{"id":245337,"date":"2011-01-09T18:12:39","date_gmt":"2011-01-09T18:12:39","guid":{"rendered":"http:\/\/eugenesis.com\/tissue-based-proteomics-meets-digital-pathology\/"},"modified":"2011-01-09T18:12:39","modified_gmt":"2011-01-09T18:12:39","slug":"tissue-based-proteomics-meets-digital-pathology","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/pathology\/tissue-based-proteomics-meets-digital-pathology.php","title":{"rendered":"Tissue-based proteomics meets digital pathology"},"content":{"rendered":"<div><p>Expression Pathology and Flagship Biosciences recently announced a services alliance in <a href=\"http:\/\/www.flagshipbio.com\/news\/december-9-2010\/\" target=\"_self\">tissue-based proteomics<\/a>, combining digital pathology with mass-spec FFPE tissue proteomics. While this collaboration is oriented towards research and <a href=\"http:\/\/www.flagshipbio.com\/services-2\/tissue-biomarker-development\/\" target=\"_self\">companion diagnostics<\/a>&nbsp;development, mass spec is making rapid inroads in all areas of clinical applications, including tissue. The ability to run protein expression in FFPE instead of fresh tissue is a major enhancement on the road to clinical adoption. Mass spec offers the ability to better characterize post-translational modifications of proteins and various isoforms, high levels of multiplexing, and the avoidance of dependence on a given target epitope or antibody for test results. It does require up to 30,000 cells for protein expression measurements, meaning approximately 2 mm x 4 mm of 10 micron thick tissue sample. Up until now, one of the most manual steps has been the selection of tissue for the microdissection, an obvious application where <a href=\"http:\/\/www.tissuepathology.com\/weblog\/www.flagshipbio.com\" target=\"_self\">digital pathology<\/a> and <a href=\"http:\/\/www.flagshipbio.com\/uncategorized\/histology-pattern-recognition-zoom-out\/\" target=\"_self\">histology pattern recognition<\/a> can have advantages. The Mayo Clinic licenses Expression Pathology's approach in the&nbsp;<a href=\"http:\/\/www.expressionpathology.com\/pdf\/Mayo_EPI_License_Nov_17_09.pdf\" target=\"_self\">diagnosis and classification of amyloidosis<\/a> in routine&nbsp;biopsy specimen. A number of large reference laboratories are systematically transitioning their small molecular analysis platforms from the traditional ELISAs that require antibodies to mass spec.&nbsp;<\/p><\/div><div><a href=\"http:\/\/feeds.feedburner.com\/~ff\/DigitalPathologyBlog?a=2QmApKAC0qI:P_GU_IA4d-4:yIl2AUoC8zA\"><img decoding=\"async\" src=\"http:\/\/eugenesis.com\/wp-content\/plugins\/wp-o-matic\/cache\/7c9fb_DigitalPathologyBlog?d=yIl2AUoC8zA\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/DigitalPathologyBlog?a=2QmApKAC0qI:P_GU_IA4d-4:F7zBnMyn0Lo\"><img decoding=\"async\" src=\"http:\/\/eugenesis.com\/wp-content\/plugins\/wp-o-matic\/cache\/7c9fb_DigitalPathologyBlog?i=2QmApKAC0qI:P_GU_IA4d-4:F7zBnMyn0Lo\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/DigitalPathologyBlog?a=2QmApKAC0qI:P_GU_IA4d-4:7Q72WNTAKBA\"><img decoding=\"async\" src=\"http:\/\/eugenesis.com\/wp-content\/plugins\/wp-o-matic\/cache\/7c9fb_DigitalPathologyBlog?d=7Q72WNTAKBA\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/DigitalPathologyBlog?a=2QmApKAC0qI:P_GU_IA4d-4:V_sGLiPBpWU\"><img decoding=\"async\" src=\"http:\/\/eugenesis.com\/wp-content\/plugins\/wp-o-matic\/cache\/7c9fb_DigitalPathologyBlog?i=2QmApKAC0qI:P_GU_IA4d-4:V_sGLiPBpWU\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/DigitalPathologyBlog?a=2QmApKAC0qI:P_GU_IA4d-4:qj6IDK7rITs\"><img decoding=\"async\" src=\"http:\/\/eugenesis.com\/wp-content\/plugins\/wp-o-matic\/cache\/7c9fb_DigitalPathologyBlog?d=qj6IDK7rITs\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/DigitalPathologyBlog?a=2QmApKAC0qI:P_GU_IA4d-4:l6gmwiTKsz0\"><img decoding=\"async\" src=\"http:\/\/eugenesis.com\/wp-content\/plugins\/wp-o-matic\/cache\/7c9fb_DigitalPathologyBlog?d=l6gmwiTKsz0\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/DigitalPathologyBlog?a=2QmApKAC0qI:P_GU_IA4d-4:gIN9vFwOqvQ\"><img decoding=\"async\" src=\"http:\/\/eugenesis.com\/wp-content\/plugins\/wp-o-matic\/cache\/7c9fb_DigitalPathologyBlog?i=2QmApKAC0qI:P_GU_IA4d-4:gIN9vFwOqvQ\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a> <a href=\"http:\/\/feeds.feedburner.com\/~ff\/DigitalPathologyBlog?a=2QmApKAC0qI:P_GU_IA4d-4:TzevzKxY174\"><img decoding=\"async\" src=\"http:\/\/eugenesis.com\/wp-content\/plugins\/wp-o-matic\/cache\/535df_DigitalPathologyBlog?d=TzevzKxY174\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><\/div><p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/eugenesis.com\/wp-content\/plugins\/wp-o-matic\/cache\/535df_2QmApKAC0qI\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Expression Pathology and Flagship Biosciences recently announced a services alliance in tissue-based proteomics, combining digital pathology with mass-spec FFPE tissue proteomics. While this collaboration is oriented towards research and companion diagnostics&nbsp;development, mass spec is making rapid inroads in all areas &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/pathology\/tissue-based-proteomics-meets-digital-pathology.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":57,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[577487],"tags":[],"class_list":["post-245337","post","type-post","status-publish","format-standard","hentry","category-pathology"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/245337"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/57"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=245337"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/245337\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=245337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=245337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=245337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}