{"id":26466,"date":"2010-07-29T13:29:36","date_gmt":"2010-07-29T13:29:36","guid":{"rendered":"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/another-ho-hum-for-snps-fgfr2-and-breast-cancer-risk\/"},"modified":"2010-07-29T13:29:36","modified_gmt":"2010-07-29T13:29:36","slug":"another-ho-hum-for-snps-fgfr2-and-breast-cancer-risk","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/genetic-medicine\/another-ho-hum-for-snps-fgfr2-and-breast-cancer-risk.php","title":{"rendered":"Another Ho Hum for SNPs, FGFR2 and breast cancer risk."},"content":{"rendered":"

The setting: <\/span>Salvage of SNPs<\/span> for Breast Cancer risk prediction<\/a> published in JAMA<\/span> yesterday.<\/span><\/p>

The study: Women, 10306 with breast cancer mean age of Dx<\/span> 58, 10393 sans breast cancer.<\/span><\/p>

Outcomes: <\/span>
1. Highest OR is 1.3 to predict Estrogen Receptor (ER) Positive vs ER negative with rs2981582 and 1.24 for rs3803662<\/span>
2. The rest of the results were so suspect that the authors didn't include them in the abstract<\/span><\/p>

\"Certain Established risk factors for breast cancer have similar or even greater effects on breast cancer incidence that the differences seen here\" -The Authors about this study's<\/span> predictive model.<\/span><\/p>

Bottom line: What good is a predictive SNP<\/span> analysis of ER+ vs ER- if you can do that with pathology most of the time?<\/span><\/p>

\"Indeed or estimate of.....in the top fifth for polygenic<\/span> risk score is similar to that for women in developed countries with one first degree relative with breast cancer\" -The Authors about the less than useful polygenic<\/span> risk model they created when compared to family history<\/span><\/p>

Heck even the authors admit, this stuff is great......For studying pathogenesis, but NOT FOR CLINICAL USE TO GUIDE PREVENTION PROGRAMS!!!<\/span><\/p>

The Sherpa Says: Again, \"You would be in the high risk of pretty much getting it\".........Not a good way to do medicine or guide consumers guys.....<\/a><\/span><\/p>

\"\"<\/div>","protected":false},"excerpt":{"rendered":"

The setting: Salvage of SNPs for Breast Cancer risk prediction published in JAMA yesterday.The study: Women, 10306 with breast cancer mean age of Dx 58, 10393 sans breast cancer.Outcomes: 1. Highest OR is 1.3 to predict Estrogen Receptor (ER) Positive … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-26466","post","type-post","status-publish","format-standard","hentry","category-genetic-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/26466"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=26466"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/26466\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=26466"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=26466"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=26466"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}