{"id":1053223,"date":"2011-11-27T16:52:15","date_gmt":"2011-11-27T16:52:15","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/neurology\/linaclotide-for-treatment-of-constipation-minimally-absorbed-peptide-agonist-of-guanylate-cyclase-c-receptor.php"},"modified":"2024-08-17T18:49:13","modified_gmt":"2024-08-17T22:49:13","slug":"linaclotide-for-treatment-of-constipation-minimally-absorbed-peptide-agonist-of-guanylate-cyclase-c-receptor","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/linaclotide-for-treatment-of-constipation-minimally-absorbed-peptide-agonist-of-guanylate-cyclase-c-receptor.php","title":{"rendered":"Linaclotide for treatment of constipation – minimally absorbed peptide agonist of guanylate cyclase C receptor"},"content":{"rendered":"

\"\"<\/a>Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. It consists of 14 amino acids. The sequence<\/a> is:<\/p>

H–Cys1–Cys2–Glu3–Tyr4–Cys5–Cys6–Asn7–Pro8–Ala9–Cys10–Thr11–Gly12–Cys13–Tyr14–OH<\/p>

Two randomized, 12-week trials<\/a> included 1,300 patients with chronic constipation (NEJM, 2011<\/a>). Patients received either placebo or linaclotide once daily for 12 weeks.<\/p>

The incidence of adverse events was similar among all study groups, with the exception of diarrhea, which led to discontinuation of treatment in 4.2% of patients in linaclotide groups.<\/p>

Linaclotide reduced bowel and abdominal symptoms in patients with chronic constipation. Additional studies are needed to evaluate the potential long-term risks of linaclotide in chronic constipation.<\/p>

References:<\/p>

Two Randomized Trials of Linaclotide for Chronic Constipation<\/a>. N Engl J Med 2011; 365:527-536August 11, 2011.<\/p>

Image source: Colon (anatomy)<\/a>, Wikipedia, public domain.<\/p>

Posted at Clinical Cases and Images<\/a>. Stay updated and subscribe<\/a>, follow us on Twitter<\/a> and connect on Facebook<\/a>.\"\"<\/p><\/div>

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Source:
http:\/\/feeds.feedburner.com\/CasesBlog<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. It consists of 14 amino acids. The sequence is:H–Cys1–Cys2–Glu3–Tyr4–Cys5–Cys6–Asn7–Pro8–Ala9–Cys10–Thr11–Gly12–Cys13–Tyr14–OHTwo randomized, 12-week trials included 1,300 patients with chronic constipation (NEJM, 2011). Patients received either placebo or linaclotide once … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246864],"tags":[],"class_list":["post-1053223","post","type-post","status-publish","format-standard","hentry","category-neurology"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053223"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1053223"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053223\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1053223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1053223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1053223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}