Public release date: 31-May-2012 [ | E-mail | Share ] <\/p>\n
Contact: Abby Robinson abby@innovate.gatech.edu<\/a> 404-385-3364 Georgia Institute of Technology Research News<\/p>\n On the periodic table of the elements, iron and magnesium are far apart. But new evidence suggests that 3 billion years ago, iron did the chemical work now done by magnesium in helping RNA fold and function properly. <\/p>\n There is considerable evidence that the evolution of life passed through an early stage when RNA played a more central role before DNA and coded proteins appeared. During that time, more than 3 billion years ago, the environment lacked oxygen but had an abundance of soluble iron. <\/p>\n In a new study, researchers from the Georgia Institute of Technology used experiments and numerical calculations to show that iron, in the absence of oxygen, can substitute for magnesium in RNA binding, folding and catalysis. The researchers found that RNA's shape and folding structure remained the same and its functional activity increased when magnesium was replaced by iron in an oxygen-free environment. <\/p>\n \"The primary motivation of this work was to understand RNA in plausible early earth conditions and we found that iron could support an array of RNA structures and catalytic functions more diverse than RNA with magnesium,\" said Loren Williams, a professor in the School of Chemistry and Biochemistry at Georgia Tech. <\/p>\n The results of the study were published online on May 31, 2012 in the journal PLoS ONE. The study was supported by the NASA Astrobiology Institute. <\/p>\n In addition to Williams, Georgia Tech School of Biology postdoctoral fellow Shreyas Athavale, research scientist Anton Petrov, and professors Roger Wartell and Stephen Harvey, and Georgia Tech School of Chemistry and Biochemistry postdoctoral fellow Chiaolong Hsiao and professor Nicholas Hud also contributed to this work. <\/p>\n Free oxygen gas was almost nonexistent more than 3 billion years ago in the early earth's atmosphere. When oxygen began entering the environment as a product of photosynthesis, it turned the earth's iron to rust, forming massive banded iron formations that are still mined today. The free oxygen produced by advanced organisms caused iron to be toxic, even though it was -- and still is -- a requirement for life. <\/p>\n This environmental transition triggered by the introduction of free oxygen into the atmosphere would have caused a slow, but dramatic, shift in biology that required transformations in biochemical mechanisms and metabolic pathways. The current study provides evidence that this transition may have caused a shift from iron to magnesium for RNA binding, folding and catalysis processes. <\/p>\n<\/p>\n Read more: Public release date: 31-May-2012 [ | E-mail | Share ] Contact: Abby Robinson abby@innovate.gatech.edu<\/a> 404-385-3364 Georgia Institute of Technology Research News On the periodic table of the elements, iron and magnesium are far apart. Continue reading
\nOn early Earth, iron may have performed magnesium's RNA folding job<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"