{"id":1053079,"date":"2011-04-10T15:49:40","date_gmt":"2011-04-10T15:49:40","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/gout-update-new-drugs-for-an-old-disease\/"},"modified":"2024-08-17T18:47:59","modified_gmt":"2024-08-17T22:47:59","slug":"gout-update-new-drugs-for-an-old-disease","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/gout-update-new-drugs-for-an-old-disease.php","title":{"rendered":"Gout update: New drugs for an old disease"},"content":{"rendered":"<p><a href=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/336dc_220px-Fluorescent_uric_acid.JPG\"><img decoding=\"async\" style=\"padding-left:10px; padding-right: 10px;\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/336dc_220px-Fluorescent_uric_acid.JPG\" border=\"0\" alt=\"\"><\/a>Febuxostat is a non-purine-analogue inhibitor of xanthine oxidase that opened a new era in the treatment of gout.<\/p><div><\/div><div><b>Modified uricases<\/b><p><span><span>The use of modified uricases to<\/span><\/span> rapidly reduce serum urate concentrations in patients with otherwise untreatable gout is progressing. <b>Pegloticase<\/b>, a pegylated uricase, is in development.<\/p><\/div><div><b>Drugs in development<\/b><\/div><div>Transport of uric acid in the renal proximal tubule and the inflammatory response to monosodium urate crystals (shown above) are targets for potential new treatments.<p>Several pipeline drugs for gout related to the targets above include:<\/p><p>- selective uricosuric drug RDEA594<br>- various interleukin-1 inhibitors<\/p><p>References:<br><a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(10)60665-4\/abstract?rss=yes\">Gout therapeutics: new drugs for an old disease<\/a>. The Lancet, Volume 377, Issue 9760, Pages 165 - 177, 8 January 2011.<\/p><\/div><div>Image source: Spiked rods of uric acid (MSU) crystals from a synovial fluid sample photographed under a microscope with polarized light.<a href=\"http:\/\/en.wikipedia.org\/wiki\/File:Fluorescent_uric_acid.JPG\"> Wikipedia<\/a>, public domain.<\/div><div><p>Posted at <a href=\"http:\/\/casesblog.blogspot.com\/\">Clinical Cases and Images<\/a>. Stay updated and <a href=\"http:\/\/feeds.feedburner.com\/CasesBlog\">subscribe<\/a>, follow us on <a href=\"http:\/\/twitter.com\/DrVes\">Twitter<\/a> and connect on <a href=\"http:\/\/www.facebook.com\/DrVes\">Facebook<\/a>.<img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/336dc_11326364-645618241051883774?l=casesblog.blogspot.com\" alt=\"\" style=\"padding-left:10px; padding-right: 10px;\"><\/p><\/div><p><a href=\"http:\/\/feedads.g.doubleclick.net\/~a\/MdexLmCHeJIzkD5ZDsQoTmviR1A\/0\/da\"><img decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/c1430_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><br><a href=\"http:\/\/feedads.g.doubleclick.net\/~a\/MdexLmCHeJIzkD5ZDsQoTmviR1A\/1\/da\"><img decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/c1430_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><\/p><p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/c1430_JhPCWQo9gBE\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Febuxostat is a non-purine-analogue inhibitor of xanthine oxidase that opened a new era in the treatment of gout.Modified uricasesThe use of modified uricases to rapidly reduce serum urate concentrations in patients with otherwise untreatable gout is progressing. Pegloticase, a pegylated &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/gout-update-new-drugs-for-an-old-disease.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246864],"tags":[],"class_list":["post-1053079","post","type-post","status-publish","format-standard","hentry","category-neurology"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053079"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1053079"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053079\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1053079"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1053079"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1053079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}