{"id":38966,"date":"2011-09-04T15:44:22","date_gmt":"2011-09-04T15:44:22","guid":{"rendered":"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/how-to-make-a-transparent-mouse-with-a-few-simple-ingredients-80beats\/"},"modified":"2011-09-04T15:44:22","modified_gmt":"2011-09-04T15:44:22","slug":"how-to-make-a-transparent-mouse-with-a-few-simple-ingredients-80beats","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/astronomy\/how-to-make-a-transparent-mouse-with-a-few-simple-ingredients-80beats.php","title":{"rendered":"How to Make a Transparent Mouse with a Few Simple Ingredients | 80beats"},"content":{"rendered":"<p><\/p><p><img decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/81501_transparent-mouse.jpg\" alt=\"embryos\" style=\"padding-left:10px; padding-right: 10px;\"><br>On the left: A mouse embryo preserved in para-formaldehyde. On the right: A mouse embryo soaked in Sca<em>l<\/em>e for two weeks.<\/p><p><strong>What&rsquo;s the News: <\/strong>The trouble with brains, organs, and tissues in general, from a biologist&rsquo;s perspective, is that they scatter light like nobody&rsquo;s business. Shine a light into there to start snapping pictures of cells with your microscope, and bam, all those proteins and macromolecules bounce it around and turn everything to static before you&rsquo;ve gotten more than a millimeter below the surface. Scientists at <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/en.wikipedia.org\/wiki\/RIKEN\">RIKEN<\/a> in Japan, however, have just published <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/www.nature.com\/neuro\/journal\/vaop\/ncurrent\/full\/nn.2928.html\">a special recipe<\/a> for a substance that makes tissue as transparent as Jell-O, making unprecedentedly deep imaging possible.<\/p><p><strong>How the Heck:<\/strong><\/p><p>Substances to make tissue more transparent are called clearing agents, and the ones we have now have varying degrees of penetration&mdash;in other words, they don&rsquo;t always take you as deep as you&rsquo;d like. To boot, they sometimes mess with the fluorescent tags that biologists splice into certain tissues to light up a particular set of blood vessels or neurons, for example.<br>This recipe clears out tissue so well that the only limitation on how deep you can see is the power of ...<\/p><p><a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/feedads.g.doubleclick.net\/~a\/h8DHxMWB7pF4C1QLmK_2FUicyM4\/0\/da\"><img decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/81501_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><br><a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/feedads.g.doubleclick.net\/~a\/h8DHxMWB7pF4C1QLmK_2FUicyM4\/1\/da\"><img decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/81501_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><\/p><p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/81501_QEhz3haih_I\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/81501_6eZP22uhfeg\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><\/p>","protected":false},"excerpt":{"rendered":"<p>On the left: A mouse embryo preserved in para-formaldehyde. On the right: A mouse embryo soaked in Scale for two weeks.What&rsquo;s the News: The trouble with brains, organs, and tissues in general, from a biologist&rsquo;s perspective, is that they scatter &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/astronomy\/how-to-make-a-transparent-mouse-with-a-few-simple-ingredients-80beats.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[21],"tags":[],"class_list":["post-38966","post","type-post","status-publish","format-standard","hentry","category-astronomy"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/38966"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=38966"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/38966\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=38966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=38966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=38966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}