Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma.
\n Int J Oncol. 2013 Mar;42(3):1052-60
\n Authors: Zhang M, Wang J, Li C, Hu N, Wang K, Ji H, He D, Quan C, Li X, Jin N, Li Y
\n Abstract
\n Apoptin is a chicken anemia virus-derived, p53-independent, bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis in various human tumor cells, but not in normal cells. To explore the use of apoptin in tumor gene therapy, we assessed a recombinant adenovirus expressing the apoptin protein (Ad-hTERTp-E1a-Apoptin) in order to determine its lethal and growth-inhibitory effects on PC-3 and RM-1 cells in\u00a0vitro and its antitumor effect on solid tumors in\u00a0vivo....<\/p>\n
MedWorm Sponsor Message:<\/i><\/b> Find the best Christmas presents and January Sales<\/a> in the UK with this simple shopping directory.<\/p>\n<\/div>\n Source: Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma. Int J Oncol. 2013 Mar;42(3):1052-60 Authors: Zhang M, Wang J, Li C, Hu N, Wang K, Ji H, He D, Quan C, Li X, Jin N, … Continue reading
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