{"id":1053518,"date":"2012-10-21T07:45:38","date_gmt":"2012-10-21T07:45:38","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/neurology\/gout-patricks-story-nhs-video.php"},"modified":"2024-08-17T18:52:09","modified_gmt":"2024-08-17T22:52:09","slug":"gout-patricks-story-nhs-video","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/gout-patricks-story-nhs-video.php","title":{"rendered":"Gout – Patrick’s story – NHS video"},"content":{"rendered":"

From NHS Choices<\/a> YouTube channel: Patrick, 54, was diagnosed with gout (a form of arthritis) 22 years ago. He describes the symptoms, treatment options and how he learned to live with the condition:<\/p>

Here is a list of some of the new drugs for an old disease (gout):<\/p>

Febuxostat<\/b> is a non-purine-analogue inhibitor of xanthine oxidase that opened a new era in the treatment of gout. <\/p>

Modified uricases<\/b> <\/p>

The use of modified uricases to rapidly reduce serum urate concentrations in patients with otherwise untreatable gout is progressing. Pegloticase<\/b>, a pegylated uricase, is in development. <\/p>

JAMA update, 08\/2011: New Treatment Offers Hope for Patients With Severe Gout: pegloticase (Krystexxa) costs $2,500 per dose (http:\/\/goo.gl\/gz9sO<\/a>). <\/p>

Drugs in development<\/b><\/p>

Transport of uric acid in the renal proximal tubule and the inflammatory response to monosodium urate crystals (shown above) are targets for potential new treatments. <\/p>

Several pipeline drugs for gout related to the targets above include: <\/p>

- selective uricosuric drug RDEA594<\/p>

- various interleukin-1 inhibitors. Canakinumab (trade name Ilaris) is a human monoclonal antibody targeted at interleukin-1 beta. It was rejected by the FDA panel in June 2011<\/a>. <\/p>

References: <\/p>

Gout therapeutics: new drugs for an old disease<\/a>. The Lancet, Volume 377, Issue 9760, Pages 165 - 177, 8 January 2011.
Diuretics, beta-blockers, ACEi, non-losartan ARBs associated with increased risk of gout vs. CCB lower risk. BMJ, 2012<\/a>.
With FDA Approval, a Gout Drug Now Costs $5 Instead of Pennies<\/a> - WSJ, 2011.
FDA Panel Rejects Gout Drug Canakinumab on Safety Concerns http:\/\/goo.gl\/lO9uy<\/a>
The strange story that links gout with the birth of the cocktail drinks. Lancet, 2012<\/a>.<\/p>

Comments from Twitter:<\/p>

francis berenbaum @Larhumato: Gout explained by a patient. Very informative for medical students.<\/p>

Posted at Clinical Cases and Images<\/a>. Stay updated and subscribe<\/a>, follow us on Twitter<\/a> and connect on Facebook<\/a>.\"\"<\/p><\/div>

<\/a>
<\/a><\/p>

Source:
http:\/\/feedproxy.google.com\/~r\/CasesBlog\/~3\/uP_EGE55sT0\/gout-patricks-story-nhs-video.html<\/a><\/p>","protected":false},"excerpt":{"rendered":"

From NHS Choices YouTube channel: Patrick, 54, was diagnosed with gout (a form of arthritis) 22 years ago. He describes the symptoms, treatment options and how he learned to live with the condition:Here is a list of some of the … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246864],"tags":[],"class_list":["post-1053518","post","type-post","status-publish","format-standard","hentry","category-neurology"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053518"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1053518"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053518\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1053518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1053518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1053518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}