{"id":21132,"date":"2010-06-16T08:08:46","date_gmt":"2010-06-16T08:08:46","guid":{"rendered":"http:\/\/euvolution.com\/futurist-transhuman-news-blog\/ok-spam-botted-prasugrel-plus-2c19-pm-has-better-outcome\/"},"modified":"2010-06-16T08:08:46","modified_gmt":"2010-06-16T08:08:46","slug":"ok-spam-botted-prasugrel-plus-2c19-pm-has-better-outcome","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/genetic-medicine\/ok-spam-botted-prasugrel-plus-2c19-pm-has-better-outcome.php","title":{"rendered":"Ok, Spam Botted! Prasugrel PLUS 2C19 PM has better outcome."},"content":{"rendered":"

\"\"<\/a>
Alright, so I just found out that I posted a spam bot post. Not from a nice student named Ashley.<\/span><\/p>

Instead what I will post is a subgroup analysis of <\/span>TRITON TIMI 38. <\/a> The subgroup analysis? 2C19 PMs and Prasugrel.<\/a><\/p>

Great clinical question-Did the PMs (poor metabolizers) on Prasugrel fare better than the PMs on Plavix.<\/span> <\/span><\/p>

The obvious answer:
Duh, of course yes.<\/p>

But Always we need some science and statistics here. <\/span><\/p>

Individuals with a CYP2C19 reduced-metabolizer genotype were estimated to have a substantial reduction in the risk of the composite primary outcome (cardiovascular death, myocardial infarction or stroke) with prasugrel compared to clopidogrel (relative risk 0.57; 95% confidence interval [CI], 0.39 to 0.83).<\/p>

Ok, so we should screen for PMs? Probably.<\/span><\/p>

What about every other result?<\/p>

What about the EMs?<\/p>

For CYP2C19 extensive-metabolizers (EM) ( approximately 70% of the population), however, the composite outcome risks with prasugrel and clopidogrel were not substantially different (relative risk 0.98; 95% CI, 0.80 to 1.20).<\/span> <\/span><\/p>

The Sherpa Says: We should AT LEAST be identifying the PMs and placing them on Prasugrel. This subgroup analysis shows increased risk while on Plavix. Primum Non Nocere.<\/span><\/p>

\"\"<\/div>","protected":false},"excerpt":{"rendered":"

Alright, so I just found out that I posted a spam bot post. Not from a nice student named Ashley.Instead what I will post is a subgroup analysis of TRITON TIMI 38. The subgroup analysis? 2C19 PMs and Prasugrel.Great clinical … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-21132","post","type-post","status-publish","format-standard","hentry","category-genetic-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/21132"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=21132"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/21132\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=21132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=21132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=21132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}