{"id":129346,"date":"2013-05-12T03:05:47","date_gmt":"2013-05-12T07:05:47","guid":{"rendered":"https:\/\/www.immortalitymedicine.tv\/the-klein-donation-text-of-robert-kleins-response-re-stemcells-inc\/"},"modified":"2024-08-17T20:31:04","modified_gmt":"2024-08-18T00:31:04","slug":"the-klein-donation-text-of-robert-kleins-response-re-stemcells-inc-3","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/stem-cell-therapy\/the-klein-donation-text-of-robert-kleins-response-re-stemcells-inc-3.php","title":{"rendered":"The Klein Donation: Text of Robert Klein&#8217;s Response re StemCells, Inc."},"content":{"rendered":"<p>Here is the text of the initial<br>response from <b>Robert Klein<\/b>, chairman of the California stem<br>cell agency until July 2011, to questions from the <b>California Stem Cell Report <\/b>(CSCR)<br>concerning his $21,630 donation to the agency. The questions posed by<br>CSCR on precede the response by Klein. Here is <a href=\"http:\/\/californiastemcellreport.blogspot.mx\/2013\/05\/cash-and-favors-robert-klein-gives.html\">a link to a story <\/a>on<br>the matter.<\/p><div><b><br><\/b><\/div><div>CSCR to Klein:<\/div><blockquote><p>&ldquo;Why did you give the agency the<br>money?<br>&ldquo;Did you place on conditions on its<br>use?<br>&ldquo;Did anyone connected with the agency<br>indicate in advance &nbsp;that your donation would be desired? If so<br>who? Who did you deal with primarily on the donation -- Trounson,<br>Thomas or...?<br>&ldquo;The donation came one month after<br>grant reviewers rejected StemCells Inc.'s Alzheimer's application. Do<br>you think it was appropriate to make the donation and then ask the<br>board twice to override its reviewers?<br>&ldquo;Do you think the donation and<br>subsequent action on StemCells, Inc.'s Alzheimer's application will<br>negatively color the perception of future efforts by CIRM at private<br>fundraising?&rdquo;<\/p><\/blockquote><div>Klein's response:<\/div><div><\/div><div>&ldquo;In April or May of 2012 I committed<br>approximately $20,000 as a contribution to CIRM to cover the travel<br>expenses of staff to the International Stem Cell Society<br>meeting in Japan. My commitment to ensure scientific staff can<br>participate in international meetings dates back many years. In 2011<br>I wrote the following explanation of its importance in obtaining the<br>knowledge to accelerate the drive of scientific research to reach<br>patients with chronic disease.<\/div><div>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Leverage<br>Leading Edge Science<\/div><div>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br>&ldquo;Travel by CIRM staff members and leadership permits CIRM to stay<br>in contact with, and understand, the leading edge advances of<br>scientists all over the world, and to leverage those advances by<br>creating a platform for collaborations between these leading<br>scientists and their peers in California. Currently, CIRM has<br>collaboration agreements with 15 foreign governments pursuant to<br>which these governments have pledged $134,380,000 in commitments to<br>fund the work of their scientists on join teams with California<br>scientists to develop therapy candidates and to advance therapies to<br>human trials. Although a significant amount of this commitment is<br>currently pending scientific peer review and not all of it will be<br>awarded as part of a successful application,&nbsp;every dollar in<br>funding by a foreign government magnifies the scientific impact of<br>California&rsquo;s taxpayer dollars. If just $40 million is awarded each<br>year over ten years, it would provide California with $400 million of<br>scientific leverage.<\/div><div><ul><li>&nbsp; &nbsp; It<br>is critical to understand that there are unpublished&nbsp;scientific<br>discoveries in progress in each of these nations. Often, publication<br>may trail a scientific discovery by nine months or more.<\/li><li>&nbsp;&nbsp; &nbsp;The<br>travel requested by CIRM provides a critical link for the timely<br>transmission of valuable new information. California cannot afford to<br>lose the opportunity to harness discoveries in other countries to<br>advance the development of therapies in California and to capture the<br>opportunity to advance therapies for patients instead of using<br>California taxpayer dollars to duplicate discoveries already mastered<br>in other countries.<\/li><li>&nbsp; &nbsp; &nbsp;While<br>CIRM&rsquo;s scientific staff works with scientists in other countries to<br>capture the scientific knowledge for the benefit of California&rsquo;s<br>therapy development teams, the Chairman&rsquo;s Office works with<br>international finance ministers, the premiers of international<br>states, and foreign funding agencies to ensure funding allocations<br>for these bilateral funding agreements. These discussions often<br>involve face-to-face negotiations in foreign nations and states, in<br>addition to meetings at international conferences, all of which are<br>supported by extensive staff work in California.<\/li><li>&nbsp; &nbsp; &nbsp;CIRM<br>issued its first co-funding awards early in 2009. Over the last two<br>years, these agreements have yielded $57 million in international<br>funds actually approved through peer review.&nbsp;This $57 million<br>represents participation by only the first five countries and one<br>international state with which CIRM established a collaboration. Now,<br>CIRM has agreements with nine countries and two international states<br>and an additional three countries will be added in the near future.<\/li><li>&nbsp; &nbsp; Even<br>if CIRM were only to obtain $30 million per year in international<br>matching funds, the ratio of return on CIRM&rsquo;s $206,920 travel<br>expenditures would be approximately 145 to 1.<\/li><li>&nbsp; &nbsp;Proposition 71 specifically anticipated<br>and directs CIRM to develop leverage and global leadership to capture<br>the benefit for patients.<\/li><\/ul><\/div><div>Keeping on the Cutting Edge of Stem<br>Cell Science<\/div><div>\"CIRM&rsquo;s over 20 MDs and\/or PhDs<br>science officers on the grant review staff at CIRM reach out<br>nationally and internationally through conferences that may include<br>10-20 meetings per day and workshops of 8-12 hours per day to grasp<br>the leading edge of this&nbsp;pre-publication,&nbsp;dynamic<br>revolution in medical knowledge.&nbsp;In order to ensure that the<br>every research dollar is optimally deployed to advance therapies to<br>save lives or rescue the quality of life for patients, it is critical<br>that CIRM staff remain on the cutting edge of new discoveries.<br>International conferences and workshops provide a critical<br>opportunity for massive and decisive transfers of information, which<br>ensures that California is funding the right research.<\/div><div>&ldquo;I principally corresponded with Dr.<br>Trounson on the issue covering the travel expenses for the staff for the reasons stated above. I had no input into the selection<br>of scientific staff. In May and even in June when the conference<br>occurred I had no idea that there would be any disagreement on the<b><br><\/b>Alzheimer&rsquo;s application of Stem Cells Inc. in August. At the Board<br>meeting I asked that there be consideration for the fact that three<br>other peer reviews had found the work leading up to this application<br>to be outstanding and they had ranked it highly. In addition, the<br>current peer review had not been briefed on the fact that they<br>downgraded the applicant for following the directions on material<br>points by the prior peer reviews. Finally, the standard deviation on<br>the 2012 peer review was extremely high and the re-review by the<br>three member committee resulted in a split decision. It is<br>particularly appropriate with a huge standard deviation,<br>demonstrating both strong support and opposition within the peer<br>review group, for the Board to make its own independent decision.&nbsp;<br>Please recall that the staff recommended against approval so that<br>they clearly were not influenced by my commitment to a contribution<br>to the Agency, months before, for the benefit of scientific staff to<br>be able to attend an international science conference. Additionally,<br>Dr. Trounson, I believe, recused himself from the review of the Stem<br>Cells Inc. application, for unrelated reasons, so he was not<br>involved. I personally had served on the three prior peer reviews,<br>including one in the prior year that recommended this application for<br>a Disease Team approval. I know how strongly the scientists on those<br>three prior peer reviews supported funding this scientific research,<br>with the 2011 review specifically recommending this Disease Team for<br>approval. I believe it was extremely important for me to provide a<br>voice to those three scientific panels who disagreed with a portion<br>of the scientists on the 2012 scientific panel. Supporting the<br>scientific movement to human trials for Alzheimer&rsquo;s has to be<br>eventually approved by the FDA; but, this loan will move the science<br>and the potential for clinical trials forward significantly and<br>hopefully obtain FDA approval. I believe all three of the Board&rsquo;s<br>overrides of the peer review recommendations on the Disease Team<br>round in 2008 are leading directly to human trials in the United<br>States and\/or United Kingdom. 92% of the all of the funds awarded by<br>CIRM have followed the recommendations of the peer review committee;<br>but, in those significant cases where the Board has made an<br>independent decision, there has been an extremely high success rate<br>particularly when there has been a high level of disagreement within<br>the Peer Review Board that was overridden and prior peer reviews<br>recommended and\/or approved the scientific approach and concepts of<br>the applicant.&rdquo;<p>(Editor's note: &nbsp;The applications in this round were reviewed once in April 2012 by CIRM's full grant review group. StemCells, Inc.'s application was subject to a reevaluation after Klein's appeal in July 2012 and rejected again, but it was not a full review. &nbsp;Klein may be referring also an earlier round that provided grants for planning to apply for the full $20 million.)&nbsp;<\/p><\/div><p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/29e37_57qJcfMUql0\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\">Source:<br><a href=\"http:\/\/feedproxy.google.com\/~r\/blogspot\/uqpFc\/~3\/57qJcfMUql0\/the-klein-donation-text-of-robert_5.html\">http:\/\/feedproxy.google.com\/~r\/blogspot\/uqpFc\/~3\/57qJcfMUql0\/the-klein-donation-text-of-robert_5.html<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Here is the text of the initialresponse from Robert Klein, chairman of the California stemcell agency until July 2011, to questions from the California Stem Cell Report (CSCR)concerning his $21,630 donation to the agency. The questions posed byCSCR on precede &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/stem-cell-therapy\/the-klein-donation-text-of-robert-kleins-response-re-stemcells-inc-3.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[25,1246878],"tags":[],"class_list":["post-129346","post","type-post","status-publish","format-standard","hentry","category-stem-cell-therapy","category-stem-cells"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/129346"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=129346"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/129346\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=129346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=129346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=129346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}