - linked with long life and lower risk of heart disease - could also be associated with <\/span><a href=\"http:\/\/www.alzheimers.org.uk\/site\/scripts\/documents.php?categoryID=200120\"><span>lower risk of dementia<\/span><\/a><span>. More research is needed to fully understand this link. The government currently invests eight times less in dementia research than cancer research. This needs to change.'<\/span><\/span><\/div><div><span><span><span><span><br><\/span><\/span><\/span><\/span><\/div><div><span><span><span><span>I think this may be too much attention towards a subject in an attempt to hype a genetic finding. I remain skeptical. Since after all, I was burned by  <a href=\"http:\/\/pipeline.corante.com\/archives\/2006\/12\/03\/the_torcetrapib_catastrophe.php\"> torcetrapib....<\/a>..<\/span><\/span><\/span><\/span><\/div><div><span><span><b><span><br><\/span><\/b><\/span><\/span><\/div><div><span><span><b><span>The Sherpa Says: Much ado right now, but certainly would be neat if we had some hard core modifier genes involved in APOE alzheimers....<\/span><\/b><\/span><\/span><\/div><div><img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/f019d_6173393362223742012-5776494892591835718?l=thegenesherpa.blogspot.com\" alt=\"\" style=\"padding-left:10px; padding-right: 10px;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>2005, I am at a lecture in a small conference room in the Annenberg building at Mount Sinai. You know the building, the huge black imposing tower at 101st and Madison Ave.The speaker, Nir Barzilai. The topic: Living to 100. &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/genetic-medicine\/cetp-jewish-centenarians-and-alzheimers.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-5310","post","type-post","status-publish","format-standard","hentry","category-genetic-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/5310"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=5310"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/5310\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=5310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=5310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=5310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}