{"id":128964,"date":"2012-07-15T15:50:11","date_gmt":"2012-07-15T15:50:11","guid":{"rendered":"https:\/\/www.immortalitymedicine.tv\/pgc-1alpha-versus-huntingtons-disease\/"},"modified":"2024-08-17T17:05:43","modified_gmt":"2024-08-17T21:05:43","slug":"pgc-1alpha-versus-huntingtons-disease-2","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/pgc-1alpha-versus-huntingtons-disease-2.php","title":{"rendered":"PGC-1alpha Versus Huntington&#8217;s Disease"},"content":{"rendered":"<p>Via <a href=\"http:\/\/www.sciencedaily.com\/releases\/2012\/07\/120711141853.htm\">ScienceDaily<\/a>: researchers \"have identified two key regulatory proteins critical to clearing away misfolded proteins that accumulate and cause the progressive, deadly neurodegeneration of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Huntington's_disease\">Huntington's disease (HD)<\/a>. ... It's a lead we can vigorously pursue, not just for Huntington's disease, but also for similar neurodegenerative conditions like <a href=\"http:\/\/en.wikipedia.org\/wiki\/Parkinson's_disease\">Parkinson's disease<\/a> and maybe even <a href=\"http:\/\/en.wikipedia.org\/wiki\/Alzheimer's_disease\">Alzheimer's disease<\/a>. ... In HD, an inherited mutation in the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Huntingtin\">huntingtin (htt) gene<\/a> results in misfolded htt proteins accumulating in certain <a href=\"http:\/\/en.wikipedia.org\/wiki\/Central_nervous_system\">central nervous system<\/a> cells. ... [Researchers] focused on a protein called <a href=\"http:\/\/en.wikipedia.org\/wiki\/PPARGC1A\">PGC-1alpha<\/a>, which helps regulate the creation and operation of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mitochondria\">mitochondria<\/a>, the tiny <a href=\"http:\/\/en.wikipedia.org\/wiki\/Organelle\">organelles<\/a> that generate the fuel required for every cell to function. ... It's all about energy. <a href=\"http:\/\/en.wikipedia.org\/wiki\/Neuron\">Neurons<\/a> have a constant, high demand for it. They're always on the edge for maintaining adequate levels of energy production. PGC-1alpha regulates the function of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Transcription_factor\">transcription factors<\/a> that promote the creation of mitochondria and allow them to run at full capacity. ... the mutant form of the htt gene interfered with normal levels and functioning of PGC-1alpha, [and] elevated levels of PGC-1alpha in a mouse model of HD virtually eliminated the problematic misfolded proteins. ... PGC-1alpha influenced expression of another protein vital to <a href=\"http:\/\/en.wikipedia.org\/wiki\/Autophagy\">autophagy<\/a> - the process in which healthy cells degrade and recycle old, unneeded or dangerous parts and products, including oxidative, damaging molecules generated by metabolism. For neurons, which must last a lifetime, the self-renewal is essential to survival. ... Mitochondria get beat up and need to be recycled. PGC-1alpha drives this pathway through another protein called transcription factor <a href=\"http:\/\/en.wikipedia.org\/wiki\/TFEB\">EB or TFEB<\/a>. ... If you can induce the bioenergetics and protein quality control pathways of nervous system cells to function properly, by activating the PGC-1alpha pathway and promoting greater TFEB function, you stand a good chance of maintaining neural function for an extended period of time.\"<\/p>\n<p><span>Link: <a href=\"http:\/\/www.sciencedaily.com\/releases\/2012\/07\/120711141853.htm\">http:\/\/www.sciencedaily.com\/releases\/2012\/07\/120711141853.htm<\/a><\/span><\/p>\n<p>Source:<br \/><a href=\"http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm\">http:\/\/www.longevitymeme.org\/newsletter\/latest_rss_feed.cfm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Via ScienceDaily: researchers \"have identified two key regulatory proteins critical to clearing away misfolded proteins that accumulate and cause the progressive, deadly neurodegeneration of Huntington's disease (HD). ... It's a lead we can vigorously pursue, not just for Huntington's disease, &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/pgc-1alpha-versus-huntingtons-disease-2.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-128964","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/128964"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=128964"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/128964\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=128964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=128964"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=128964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}