{"id":1053368,"date":"2012-04-29T15:47:44","date_gmt":"2012-04-29T15:47:44","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/neurology\/diabetes-drug-injected-once-a-week-gets-f-d-a-approval-bydureon-long-acting-exenatide.php"},"modified":"2024-08-17T18:50:46","modified_gmt":"2024-08-17T22:50:46","slug":"diabetes-drug-injected-once-a-week-gets-f-d-a-approval-bydureon-long-acting-exenatide","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/diabetes-drug-injected-once-a-week-gets-f-d-a-approval-bydureon-long-acting-exenatide.php","title":{"rendered":"Diabetes drug injected once a week gets F.D.A. approval: Bydureon (long-acting exenatide)"},"content":{"rendered":"

From the NYTimes<\/a>:<\/p>

The FDA twice declined to approve long-acting exenatide (Bydureon) in 2010, with its most serious concern being that the drug might contribute to heart rhythm abnormalities. There are safety concerns involving thyroid cancer and pancreatitis.<\/p>

Bydureon is a longer-lasting version of Amylin’s existing drug Byetta, which is injected twice a day. Another company, Alkermes, supplied the technology that slowly releases Bydureon inside the body.<\/p>

Bydureon, Byetta and Victoza are drugs called GLP-1 receptor agonists<\/b>, which mimic the effect of glucagonlike peptide- 1, a hormone that increases insulin production when blood sugar is high.<\/p>

\"\"<\/a>
Figure: Action of DPP-4 inhibitors. Note that DPP-4 normally inactivates GLP-1. DPP-4 inhibitors block DPP-4 which in turn leaves GLP-1 active. Click to enlarge the figure. I made the figure with Gliffy<\/a> in 2006 . The diagram Action of DPP-4 inhibitors<\/span><\/a> is now widely used in many articles on Wikipedia, with my permission.<\/p>

The main ingredient in both Bydureon and Byetta is exenatide, a hormone derived from the saliva of the Gila monster, a poisonous lizard found in the Southwestern United States and Mexico.<\/p>

Wholesale price of Bydureon would be $323 for 4 doses, or about $4,200 a year. That is between the roughly $3,400 for the low dose of Victoza and $5,000 for the high dose.<\/p>

References:<\/p>

Diabetes Drug Injected Weekly Wins F.D.A. Approval<\/a>. NYTimes.<\/p>

Comments from Twitter:<\/p>

Vaughn Eyvazian @Vaughnsays: Increase that pt compliance!<\/p>

Reinaldo B. @basanezrx: but nobody stays in the lowest dose of Victoza in my experience, and that's why most ins companies pay for Byetta instead. A shame \ud83d\ude41<\/p>

Posted at Clinical Cases and Images<\/a>. Stay updated and subscribe<\/a>, follow us on Twitter<\/a> and connect on Facebook<\/a>.\"\"<\/p><\/div>

<\/a>
<\/a><\/p>

Source:
http:\/\/feeds.feedburner.com\/CasesBlog<\/a><\/p>","protected":false},"excerpt":{"rendered":"

From the NYTimes:The FDA twice declined to approve long-acting exenatide (Bydureon) in 2010, with its most serious concern being that the drug might contribute to heart rhythm abnormalities. There are safety concerns involving thyroid cancer and pancreatitis.Bydureon is a longer-lasting … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246864],"tags":[],"class_list":["post-1053368","post","type-post","status-publish","format-standard","hentry","category-neurology"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053368"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1053368"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053368\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1053368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1053368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1053368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}