Authors: Turrell SJ, Macnab SA, Rose A, Melcher AA, Whitehouse A
\n Abstract
\n Herpesvirus saimiri (HVS) is capable of infecting a range of human carcinoma cell types with high efficiency and the viral genome persists as high copy number, circular, non-integrated episomes which segregate to progeny upon cell division. This allows HVS-based vectors to stably transduce a dividing cell population and provide sustained transgene expression for an extended period of time both in vitro and in\u00a0vivo. Moreover, the insertion of a bacterial artificial chromosome cassette into the HVS genome simplifies the incorporation of large amounts of heterologous DNA for gene delivery. Herein we have produced a recombinant HVS-based vector containing full-length human TRAIL under the control of the ?-survi...<\/p>\n
MedWorm Sponsor Message:<\/i><\/b> Please support the Doctors In Chains<\/a> campaign for the medics<\/a> tortured and sentenced for up to 15 years in Bahrain<\/a>. #FreeDoctors<\/a><\/p>\n<\/div>\n Source: Authors: Turrell SJ, Macnab SA, Rose A, Melcher AA, Whitehouse A Abstract Herpesvirus saimiri (HVS) is capable of infecting a range of human carcinoma cell types with high efficiency and the viral genome persists as high copy number, circular, non-integrated … Continue reading
http:\/\/www.medworm.com\/rss\/medicalfeeds\/therapies\/Gene-Therapy.xml<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"