{"id":28712,"date":"2010-10-11T17:14:47","date_gmt":"2010-10-11T17:14:47","guid":{"rendered":"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/kif-6-genetic-findings-useful-medicine-1-in-1000-times\/"},"modified":"2010-10-11T17:14:47","modified_gmt":"2010-10-11T17:14:47","slug":"kif-6-genetic-findings-useful-medicine-1-in-1000-times","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/genetic-medicine\/kif-6-genetic-findings-useful-medicine-1-in-1000-times.php","title":{"rendered":"Kif 6, Genetic Findings = Useful Medicine 1 in 1000 times"},"content":{"rendered":"

\"\"<\/a><\/p>

Way back in <\/span>2008 I mentioned an article<\/span><\/a>, which I hoped would pan out. Or at least I hoped it would point the way to a model of PGx<\/span> research which would be followed by pharma<\/span> and alike to find associations to help us target the right medication for the right patient.<\/span><\/div>

<\/p>

While the similar model followed through with Plavix<\/span>,<\/span> the initial study did not. <\/span><\/a><\/div>

<\/p>

Which is why when the Berkeley Heart Lab guy came last week, I told him I would not be testing for Kif<\/span>6. <\/span>It had not been replicated in further GWAS<\/span>.<\/span><\/a><\/div>
Heck, <\/span>I don't even use the 9p21.3 test......Why?<\/span><\/a><\/div>

<\/p>

A VAP<\/span> cholesterol panel, a HsCRP<\/span>, a family history and a blood pressure can help me predict risk much better.<\/span><\/div>

<\/p>

The problem and backlash facing DTCG<\/span> and DTMD<\/span> genetic test purveyors is <\/span><\/div>

<\/p>

the 'Ol<\/span> \"Your million dollar major study now rushed to market has just been refuted\"<\/span><\/div>

<\/p>

Yes this happens in biomedical science and in medicine ALL THE TIME.<\/span><\/div>
Bed rest for MI anyone?<\/span><\/div>
Low Dose Dopamine?<\/span><\/div>
I could go on and on, but I won't<\/span><\/div>

<\/p>

Put simply, the majority of the genome is NOT ready for clinical medicine or clinical decision making.<\/span><\/div>

<\/p>

It won't be for 20 years.<\/span><\/div>

<\/p>

That doesn't mean there aren't some things we can use.<\/span><\/div>

<\/p>

1. BRCA<\/span>1\/2<\/span><\/div>
2. MMR<\/span> genes<\/span><\/div>
3. CYP<\/span>2C19<\/span><\/div>
4. CYP<\/span>2D6, sometimes.....<\/span><\/div>
5. SCD<\/span> genes<\/span><\/div>
6. Counsyl<\/span> universal carrier screening<\/span><\/div>

<\/p>

That is why the FDA is all hepped<\/span> up about DTCG<\/span> and even DTMD<\/span>.<\/a><\/span><\/div>

<\/p>

If a gene test comes to market that purports disease risk it had better be studied for at least 5 years before it comes to market.<\/span><\/div>

<\/p>

Post market surveillance did not protect all those patients on Statins<\/span>, \"just because\" of Kif<\/span>6 risk.<\/span><\/div>

<\/p>

Get it? These tests can lead to incorrect medical decisions....
<\/span><\/div>
Which can lead to risk.
<\/span><\/div>
Yes, even the DTCG<\/span> tests can fool doctors and patients.
<\/span><\/div>
<\/span><\/div>

The Sherpa Says: If 2008 was the year of the GWAS<\/span>, will 2011 be the year of the overturned GWAS<\/span>?<\/span><\/strong><\/p>

\"\"<\/div>","protected":false},"excerpt":{"rendered":"

Way back in 2008 I mentioned an article, which I hoped would pan out. Or at least I hoped it would point the way to a model of PGx research which would be followed by pharma and alike to find … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-28712","post","type-post","status-publish","format-standard","hentry","category-genetic-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/28712"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=28712"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/28712\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=28712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=28712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=28712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}