{"id":1053047,"date":"2011-02-06T18:16:20","date_gmt":"2011-02-06T18:16:20","guid":{"rendered":"http:\/\/www.immortalitymedicine.tv\/vitamin-d-receptor-activation-with-paricalcitol-decreases-albuminuria-in-type-2-diabetes\/"},"modified":"2024-08-17T18:47:44","modified_gmt":"2024-08-17T22:47:44","slug":"vitamin-d-receptor-activation-with-paricalcitol-decreases-albuminuria-in-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/vitamin-d-receptor-activation-with-paricalcitol-decreases-albuminuria-in-type-2-diabetes.php","title":{"rendered":"Vitamin D receptor activation with paricalcitol decreases albuminuria in type 2 diabetes"},"content":{"rendered":"<p><a href=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/db2f9_303px-Paricalcitol_structure.svg.png\"><img decoding=\"async\" style=\"padding-left:10px; padding-right: 10px;\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/db2f9_303px-Paricalcitol_structure.svg.png\" border=\"0\" alt=\"\"><\/a>Despite treatment with renin&mdash;angiotensin&mdash;aldosterone system (RAAS) inhibitors, patients with diabetes have increased risk of progressive renal failure that correlates with albuminuria.<\/p><p>281 patients with type 2 diabetes and albuminuria who were receiving angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were enrolled in this study.<\/p><p>Patients were assigned to receive 24 weeks' treatment with:<\/p><p>- placebo<br>- 1 ?g\/day paricalcitol<br>- 2 ?g\/day paricalcitol<\/p><div>Paricalcitol (trade name Zemplar, Abbott Laboratories) is an analog of calcitriol, the active form of vitamin D.<\/div><div>The primary endpoint was the percentage change in mean urinary albumin-to-creatinine ratio (UACR).<p>The change in urinary albumin-to-creatinine ratio (UACR) was: ?14% in the 1 ?g paricalcitol group, and ?20% in the 2 ?g paricalcitol group.<\/p><p>The addition of 2 ?g\/day paricalcitol to RAAS inhibition safely lowers albuminuria in patients with diabetic nephropathy, and could be a novel approach to lower renal risk in diabetes.<\/p><p>References:<br><a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(10)61032-X\/abstract?rss=yes\">Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial<\/a>. The Lancet, Volume 376, Issue 9752, Pages 1543 - 1551, 6 November 2010.<\/p><\/div><div>Image source: Paricalcitol, <a href=\"http:\/\/en.wikipedia.org\/wiki\/File:Paricalcitol_structure.svg\">Wikipedia<\/a>, public domain.<\/div><div><p>Posted at <a href=\"http:\/\/casesblog.blogspot.com\/\">Clinical Cases and Images<\/a>. Stay updated and <a href=\"http:\/\/feeds.feedburner.com\/CasesBlog\">subscribe<\/a>, follow us on <a href=\"http:\/\/twitter.com\/DrVes\">Twitter<\/a> and connect on <a href=\"http:\/\/www.facebook.com\/DrVes\">Facebook<\/a>.<img loading=\"lazy\" decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/db2f9_11326364-4648732580670327107?l=casesblog.blogspot.com\" alt=\"\" style=\"padding-left:10px; padding-right: 10px;\"><\/p><\/div><p><a href=\"http:\/\/feedads.g.doubleclick.net\/~a\/XmLoIWqPzeedtLV6sMDvLRx4_Ug\/0\/da\"><img decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/f7026_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><br><a href=\"http:\/\/feedads.g.doubleclick.net\/~a\/XmLoIWqPzeedtLV6sMDvLRx4_Ug\/1\/da\"><img decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/f7026_di\" border=\"0\" style=\"padding-left:10px; padding-right: 10px;\"><\/a><\/p><p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.immortalitymedicine.tv\/wp-content\/plugins\/wp-o-matic\/cache\/f7026_q9TpIdK1KhY\" height=\"1\" width=\"1\" style=\"padding-left:10px; padding-right: 10px;\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Despite treatment with renin&mdash;angiotensin&mdash;aldosterone system (RAAS) inhibitors, patients with diabetes have increased risk of progressive renal failure that correlates with albuminuria.281 patients with type 2 diabetes and albuminuria who were receiving angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were enrolled &hellip; <a href=\"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/neurology\/vitamin-d-receptor-activation-with-paricalcitol-decreases-albuminuria-in-type-2-diabetes.php\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"limit_modified_date":"","last_modified_date":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[1246864],"tags":[],"class_list":["post-1053047","post","type-post","status-publish","format-standard","hentry","category-neurology"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053047"}],"collection":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/comments?post=1053047"}],"version-history":[{"count":0,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/posts\/1053047\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/media?parent=1053047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/categories?post=1053047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euvolution.com\/futurist-transhuman-news-blog\/wp-json\/wp\/v2\/tags?post=1053047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}