{"id":1058642,"date":"2013-02-06T01:42:52","date_gmt":"2013-02-06T01:42:52","guid":{"rendered":"http:\/\/www.longevitymedicine.tv\/self-regulation-of-normal-lrrk2-by-dfg-flip-video\/"},"modified":"2024-08-17T19:42:30","modified_gmt":"2024-08-17T23:42:30","slug":"self-regulation-of-normal-lrrk2-by-dfg-flip-video","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/parkinsons-disease\/self-regulation-of-normal-lrrk2-by-dfg-flip-video.php","title":{"rendered":"Self regulation of normal LRRK2 by DFG-flip &#8211; Video"},"content":{"rendered":"<p><br \/>Self regulation of normal LRRK2 by DFG-flip<br \/><span>This video demonstrates molecular dynamics simulation of the Parkinson #39;s disease linked kinase called LRRK2. A typical kinase undergoes a duty cycle switching between \"on\" (DFG-in) and \"off\" (DFG-out) states regulating its own activity. The G2019S mutant however does not and stays in a perpetual \"on\" state that eventually eventually leads to Parkinson #39;s disease. See the video on the G2019S to see the differences between wild type and mutant.<\/span><span><\/p>\n<p>By: <\/span>Soumya Ray<span style=\"color: #666666; font-size: 11px;\"<br \/><!-- Auto Generated --><\/p>\n<p>See the original post here:<br \/>\n<a target=\"_blank\" href=\"http:\/\/www.youtube.com\/watch?v=Nl2D5HUUsHc\" title=\"Self regulation of normal LRRK2 by DFG-flip - Video\" rel=\"noopener\">Self regulation of normal LRRK2 by DFG-flip - Video<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p> Self regulation of normal LRRK2 by DFG-flip This video demonstrates molecular dynamics simulation of the Parkinson&#39;s disease linked kinase called LRRK2. A typical kinase undergoes a duty cycle switching between \"on\" (DFG-in) and \"off\" (DFG-out) states regulating its own activity. The G2019S mutant however does not and stays in a perpetual \"on\" state that eventually eventually leads to Parkinson&#39;s disease. See the video on the G2019S to see the differences between wild type and mutant. By: Soumya Ray <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/parkinsons-disease\/self-regulation-of-normal-lrrk2-by-dfg-flip-video.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":64,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246867],"tags":[],"class_list":["post-1058642","post","type-post","status-publish","format-standard","hentry","category-parkinsons-disease"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1058642"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/64"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1058642"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1058642\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1058642"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1058642"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1058642"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}