{"id":35730,"date":"2011-05-29T15:44:55","date_gmt":"2011-05-29T15:44:55","guid":{"rendered":"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/new-way-to-smuggle-drugs-into-brain-may-lead-to-better-alzheimer%e2%80%99s-treatments-80beats\/"},"modified":"2011-05-29T15:44:55","modified_gmt":"2011-05-29T15:44:55","slug":"new-way-to-smuggle-drugs-into-brain-may-lead-to-better-alzheimer%e2%80%99s-treatments-80beats","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/astronomy\/new-way-to-smuggle-drugs-into-brain-may-lead-to-better-alzheimer%e2%80%99s-treatments-80beats.php","title":{"rendered":"New Way to Smuggle Drugs Into Brain May Lead to Better Alzheimer\u2019s Treatments | 80beats"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-29264\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/194f6_pet_scan-425x445.jpg\" alt=\"\" width=\"425\" height=\"445\" style=\"padding-left:10px; padding-right: 10px;\"><strong>What&rsquo;s the News:<\/strong> A modified <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/en.wikipedia.org\/wiki\/Antibody\">antibody<\/a> can make its way into the brain and target the development of Alzheimer&rsquo;s-inducing plaques, researchers reported today in <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/stm.sciencemag.org\/content\/3\/84\/84ra44.abstract\">two<\/a> animal <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/stm.sciencemag.org\/content\/3\/84\/84ra43.abstract\">studies<\/a> in <em>Science Translational Medicine<\/em>. The blood-brain barrier usually keeps drugs and other compounds from entering the brain in large enough quantities to be effective, but these studies show a way to trick the body&rsquo;s own defenses into letting the drug in, demonstrating that this obstacle to treating Alzheimer&rsquo;s could potentially be overcome.<\/p><p><strong>How the Heck:<\/strong><\/p><p> Antibodies&mdash;immune proteins that attack disease-causers like viruses and bacteria&mdash;are far too big to fit through the <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/en.wikipedia.org\/wiki\/Blood-brain_barrier\">blood-brain barrier<\/a> under normal circumstances. But because of the brain&rsquo;s need for iron, one protein is routinely ferried across the barrier: <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/en.wikipedia.org\/wiki\/Transferrin\">transferrin<\/a>, which binds to iron in the blood.<br>So, the researchers added a molecular structure to the antibody that essentially fooled receptors in the blood-brain barrier into treating the antibody as though it were transferrin, picking it up from the bloodstream and <a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/news.sciencemag.org\/sciencenow\/2011\/05\/tricking-the-brain-into-taking-i.html\">releasing it on the other side<\/a>, into the brain. Ten times as much of the modified antibody made it past the barrier, compared to a version of ...<\/p><p><a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/feedads.g.doubleclick.net\/~a\/Qesa2v1lp61bX2IbiT3smTd4WX8\/0\/da\"><img decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/194f6_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><br><a rel=\"nofollow\" target=\"_blank\" href=\"http:\/\/feedads.g.doubleclick.net\/~a\/Qesa2v1lp61bX2IbiT3smTd4WX8\/1\/da\"><img decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/194f6_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><\/p><p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/194f6_fHgxMSo3Q80\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/wp-content\/plugins\/wp-o-matic\/cache\/194f6_FLvGqmok_2A\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><\/p>","protected":false},"excerpt":{"rendered":"<p>What&rsquo;s the News: A modified antibody can make its way into the brain and target the development of Alzheimer&rsquo;s-inducing plaques, researchers reported today in two animal studies in Science Translational Medicine. The blood-brain barrier usually keeps drugs and other compounds &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/astronomy\/new-way-to-smuggle-drugs-into-brain-may-lead-to-better-alzheimer%e2%80%99s-treatments-80beats.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[21],"tags":[],"class_list":["post-35730","post","type-post","status-publish","format-standard","hentry","category-astronomy"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/35730"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=35730"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/35730\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=35730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=35730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=35730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}