{"id":1063172,"date":"2012-07-22T15:47:57","date_gmt":"2012-07-22T15:47:57","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/uc-davis-researchers-score-big-in-113-million-stem-cell-award-round\/"},"modified":"2024-08-17T20:27:34","modified_gmt":"2024-08-18T00:27:34","slug":"uc-davis-researchers-score-big-in-113-million-stem-cell-award-round-2","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/stem-cell-therapy\/uc-davis-researchers-score-big-in-113-million-stem-cell-award-round-2.php","title":{"rendered":"UC Davis Researchers Score Big in $113 Million Stem Cell Award Round"},"content":{"rendered":"<p><a href=\"http:\/\/feedads.g.doubleclick.net\/~a\/LW0JvWXe2lcxcOSu1Nty9uyMnsY\/0\/da\"><img decoding=\"async\" src=\"http:\/\/www.longevitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/76664_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><br><a href=\"http:\/\/feedads.g.doubleclick.net\/~a\/LW0JvWXe2lcxcOSu1Nty9uyMnsY\/1\/da\"><img decoding=\"async\" src=\"http:\/\/www.longevitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/8fbf0_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><\/p><p><span>Scientists at the <\/span><b>University of<br>California at Davis<\/b><span> are set to win nearly half of $113 million<br>expected to be awarded next week by the California stem cell agency<br>as it pushes aggressively to turn research into marketplace cures.<\/span><\/p><div><\/div><div>Directors of the $3 billion agency are<br>virtually certain to approve awards to three researchers at UC Davis,<br>which operates its medical school and other research facilities in<br>nearby Sacramento. The other three expected winners are from <b>UCLA,<br>Stanford <\/b>and <b>StemCells, Inc<\/b>., of Newark, Ca., a publicly traded firm.<\/div><div><\/div><div>The $113 million round is <a href=\"http:\/\/cirm.ca.gov\/our-funding\/where-our-funding-goes\/funding-rounds\/summary-cirm-rounds-funding\">the second largest research round<\/a> in <b>CIRM<\/b>'s history, surpassed only by an<br>another, earlier $211 million &ldquo;disease team&rdquo; round.  The latest<br>effort is aimed at <a href=\"http:\/\/cirm.ca.gov\/files\/grants\/pdf\/Supplement%20RFA10-05.pdf\">bringing proposed clinical trials to the FDA for approval or possibly starting trials within four years.<\/a> That deadline<br>is close to the time when CIRM is scheduled to run out of cash unless<br>new funding sources are developed.<\/div><div><\/div><div>CIRM is currently exploring seeking<br>private financing. It could also ask voters to approve another state<br>bond issue. (Bonds currently provide the only real source of cash for<br>CIRM.) &nbsp;In either case, the agency needs strong, positive results from<br>its grantees to support a bid for continued funding.<\/div><div><\/div><div>The CIRM board is scheduled to approve<br>the latest awards one week from tomorrow at <a href=\"http:\/\/cirm.ca.gov\/Agenda_2012-07-26\/icocgoverning-board\">a public meeting in Burlingame<\/a> in the San Francisco area.  The agency's policy is to<br>withhold the identities of applicants and winners until after formal<br>board action. The <b>California Stem Cell Report<\/b>, however, has pieced<br>together their identities from public records.<\/div><div><\/div><div>Here are the winners and links to the<br>grant review summaries, listed in order of the CIRM scientific<br>scores:<\/div><div><\/div><ul><li><span><b>Vicki Wheelock<\/b>, UC Davis, $19 million,<br>for development of a genetically modified cell therapy for<br>Huntington's disease, an inherited neurodegenerative disorder.<br><a href=\"http:\/\/cirm.ca.gov\/ReviewSummary_DR2A-05415\">Scientific score 87<\/a>.<\/span><\/li><li><span><b>Antoni Ribas<\/b>, UCLA, $20 million, for<br>genetic reprogramming of cells to fight cancer. <a href=\"http:\/\/cirm.ca.gov\/ReviewSummary_DR2A-05309\">Scientific score 84.<\/a><\/span><\/li><li><span><b>Nancy Lane<\/b>, UC Davis, $20 million, for<br>development of a small molecule to promote bone growth for the<br>treatment of osteoporosis.  <a href=\"http:\/\/cirm.ca.gov\/ReviewSummary_DR2A-05302\">Scientific score 80<\/a>.<\/span><\/li><li><span><b>John Laird<\/b>, UC Davis, $14.2 million,<br>for development of mesenchymal stem cells genetically modified  for<br>treatment of critical limb ischemia, which restricts blood flow in<br>the lower leg and can lead to amputation. <a href=\"http:\/\/cirm.ca.gov\/ReviewSummary_DR2A-05423\">Scientific score 79<\/a>.<\/span><\/li><li><span>StemCells, Inc., (principal<br>investigator not yet known), $20 million,  for development of human<br>neural stem cells to treat chronic cervical spinal cord injury. The<br>company, founded by Stanford scientist <b>Irv Weissman<\/b>, who serves on<br>its board, <a href=\"http:\/\/californiastemcellreport.blogspot.com\/2012\/05\/stemcells-inc-hoping-for-as-much-as-40.html\">said earlier this year<\/a> that it had filed two applications<br>in this round, one of which dealt with cervical cord spinal injury.<br>No other applicants filed a proposal for such research.  <a href=\"http:\/\/cirm.ca.gov\/ReviewSummary_DR2A-05736\">Scientific score 79<\/a>.<\/span><\/li><li><span><b>Robert Robbins<\/b>, Stanford, $20 million,<br>development of a human embryonic stem cell treatment for end-stage<br>heart failure. <\/span><a href=\"http:\/\/cirm.ca.gov\/ReviewSummary_DR2A-05394\">Scientific score 68.<\/a><\/li><\/ul><p><span>In the case of businesses, the awards<br>come in the form of loans. Grants go to nonprofits. One of the<br>reasons behind the varying mechanisms is the difference in CIRM's<br>intellectual property rules for businesses and nonprofits.<\/span><\/p><div><\/div><div>CIRM's <b>Grant Working Group<\/b> earlier this<br>year approved the applications during closed door sessions. The full<br>CIRM board has ultimate authority on the applications, but it has<br>almost never rejected a positive action by the grant reviewers.<\/div><div><\/div><div>The board originally <a href=\"http:\/\/cirm.ca.gov\/content\/stem-cell-agency-commits-243-million-expands-team-approach-developing-new-therapies\">allotted $243 million<\/a> for this round. Directors could reach into the 15<br>applications rejected by reviewers and approve any of them, which the<br>board has done in other rounds.  In this round, three rejected<br>applications scored within seven points of the lowest rated<br>application approved by reviewers, which could lead some directors<br>to argue that the scores are not significantly different.  One of the<br>three came from <b>Alexandra Capela<\/b>  of StemCells, Inc., and was <a href=\"http:\/\/cirm.ca.gov\/ReviewSummary_DR2A-05416\">scored at 61<\/a>. The other two and their scores are <b>Clive Svendsen<\/b> of<br><b>Cedars-Sinai<\/b>, <a href=\"http:\/\/cirm.ca.gov\/ReviewSummary_DR2A-05320\">score 64<\/a>, for ALS research, and  <b>Roberta Brinton<\/b> of<br><b>USC<\/b>, <a href=\"http:\/\/cirm.ca.gov\/ReviewSummary_DR2A-05410\">score 63<\/a>, for an Alzheimer's project.<\/div><div><\/div><div>Rejected applicants also can appeal<br>reviewer decisions to the full CIRM board in writing and in public<br>appearances before directors.<\/div><div><\/div><div>Twenty-three researchers were eligible<br>to apply for funding, CIRM told the California Stem Cell Report.<br>Applicants qualified by either <a href=\"http:\/\/cirm.ca.gov\/PressRelease_2011-08-25\">winning a related planning grant<\/a> from<br>CIRM last year or by being granted an exception to that requirement<br>by CIRM staff. Of the 22 researchers who ultimately applied(one<br>nonprofit dropped out), six came from biotech businesses. Three of<br>those qualified through exceptions. Three other businesses won<br>planning grants last year out of the eight businesses that applied.<\/div><div><\/div><div>CIRM has come under fire for its<br>negligible funding of stem cell firms and is moving to embrace<br>industry more warmly.<\/div><div><\/div><div>Only one of the grants approved by<br>reviewers involves research with human embryonic stem cells, which<br>was the critical key to creation of the California stem cell agency.<br>California voters established the agency in 2004 on the basis that it<br>was needed because the <b>Bush Administration<\/b> had restricted federal<br>funding of human embryonic stem cell research. &nbsp;<\/div><div><img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"http:\/\/www.longevitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/8fbf0_10000891-5830653151613479817?l=californiastemcellreport.blogspot.com\" alt=\"\" style=\"padding-left:10px; padding-right: 10px;\"><\/div><p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.longevitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/8fbf0_-ZXHqMF70Eg\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\">Source:<br><a href=\"http:\/\/californiastemcellreport.blogspot.com\/feeds\/posts\/default?alt=rss\">http:\/\/californiastemcellreport.blogspot.com\/feeds\/posts\/default?alt=rss<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Scientists at the University ofCalifornia at Davis are set to win nearly half of $113 millionexpected to be awarded next week by the California stem cell agencyas it pushes aggressively to turn research into marketplace cures.Directors of the $3 billion &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/stem-cell-therapy\/uc-davis-researchers-score-big-in-113-million-stem-cell-award-round-2.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[25,1246878],"tags":[],"class_list":["post-1063172","post","type-post","status-publish","format-standard","hentry","category-stem-cell-therapy","category-stem-cells"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1063172"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1063172"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1063172\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1063172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1063172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1063172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}