{"id":1067894,"date":"2020-12-15T21:57:43","date_gmt":"2020-12-16T02:57:43","guid":{"rendered":"https:\/\/www.immortalitymedicine.tv\/sio-gene-therapies-announces-positive-six-month-follow-up-data-from-low-dose-cohort-of-phase-1-2-trial-of-axo-aav-gm1-for-gm1-gangliosidosis\/"},"modified":"2024-08-18T11:40:38","modified_gmt":"2024-08-18T15:40:38","slug":"sio-gene-therapies-announces-positive-six-month-follow-up-data-from-low-dose-cohort-of-phase-1-2-trial-of-axo-aav-gm1-for-gm1-gangliosidosis","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/global-news-feed\/sio-gene-therapies-announces-positive-six-month-follow-up-data-from-low-dose-cohort-of-phase-1-2-trial-of-axo-aav-gm1-for-gm1-gangliosidosis.php","title":{"rendered":"Sio Gene Therapies Announces Positive Six-Month Follow-Up Data from Low-Dose Cohort of Phase 1\/2 Trial of  AXO-AAV-GM1 for GM1 Gangliosidosis"},"content":{"rendered":"<p><![CDATA[-\u00a0 Generally well-tolerated with a favorable safety profile in five patients-\u00a0 Serum beta-galactosidase enzyme activity increased in all patients at all timepoints between Day 7 and Month 6, representing an approximate doubling in enzyme activity after gene transfer-\u00a0 At Month 6, enzyme activity restored to 23-57% (mean: 38%) of normal reference levels-\u00a0 All five children demonstrated signs of clinical disease stability as assessed by Vineland-3 Growth Scale Value, Upright and Floor Mobility, and Clinical Global Impression (CGI) scales-\u00a0 High-dose cohort initiated in November 2020; two patients now dosed without complications]]><\/p>\n<p>Read more:<br \/>\n<a target=\"_blank\" rel=\"nofollow noopener noreferrer\" href=\"http:\/\/www.globenewswire.com\/news-release\/2020\/12\/15\/2145743\/0\/en\/Sio-Gene-Therapies-Announces-Positive-Six-Month-Follow-Up-Data-from-Low-Dose-Cohort-of-Phase-1-2-Trial-of-AXO-AAV-GM1-for-GM1-Gangliosidosis.html?f=22&amp;fvtc=5&amp;fvtv=46634288\" title=\"Sio Gene Therapies Announces Positive Six-Month Follow-Up Data from Low-Dose Cohort of Phase 1\/2 Trial of  AXO-AAV-GM1 for GM1 Gangliosidosis\">Sio Gene Therapies Announces Positive Six-Month Follow-Up Data from Low-Dose Cohort of Phase 1\/2 Trial of  AXO-AAV-GM1 for GM1 Gangliosidosis<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Read more: Sio Gene Therapies Announces Positive Six-Month Follow-Up Data from Low-Dose Cohort of Phase 1\/2 Trial of AXO-AAV-GM1 for GM1 Gangliosidosis <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/global-news-feed\/sio-gene-therapies-announces-positive-six-month-follow-up-data-from-low-dose-cohort-of-phase-1-2-trial-of-axo-aav-gm1-for-gm1-gangliosidosis.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246886],"tags":[],"class_list":["post-1067894","post","type-post","status-publish","format-standard","hentry","category-global-news-feed"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1067894"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1067894"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1067894\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1067894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1067894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1067894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}