Public release date: 28-Mar-2013 [ | E-mail | Share ] <\/p>\n
Contact: Jim Fessenden james.fessenden@umassmed.edu<\/a> 508-856-2000 University of Massachusetts Medical School<\/p>\n WORCESTER, MA Sometimes you just can't resist a tiny piece of chocolate cake. Even the most health-conscious eaters find themselves indulging in junk foods from time to time. New research by scientists at the University of Massachusetts Medical School (UMMS) raises the striking possibility that even small amounts of these occasional indulgences may produce significant changes in gene expression that could negatively impact physiology and health. <\/p>\n A pair of papers published in Cell by A.J. Marian Walhout, PhD, co-director of the Program in Systems Biology and professor of molecular medicine at UMMS, describe how metabolism and physiology are connected to diet. Using C. elegans, a transparent roundworm often used as a model organism in genetic studies, Dr. Walhout and colleagues observed how different diets produce differences in gene expression in the worm that can then be linked to crucial physiological changes. <\/p>\n \"In short, we found that when C. elegans are fed diets of different types of bacteria, they respond by dramatically changing their gene expression program, leading to important changes in physiology,\" said Walhout. \"Worms fed a natural diet of Comamonas bacteria have fewer offspring, live shorter and develop faster compared to worms fed the standard laboratory diet of E. coli bacteria.\" <\/p>\n Walhout and colleagues identified at least 87 changes in C. elegans gene expression between the two diets. Surprisingly, these changes were independent of the TOR and insulin signaling pathways, gene expression programs typically active in nutritional control. Instead, the changes occur, at least in part, in a regulator that controls molting, a gene program that determines development and growth in the worm. This connection provided one of the critical links between diet, gene expression and physiology detailed in \"Diet-induced Development Acceleration Independent of TOR and Insulin in C. elegans.\" \"Importantly, these same regulators that are influenced by diet in the worms control circadian rhythm in humans,\" said Lesley MacNeil, PhD, a postdoctoral student in the Walhout Lab and first author on the paper. \"We already know that circadian rhythms are affected by diet. This points to the real possibility that we can now use C. elegans to study the complex connections between diet, gene expression and physiology and their relation to human disease.\" <\/p>\n Strikingly, Walhout and colleagues observed that even when fed a small amount of the Comamonas bacteria in a diet otherwise comprised of E. coli bacteria, C. elegans exhibited dramatic changes in gene expression and physiology. These results provide the tantalizing possibility that different diets are not \"healthy\" or \"unhealthy\" but that specific quantities of certain foods may be optimal under different conditions and for promoting different physiological outcomes. <\/p>\n \"It's just as true that a small amount of a 'healthy' food in an otherwise unhealthy diet could elicit a beneficial change in gene expression that could have profound physiological effects,\" said Walhout. <\/p>\n Additional research by the Walhout Lab further explored the possibility of using C. elegans as a model system to answer complex questions about disease and dietary treatment in humans. Detailed in the \"Integration of Metabolic and Gene Regulatory Networks Modulates the C. elegans Dietary Response,\" Walhout and colleagues found that disrupting gene expression involved with C. elegans metabolism lead to metabolic imbalances that interfered with the animal's dietary response; a result that may have a direct correlation to the treatment of a class of human genetic diseases. <\/p>\n \"To better understand the molecular mechanisms by which diet effects gene expression in the worm, we performed complimentary genetic screens looking for genes that gave an abnormal response to diet,\" said Emma Watson, a doctoral student in the Walhout Lab and co-first author on the second Cell study together with Dr. MacNeil. \"What we discovered was a large network of metabolic and regulator genes that can integrate internal cellular nutritional needs and imbalances with external availability,\" said Watson. \"This information is then communicated to information processing genes in the worm to illicit the appropriate response in the animal.\" <\/p>\n <\/p>\n See original here: Public release date: 28-Mar-2013 [ | E-mail | Share ] Contact: Jim Fessenden james.fessenden@umassmed.edu<\/a> 508-856-2000 University of Massachusetts Medical School WORCESTER, MA Sometimes you just can't resist a tiny piece of chocolate cake. Even the most health-conscious eaters find themselves indulging in junk foods from time to time. Continue reading
\nUMMS scientists tie dietary influences to changes in gene expression and physiology<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"