{"id":48,"date":"2009-11-08T04:48:19","date_gmt":"2009-11-08T04:48:19","guid":{"rendered":"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/?p=48"},"modified":"2009-11-08T04:48:19","modified_gmt":"2009-11-08T04:48:19","slug":"2d6-rears-its-ugly-head","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/genetic-medicine\/2d6-rears-its-ugly-head.php","title":{"rendered":"2D6 Rears its ugly head….."},"content":{"rendered":"

\"\"<\/a>
Ok, I have been to hell and back......but I am back.......<\/span><\/p>

I am working on a video you all may soon love to hate, I am also working on a poster for GAPPNet which you too may also soon love to hate......<\/span><\/p>

Well, for all you Amplichip<\/a> fans, the data from a <\/span>recent retrospective analysis of German and US cohorts<\/a> reveals that null function 2D6 may actually portend a worse prognosis for those taking adjuvant (after surgery) chemotherapy for breast cancer. These are women who had hormone receptor positive breast cancer stages I-III, without metastases and without chermotherapy.<\/span><\/p>

At 9 years of follow up, patients who had null 2D6 CYP 450 enzymes ended up with a 29% recurrence rate instead of those who had active 2D6 enzymes. This compared to 14.9% for extensive metabolizers.<\/span><\/p>

Why does this matter? <\/span>
1. Tamoxifen is used a lot<\/span>
2. Aromatase inhibitor therapy (Another Drug) is another option for this type of cancer<\/span>
3. This test is easy to do<\/span>
4. This follows the Plavix model......<\/span><\/p>

My guess, Roche is about to make a lot of money on the Amplichip shortly.......<\/span><\/p>

Why is this study important? It is the first sufficiently powered study to assess 2D6 genotypes and outcomes.....<\/span><\/p>

Even more importantly, Tamoxifen is a Pro-Drug.....just like Plavix. This time it requires conversion to Endoxifen which is the active drug derived from Tamoxifen.......<\/span><\/p>

The hazard ration for recurrence with poor metabolizers is 2.12. That is a useful thing, which may prompt refined endocrine therapy for these postmenopausal breast cancers......<\/span><\/p>

The Sherpa Says: I am back!!!<\/span><\/p>

<\/div>","protected":false},"excerpt":{"rendered":"

Ok, I have been to hell and back......but I am back.......I am working on a video you all may soon love to hate, I am also working on a poster for GAPPNet which you too may also soon love to … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-48","post","type-post","status-publish","format-standard","hentry","category-genetic-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/48"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=48"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/48\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=48"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=48"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=48"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}