Regular use of vitamin and mineral supplements could help to reduce the risk of colon cancer and protect against carcinogens, according to new research in rats.<\/p>\n
The study \u2013 published in the Canadian Journal of Physiology and Pharmacology (CJPP) \u2013 found that rats given regular multivitamin and mineral supplements showed a significantly lower risk of developing colon cancer when they were exposed to carcinogens. <\/p>\n
\u201cMultivitamin and mineral supplements synergistically contribute to the cancer chemopreventive potential, and hence, regular supplements of multivitamins and minerals could reduce the risk of colon cancer,\u201d explained the authors, led by Dr Ignacimuthu Savarimuthu of Loyola College, India. <\/p>\n
Commenting on the study, Dr. Grant Pierce, Editor of CJPP said: \"It has been unclear whether multivitamin supplementation to cancer patients is helpful, has no effect, or is even detrimental during therapy,\" <\/p>\n
Cancer nutrition <\/p>\n
Dietary nutrients \u201care well documented to be chemopreventive in the epidemiology of colon cancer,\u201d said the authors, noting that there has been \u2018considerable\u2019 interest in establishing the role of particular nutrients, either individually or in combination, to prevent colon cancer.
\u201cResearch on multivitamin and mineral supplementation from diet and cancer are often speculative\u201d, said the research team. However there have been several epidemiological studies in recent years that have linked dietary nutrients to colon cancer risk \u2013 including one reporting a \u2018strong association\u2019 with vitamins A, C, and E , and other studies linking vitamin B and vitamin D status to risk of the cancer.
\u201cAlthough the specific dietary factors responsible for this protective effect have not been clearly identified, [it is clear that] fruits and vegetables contain vitamins and minerals that may influence cancer,\u201d said the researchers <\/p>\n
\u201cThe objective of this study was to show that including vitamin and mineral supplements in a regular diet could reduce cancer risk and protect against carcinogenesis,\u201d they explained. <\/p>\n
Study details <\/p>\n
Ignacimuthu and colleagues split rats into 6 groups, which were then exposed to different combinations of supplements and carcinogens (1,2-dimethylhydrazine) \u2013 DMH-induced rat colon carcinogenesis is one of the most widely studied experimental models in cancer chemoprevention studies. The authors added that all rats were fed a high-fat diet (20% fat) over the 32 week study period. <\/p>\n
They revealed that rats fed a high-fat plus low-fibre diet and exposed to carcinogens developed pre-cancerous lesions; whereas, rats undergoing similar treatment, but provided with daily multivitamin and mineral supplements, showed an 84% reduction in the formation such of pre-cancerous lesions, and did not develop tumours. <\/p>\n
\u201cMultivitamin and mineral supplementation during the initiation, post-initiation, and the entire study period significantly decreased the levels of lipid peroxidation products in circulation and colonic tissues, significantly elevated the activities of the antioxidant enzymes and reduced glutathione to near normalcy in DMH-induced rats,\u201d wrote the authors. <\/p>\n
Source: Canadian Journal of Physiology and Pharmacology
Volume 90, Issue 1, Pages 45-54, doi: 10.1139\/y11-100
\u201cMultivitamin and mineral supplementation in 1,2-dimethylhydrazine induced experimental colon carcinogenesis and evaluation of free radical status, antioxidant potential, and incidence of ACF\u201d
Authors: A.B. Arul, I. Savarimuthu, M.A. Alsaif, K.S. Al Numair <\/p>\n<\/p>\n
Follow this link: Regular use of vitamin and mineral supplements could help to reduce the risk of colon cancer and protect against carcinogens, according to new research in rats. The study \u2013 published in the Canadian Journal of Physiology and Pharmacology (CJPP) \u2013 found that rats given regular multivitamin and mineral supplements showed a significantly lower risk of developing colon cancer when they were exposed to carcinogens. Continue reading
\nVitamin and mineral supplements may reduce colon cancer risk: Rat study<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"