{"id":1053073,"date":"2011-03-18T13:24:00","date_gmt":"2011-03-18T13:24:00","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/what-drug-to-add-to-maximal-metformin-therapy-for-diabetes\/"},"modified":"2024-08-17T18:47:55","modified_gmt":"2024-08-17T22:47:55","slug":"what-drug-to-add-to-maximal-metformin-therapy-for-diabetes","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/what-drug-to-add-to-maximal-metformin-therapy-for-diabetes.php","title":{"rendered":"What drug to add to maximal metformin therapy for diabetes?"},"content":{"rendered":"<p><a href=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/77dba_200px-Metformin-from-xtal-3D-balls.png\"><img decoding=\"async\" style=\"padding-left:10px; padding-right: 10px;\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/77dba_200px-Metformin-from-xtal-3D-balls.png\" border=\"0\" alt=\"\"><\/a>Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is unclear.<\/p><p>All noninsulin antidiabetic drugs were associated with similar HbA1c reductions but differed in their associations with weight gain and risk of hypoglycemia.<\/p><p>The different classes of drugs were associated with similar HbA1c reductions (range, 0.64%-0.97%) compared with placebo. <\/p><div><\/div><div>Noninsulin antidiabetic drugs and their effect on body weight:<\/div><div><\/div><div>- thiazolidinediones, sulfonylureas, and glinides were associated with weight gain (range, 1.77-2.08 kg)<\/div><div><\/div><div>- glucagon-like peptide-1 analogs, alpha-glucosidase inhibitors, and dipeptidyl peptidase-4 inhibitors were associated with weight loss or no weight change<\/div><div><\/div><div>Sulfonylureas and glinides were associated with higher rates of hypoglycemia than with placebo.<div>References:<\/div><div><a href=\"http:\/\/jama.ama-assn.org\/cgi\/content\/short\/303\/14\/1410?rss=1\">Effect of Noninsulin Antidiabetic Drugs Added to Metformin Therapy on Glycemic Control, Weight Gain, and Hypoglycemia in Type 2 Diabetes<\/a>. JAMA. 2010;303(14):1410-1418. doi: 10.1001\/jama.2010.405<\/div><\/div><div>Image source: Metformin. <a href=\"http:\/\/en.wikipedia.org\/wiki\/Metformin\">Wikipedia<\/a>, public domain.<\/div><div><p>Posted at <a href=\"http:\/\/casesblog.blogspot.com\/\">Clinical Cases and Images<\/a>. Stay updated and <a href=\"http:\/\/feeds.feedburner.com\/CasesBlog\">subscribe<\/a>, follow us on <a href=\"http:\/\/twitter.com\/DrVes\">Twitter<\/a> and connect on <a href=\"http:\/\/www.facebook.com\/DrVes\">Facebook<\/a>.<img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/7bbe0_11326364-716956784764850344?l=casesblog.blogspot.com\" alt=\"\" style=\"padding-left:10px; padding-right: 10px;\"><\/p><\/div><p><a href=\"http:\/\/feedads.g.doubleclick.net\/~a\/x4LWTG6DY1GwUIwHTnSb5c1bmsY\/0\/da\"><img decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/7bbe0_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><br><a href=\"http:\/\/feedads.g.doubleclick.net\/~a\/x4LWTG6DY1GwUIwHTnSb5c1bmsY\/1\/da\"><img decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/8fc88_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><\/p><p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/8fc88_L3qb3PfMsp8\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is unclear.All noninsulin antidiabetic drugs were associated with similar HbA1c reductions but differed in their associations &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/what-drug-to-add-to-maximal-metformin-therapy-for-diabetes.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246864],"tags":[],"class_list":["post-1053073","post","type-post","status-publish","format-standard","hentry","category-neurology"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053073"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1053073"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053073\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1053073"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1053073"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1053073"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}