Newswise \u2014 Pediatric and Developmental Pathology \u2013 Gonadal dysgenesis\u2014defective development of the ovaries or testes\u2014 may also bring with it an increased risk of gonadal tumors. A recent discovery at the histologic level could help identify cells at risk of conversion into a tumor. For patients with XY gonadal dysgenesis, this means earlier detection and treatment of tumors. <\/p>\n
A study in the current issue of the journal Pediatric and Developmental Pathology retrospectively examined gonads from 30 patients with gonadal dysgenesis. Cytogenic analyses were performed, investigating specifically the role of a primitive tissue known as \u201cundifferentiated gonadal tissue.\u201d <\/p>\n
The complex processes of sexual development and differentiation into male or female can be disrupted in many ways. Pure, or complete, gonadal dysgenesis and mixed gonadal dysgenesis are among the most frequently occurring of these disorders. X\/XY gonadal mosaicism, has been shown to play a role in disorders of sexual differentiation. <\/p>\n
Undifferentiated gonadal tissue describes the presence of persistent primitive sex cords containing immature germ cells. These immature germ cells represent a risk factor for gonadal tumors. They hold the possibility of neoplastic transformation into a tumor. <\/p>\n
The authors advise that germ cells in gonadal streaks should not be overlooked. Of 13 gonads in this study that were found to have both undifferentiated gonadal tissue and a streak, 9 developed a tumor. <\/p>\n
About 30 percent of patients with pure gonadal dysgenesis, and 15 percent with mixed gonadal dysgenesis go on to develop gonadal tumors. These are mostly ganodoblastomas, which are benign, but in 60 percent of these cases, the patients may develop malignant tumors. Finding the etiology of these neoplasms is an essential step in stopping their development. <\/p>\n
Full text of the article, \u201cUndifferentiated Gonadal Tissue, Y Chromosome Instability, and Tumors in XY Gonadal Dysgenesis,\u201d Pediatric and Developmental Pathology, Vol. 14, No. 6, 2011, is available at http:\/\/www.pedpath.org\/toc\/pdpa\/14\/6<\/a>. <\/p>\n Comment\/Share Read the rest here: Newswise \u2014 Pediatric and Developmental Pathology \u2013 Gonadal dysgenesis\u2014defective development of the ovaries or testes\u2014 may also bring with it an increased risk of gonadal tumors. A recent discovery at the histologic level could help identify cells at risk of conversion into a tumor. For patients with XY gonadal dysgenesis, this means earlier detection and treatment of tumors Continue reading
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\nNew Pattern Identifies Cells That Pose Risk of Tumors in Gonadal Dysgenesis Patients<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"