Among the many mysteries of human biology is why complex diseases such as diabetes, high blood pressure and psychiatric disorders are so difficult to predict and, often, to treat. An equally perplexing puzzle is why one individual gets a disease such as cancer or depression, while an identical twin remains perfectly healthy. <\/p>\n
Now scientists have discovered a vital clue to unraveling these riddles. <\/p>\n
The human genome is packed with at least 4 million gene switches that reside in bits of DNA that once were dismissed as junk but that turn out to play critical roles in controlling how cells, organs and other tissues behave. <\/p>\n
The discovery, considered a major medical and scientific breakthrough, has enormous implications for human health because many complex diseases appear to be caused by tiny changes in hundreds of gene switches. <\/p>\n
The findings are the fruit of an immense federal project, involving 440 scientists from 32 labs around the world. <\/p>\n
As they delved into the junk parts of the DNA that are not actual genes containing instructions for proteins they discovered it's not junk at all. At least 80 percent of it is active and needed. <\/p>\n
The result is an annotated road map of much of this DNA, noting what it's doing and how. <\/p>\n
It includes the system of switches that, acting like dimmer switches for lights, control which genes are used in a cell and when they are used, and determine, for instance, whether a cell becomes a liver cell or a neuron. <\/p>\n
The findings have immediate applications for understanding how alterations in the nongene parts of DNA contribute to human diseases, which may in turn lead to new drugs. <\/p>\n
They also can help explain how the environment can affect disease risk. <\/p>\n<\/p>\n
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\nDNA \u2018junk' contains a treasure of information about disease<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"