{"id":37892,"date":"2011-08-07T15:46:42","date_gmt":"2011-08-07T15:46:42","guid":{"rendered":"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/the-social-goods-of-individual-actions-gene-expression\/"},"modified":"2011-08-07T15:46:42","modified_gmt":"2011-08-07T15:46:42","slug":"the-social-goods-of-individual-actions-gene-expression","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/astronomy\/the-social-goods-of-individual-actions-gene-expression.php","title":{"rendered":"The social goods of individual actions | Gene Expression"},"content":{"rendered":"<p>Over at <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/www.wired.com\/wiredcscience\/2011\/08\/what-will-be-the-consequences-of-prenatal-screening-for-serious-diseases\/\">Genetic Future<\/a> <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/www.wired.com\/wiredscience\/2011\/08\/what-will-be-the-consequences-of-prenatal-screening-for-serious-diseases\/\">Dr. Daniel MacArthur<\/a> has a measured response to a <i>Nature<\/i> commentary by <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/mgm.duke.edu\/faculty\/goldstein\/\">David Goldstein<\/a>, <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/www.nature.com\/nature\/journal\/v476\/n7358\/full\/476027a.html\">Growth of genome screening needs debate<\/a>. As Dr. MacArthur notes an excessive portion of Goldstein&rsquo;s piece is taken up with inferences derived from assuming that the model of <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/www.plosbiology.org\/article\/info:doi\/10.1371\/journal.pbio.1000294\">rare variants causing most diseases<\/a> is correct, when that is an issue currently in scientific contention (and this is a debate where Goldstein is a primary player on one side). But the last two paragraphs of the piece is where the real action is, no matter the details of genetic architecture of diseases:<\/p><blockquote><p>One potential problem with this is that numerous genetic risk factors will have diverse and unexpected effects &mdash; sometimes causing disease, sometimes being harmless and sometimes perhaps being associated with behaviours or characteristics that society deems positive. Even for simpler Mendelian diseases, up to 30% of the mutations originally termed pathogenic have turned out to be apparently harmless&hellip;<b>Wholesale elimination of variants associated with disease could end up influencing unexpected traits &mdash; increasing the vulnerability of populations to infectious diseases, for instance, or depleting people&rsquo;s creativity.<\/b><\/p><p>There are no clear-cut answers to the questions of what should be screened ...<img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/4401b_LGRT9AFsUfo\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><\/p><\/blockquote><p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/a08f0_6sSfLGaCPuw\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Over at Genetic Future Dr. Daniel MacArthur has a measured response to a Nature commentary by David Goldstein, Growth of genome screening needs debate. As Dr. MacArthur notes an excessive portion of Goldstein&rsquo;s piece is taken up with inferences derived &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/astronomy\/the-social-goods-of-individual-actions-gene-expression.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[21],"tags":[],"class_list":["post-37892","post","type-post","status-publish","format-standard","hentry","category-astronomy"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/37892"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=37892"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/37892\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=37892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=37892"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=37892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}