New research suggests that microRNAs may be the key to downregulating PD-L1 and improving immunotherapy treatment for malignant mesothelioma. <\/p>\n
Raleigh, NC (PRWEB) June 25, 2017 <\/p>\n
Australian researchers studying the protein PD-L1 have developed a way to potentially turn off the mechanism that lets mesothelioma tumors hide from the immune system. Surviving Mesothelioma has the full story. Click here to read it now. <\/p>\n
Doctors at the Asbestos DIseases Research Institute at the University of Sydney found key differences in the action of certain microRNAs among mesothelioma patients with elevated levels of PD-L1. <\/p>\n
\"In the same patient series, PD-L1 expression was also associated with downregulation of microRNAs previously shown to have tumour suppressor activity in malignant pleural mesothelioma,\" writes Steven C. Kao, the lead author on the paper. <\/p>\n
According to the study in the Journal of Thoracic Oncology, the researchers determined that it is possible to downregulate PD-L1 expression by inserting \"mimic\" microRNAs into mesothelioma cells in the lab. <\/p>\n
\"This is especially noteworthy since mesothelioma patients who test positive for PD-L1 overexpression are more likely to have a non-epithelioid type of mesothelioma and poorer odds of survival,\" says Alex Strauss, Managing Editor for Surviving Mesothelioma. <\/p>\n
For the details of the new clinical trial and more about PD-L1 and microRNAs in mesothelioma, see MicroRNAs May Be Key to Better Immunotherapy for Mesothelioma, now available on the Surviving Mesothelioma website. <\/p>\n
Kao, SC, et al, \"Tumour suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma\", June 16, 2017, Journal of Thoracic Oncology, Epub ahead of print, http:\/\/www.jto.org\/article\/S1556-0864(17)30460-4\/fulltext<\/a> <\/p>\n For more than a decade, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions. <\/p>\n For the original version on PRWeb visit: http:\/\/www.prweb.com\/releases\/2017\/06\/prweb14458786.htm<\/a> <\/p>\n<\/p>\n <\/p>\n Continue reading here: <\/p>\n Scientists "Turn Off" Tumor-Protecting Protein in New Mesothelioma Study, According to Surviving Mesothelioma - Benzinga<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" New research suggests that microRNAs may be the key to downregulating PD-L1 and improving immunotherapy treatment for malignant mesothelioma. Raleigh, NC (PRWEB) June 25, 2017 Australian researchers studying the protein PD-L1 have developed a way to potentially turn off the mechanism that lets mesothelioma tumors hide from the immune system. Surviving Mesothelioma has the full story. Continue reading