{"id":128366,"date":"2010-06-30T08:18:56","date_gmt":"2010-06-30T08:18:56","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/inflammation-genetics-and-longevity\/"},"modified":"2024-08-17T16:58:26","modified_gmt":"2024-08-17T20:58:26","slug":"inflammation-genetics-and-longevity","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/inflammation-genetics-and-longevity.php","title":{"rendered":"Inflammation, Genetics, and Longevity"},"content":{"rendered":"<p>A review paper from Italian researchers who have been working on understanding <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/12\/a-novel-view-of-inflammaging.php\">inflammaging<\/a> for a number of years: \"Ageing is an inexorable intrinsic process that affects all cells, tissues, organs and individuals. Due to a diminished homeostasis and increased organism frailty, ageing causes a reduction of the response to environmental stimuli and, in general, is associated to an increased predisposition to illness and death. Actually, it is characterized by a state of reduced ability to maintain health and general homeodynamics of the organism. A large part of the ageing phenotype is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status of ageing, 'inflamm-ageing'. It is strictly <a href=\"http:\/\/www.fightaging.org\/archives\/2008\/02\/inflammation-and-the-damage-of-aging.php\">linked to immunosenescence<\/a>, and on the whole they are the major contributory factors to the increased frequency of <a href=\"http:\/\/en.wikipedia.org\/wiki\/Morbidity\">morbidity<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Mortality_rate\">mortality<\/a> among elderly. Inflamm-ageing is compatible with longevity; even if <a href=\"http:\/\/en.wikipedia.org\/wiki\/Centenarian\">centenarians<\/a> have an increased level of inflammatory mediators in comparison to old subjects and they are very frail, they also have high level of anti-inflammatory <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cytokine\">cytokines<\/a> together with protective <a href=\"http:\/\/en.wikipedia.org\/wiki\/Genotype\">genotypes<\/a>. Actually, data on case control studies performed in Italian centenarians suggest that a pro-inflammatory genotype is unfavourable to reach extreme longevity in good health and likely favours the onset of age-related diseases such as <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cardiovascular_disease\">cardiovascular diseases<\/a> and <a href=\"http:\/\/en.wikipedia.org\/wiki\/Alzheimer's_disease\">Alzheimer's disease<\/a>.\"<\/p>\n<p>View the Article Under Discussion: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20549353\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20549353<\/a><br \/>\n<br \/>Read More Longevity Meme Commentary: <a href=\"http:\/\/www.longevitymeme.org\/news\" \/>http:\/\/www.longevitymeme.org\/news\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A review paper from Italian researchers who have been working on understanding inflammaging for a number of years: \"Ageing is an inexorable intrinsic process that affects all cells, tissues, organs and individuals. Due to a diminished homeostasis and increased organism &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/longevity-medicine\/inflammation-genetics-and-longevity.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246678],"tags":[],"class_list":["post-128366","post","type-post","status-publish","format-standard","hentry","category-longevity-medicine"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/128366"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=128366"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/128366\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=128366"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=128366"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=128366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}