Editor's Choice Main Category: Neurology \/ Neuroscience Article Date: 08 Oct 2012 - 0:00 PDT <\/p>\n
Current ratings for: New Agent May Protect Against Brain Damage After Stroke <\/p>\n
At the beginning of their randomized, double-blind trial, the experts had set out to determine whether NA-1 was safe. They then focused their attention on injections of NA-1, and how these injections affected the number and volume of brain legions in stroke patients after surgery. <\/p>\n
During the study, the researchers administered 185 patients who had just undergone surgery with either an intravenous infusion of NA-1 or a saline control - 92 of them received the NA-1 drug, while 93 participants were given the placebo. Throughout the following three days, the team performed MRIs on the patients to examine the degree of stroke legions present. To determine the results, the participants were followed-up 30 days later. <\/p>\n
They wrote that NA-1 is effective and harmless for humans to use, in spite of two unfavorable occurrences where some of the participants were found to have transient low blood pressure caused by the new medication. <\/p>\n
The authors also discovered that NA-1 was capable of lowering brain tissue impairment in the study participants. The patients who received the medication were found to have considerably fewer lesions than those who had been given the saline control. However, lesion volume was similar in the two groups. <\/p>\n
Professor Michael Hill, lead author of the study, explained: <\/p>\n
Our research, which builds on existing animal studies, suggests that intravenous infusion of NA-1 reduces tissue damage in patients who suffer a small stroke after an operation to repair a brain aneurysm, and further research is now needed to investigate the efficacy of neuroprotection in larger clinical trials.\" <\/p>\n
Kaste said: <\/p>\n
However, such drugs should first be assessed in large, well designed and well executed randomised placebo-controlled double-blind clinical trials. Only after such trials will we know whether NA-1 - or one of the other drugs which have shown comparable effects - is the long-awaited holy grail for the treatment of patients with ischaemic stroke. The door is now reopening for new neuroprotection trials in stroke.\" <\/p>\n<\/p>\n
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