Human mesenchymal stem cells (Image: Rose Spear\/Flickr) <\/p>\n
New gene editing methods like CRISPR\/Cas9 have given scientists unprecedented potential to edit human DNA. But how should researchers in the field actually use these methods, especially when editing traits that can be passed down to children? Should they be used to cure disease? Should they be used to enhance features that arent necessary for our survival?<\/p>\n
Were definitely far from seeing X-men mutants and genetically modified superhumans from whatever dystopian young adult novel you may be reading, especially in the United States where lawmakers passed legislation preventing government money from funding this kind of research. That hasnt stopped researchers in other countries like China from creating gene-edited embryos, which has some scientists very concerned. Today, the National Academies of Sciences and Medicine released a major new report and recommendations to ensure any such research done stateside in the future is performed responsibly and ethically. <\/p>\n
The implicit message is that whether we like it or not, a future of gene-edited humans is on its way. <\/p>\n
Although scientists have been able to chop up DNA for decades, precise new tools like CRISPR\/Cas9 make it easier than ever to experiment with gene-edited livestock, or using gene-edited cells to help fight cancer in humans, for instance. But CRISPRs relative ease of use has caused many to worry about the ethical implications of germline editing, or editing traits in cells that could be passed on to later generations. A commentary published in 2015 in Nature warns that gene editing humans could have unpredictable effects on future generations. <\/p>\n
The new National Academies report is an attempt to offer guidance both for germline editing to cure disease, as well as for enhancementmaking stronger, smarter, better humansshould the funding ban in the United States lift. <\/p>\n
The Academies ruling on germline editing for curing inherited diseases is basically that scientists need to be very careful. The group recommends only permitting such procedures with lots of oversight, so long as researchers dont have better treatment options, know for a fact the gene theyre editing causes disease, are editing the gene to match the naturally-occurring healthy version, and perform rigorous research including clinical trials and multi-generational follow-up studies. After all, they need to ensure they havent accidentally introduced some dangerous mutation that will harm future humans. <\/p>\n
As far as editing germline cells for human enhancement, the Academies said no wayat least, not yet. They hope to see further public discussion to make sure people are okay with what we might be doing to our species. I think its basically a lets buy some time, director of New York Universitys Division of Medical Ethics Arthur Caplan told Gizmodo. Its not inappropriate to buy some time. The techniques are new and we dont know if theyre safe. Plus, the technology isnt even close to making superbabies, although that hasnt stopped ethicists from considering the moral conundrum superbabies pose. <\/p>\n
Caplan was concerned that the report didnt more strongly recommend testing any potential gene editing procedures in animals first, or discuss who actually owns the rights to various gene editing methods and how much they will cost. Im very worried about access, he said. Whos keeping an eye on the prices that will be charged? Will this be another repeat of the drug price problems? <\/p>\n
Ultimately, the Academies and Caplan hope to see more communication between the scientists and the public about how we as a society feel about gene editing. The reality is the scientific community hasnt really spent enough resources thinking about how to really engage the public, said Caplan. They have to do more surveys, better outreach, use the internet more. The report is quiet about that...Weve gotta get more creative than weve been. <\/p>\n
Update 1:55PM: Some are disappointed with the Academies statement, which approves of genetic engineering despite the cautious wording. The Center for Genetics and Society sent Gizmodo a statement including the following quote: <\/p>\n
The recommendations and conclusions of this report are unsettling and disappointing, said Marcy Darnovsky, PhD, Executive Director of the Center for Genetics and Society. Although theyre couched in apparently cautionary language, they actually constitute a green light for proceeding with efforts to modify the human germlinethat is, to engineer the genes and traits that are passed on to future children and generations. <\/p>\n
In December 2015, the National Academies International Summit on Human Gene Editing concluded with a statement that it would be irresponsible to proceed with human germline modification unless and until a broad societal consensus had been reached. Todays report dispenses with the idea of meaningful public participation in this profoundly consequential decision, Darnovsky said. It calls for `continued public engagement [page 146] with the details, but excludes the public from participation in deciding whether human germline modification is acceptable in the first place. <\/p>\n
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Top Science Organization Cautiously Supports Genetically Engineering Humans - Gizmodo<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" Human mesenchymal stem cells (Image: Rose Spear\/Flickr) New gene editing methods like CRISPR\/Cas9 have given scientists unprecedented potential to edit human DNA. But how should researchers in the field actually use these methods, especially when editing traits that can be passed down to children? Should they be used to cure disease Continue reading